L’oxytocine dans l’autisme : repenser le traitement et la recherche à travers une perspective neurodivergente

Titre original en anglais : Oxytocin in autism: Rethinking treatment and research through a neurodivergent perspective

Phan, J. M., Dwyer, P., Elsherif, M. M., Friedel, E., & Kapp, S. K. (2024). Oxytocin in autism: Rethinking treatment and research through a neurodivergent perspective. Psychoneuroendocrinology, 171, 107220. https://doi.org/10.1016/j.psyneuen.2024.107220

Date de publication: 19/10/2024 Ajout dans AutiHub: 05/07/2026 Type: Article Langue de l’article: Anglais

Cette publication est intégrée dans AutiHub via :

Auteurs

Auteur·ices des publications
5
Auteur·ices de la publication identifié·es comme autistes
3 / 5 (60,0 %)

Résumé

Cet article de perspective aborde des défis critiques liés aux interventions fondées sur l’oxytocine pour l’autisme, en s’appuyant sur des perspectives neurodivergentes pour mettre en évidence des enjeux clés de pertinence et d’inclusivité de la recherche. Bien qu’il ait été avancé que l’oxytocine module les comportements sociaux et routiniers chez les personnes autistes, les résultats empiriques concernant son efficacité demeurent incohérents. Nous soutenons que ces cibles comportementales peuvent refléter des biais neurotypiques, négligeant souvent les perspectives des personnes autistes, limitant ainsi l’acceptabilité et l’efficacité des interventions. Les recherches antérieures ont fréquemment exclu des populations autistes marginalisées, notamment les personnes présentant une déficience intellectuelle ou des identités de genre diverses, aggravant les problèmes de généralisabilité. Cet article plaide en faveur d’une réorientation des objectifs de recherche sur l’autisme, proposant un passage de la modification des comportements autistiques fondamentaux vers l’amélioration de la qualité de vie grâce à la recherche participative. En intégrant les perspectives autistes dans la conception des études et la sélection des résultats, les chercheurs s’éloignent des cadres axés sur les déficits et privilégient plutôt des résultats socialement valides, tels que la réduction de l’anxiété et l’amélioration du fonctionnement adaptatif. En outre, cet article de perspective critique le recours aux modèles animaux, qui manquent souvent de validité translationnelle en raison des dimensions sociales et communicationnelles complexes de l’autisme. En conclusion, nous soulignons l’importance de pratiques de recherche sur l’autisme inclusives et reproductibles, qui s’alignent sur les expériences vécues et les priorités des personnes autistes. L’adoption de la recherche participative, parallèlement à des ajustements méthodologiques rigoureux, peut favoriser des avancées qui soutiennent efficacement le bien-être de la communauté autiste.

This perspective piece addresses critical challenges in oxytocin-based interventions for autism, drawing on neurodivergent perspectives to highlight key issues in research relevance and inclusivity. Although oxytocin has been posited to modulate social and routinized behaviors in autistic individuals, empirical findings on its efficacy remain inconsistent. We argue that these behavioral targets may reflect neurotypical biases, often disregarding autistic individuals' perspectives, thereby limiting intervention acceptability and efficacy. Past research has frequently excluded marginalized autistic populations, including individuals with intellectual disabilities or gender-diverse identities, exacerbating generalizability issues. This piece advocates for a reorientation of research objectives in autism, proposing a shift from modifying core autistic behaviors towards enhancing quality of life through participatory research. By integrating autistic perspectives into study design and outcome selection, researchers move away from deficit-oriented frameworks and instead prioritize socially valid outcomes, such as reducing anxiety and improving adaptive functioning. Further, the perspective piece critiques the reliance on animal models, which often lack translational validity due to autism's complex social and communicative dimensions. In closing, we underscore the importance of inclusive, reproducible autism research practices that align with the lived experiences and priorities of autistic individuals. Embracing participatory research, alongside rigorous methodological adjustments, can foster advancements that effectively support the well-being of the autistic community.

Bibliographie citée par cette référence

Les références citées sont importées depuis des sources externes de métadonnées lorsqu’elles sont disponibles. La liste peut être partielle.

Vue d’ensemble de l’inclusion dans la bibliographie

Ces indicateurs décrivent la bibliographie citée importée pour cette publication. Les métriques de références citées utilisent le total des références citées comme dénominateur. Les métriques d’auteurices cité·es indiquent si elles utilisent toutes les occurrences d’auteurices cité·es ou seulement les occurrences rattachées à des auteurices déjà intégré·es à la base de données AutiHub. Ils utilisent les rattachements mis en cache entre les auteurices cité·es et les auteurices intégré·es à la base de données AutiHub. Dernier calcul : 16/08/2026 11:30.

Références citées
119
Nombre total de références citées intégrées pour cette publication.
Références citées avec un·e auteur·ice identifié·e comme autiste
39 / 119 (32,8 %)
Occurrences d’auteur·ices cité·es identifié·es comme autistes
94 / 776 (12,1 %)
Parmi les occurrences rattachées à des auteurices intégré·es à la base de données AutiHub : 94 / 352 (26,7 %). Auteurices cité·es distinct·es identifié·es comme autistes : 50 / 668 (7,5 %).
Occurrences citées rattachées à la base AutiHub
352 / 776 (45,4 %)
Auteurices cité·es distinct·es rattaché·es : 262 / 668 (39,2 %)
Occurrences rattachées, non identifiées comme autistes
258 / 352 (73,3 %)
Parmi les seules occurrences rattachées. Sur l’ensemble des occurrences d’auteurices cité·es : 258 / 776 (33,2 %). Auteurices cité·es distinct·es rattaché·es, non identifié·es comme autistes : 212 / 262 (80,9 %).
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