L’oxytocine dans l’autisme : repenser le traitement et la recherche à travers une perspective neurodivergente
Titre original en anglais : Oxytocin in autism: Rethinking treatment and research through a neurodivergent perspective
Phan, J. M., Dwyer, P., Elsherif, M. M., Friedel, E., & Kapp, S. K. (2024). Oxytocin in autism: Rethinking treatment and research through a neurodivergent perspective. Psychoneuroendocrinology, 171, 107220. https://doi.org/10.1016/j.psyneuen.2024.107220
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Résumé
Cet article de perspective aborde des défis critiques liés aux interventions fondées sur l’oxytocine pour l’autisme, en s’appuyant sur des perspectives neurodivergentes pour mettre en évidence des enjeux clés de pertinence et d’inclusivité de la recherche. Bien qu’il ait été avancé que l’oxytocine module les comportements sociaux et routiniers chez les personnes autistes, les résultats empiriques concernant son efficacité demeurent incohérents. Nous soutenons que ces cibles comportementales peuvent refléter des biais neurotypiques, négligeant souvent les perspectives des personnes autistes, limitant ainsi l’acceptabilité et l’efficacité des interventions. Les recherches antérieures ont fréquemment exclu des populations autistes marginalisées, notamment les personnes présentant une déficience intellectuelle ou des identités de genre diverses, aggravant les problèmes de généralisabilité. Cet article plaide en faveur d’une réorientation des objectifs de recherche sur l’autisme, proposant un passage de la modification des comportements autistiques fondamentaux vers l’amélioration de la qualité de vie grâce à la recherche participative. En intégrant les perspectives autistes dans la conception des études et la sélection des résultats, les chercheurs s’éloignent des cadres axés sur les déficits et privilégient plutôt des résultats socialement valides, tels que la réduction de l’anxiété et l’amélioration du fonctionnement adaptatif. En outre, cet article de perspective critique le recours aux modèles animaux, qui manquent souvent de validité translationnelle en raison des dimensions sociales et communicationnelles complexes de l’autisme. En conclusion, nous soulignons l’importance de pratiques de recherche sur l’autisme inclusives et reproductibles, qui s’alignent sur les expériences vécues et les priorités des personnes autistes. L’adoption de la recherche participative, parallèlement à des ajustements méthodologiques rigoureux, peut favoriser des avancées qui soutiennent efficacement le bien-être de la communauté autiste.
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