Trouble du spectre de l'autisme

Titre original en anglais : Autism spectrum disorder

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Lord, C., Brugha, T., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, E. J., Jones, R. M., Pickles, A., State, M. W., Taylor, J. L., & Veenstra‐VanderWeele, J. (2020). Autism spectrum disorder. Nature Reviews Disease Primers, 6(1), 5-5. https://doi.org/10.1038/s41572-019-0138-4

Date de publication: 16/01/2020 Ajout dans AutiHub: 05/07/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
12
Auteur·ices de la publication identifié·es comme autistes
1 / 12 (8,3 %)
  1. Catherine Lord
  2. Traolach Brugha
  3. Tony Charman
  4. James Cusack *
  1. Guillaume Dumas
  2. Thomas Frazier
  3. Emily J.H. Jones
  4. Rebecca M. Jones
  1. Andrew Pickles
  2. Matthew W. State
  3. Julie Lounds Taylor
  4. Jeremy Veenstra‐VanderWeele

Résumé

Le trouble du spectre de l'autisme est un construit utilisé pour décrire les individus présentant une combinaison spécifique d'altérations de la communication sociale et de comportements répétitifs, d'intérêts très restreints et/ou de comportements sensoriels débutant précocement dans la vie. La prévalence mondiale de l'autisme est légèrement inférieure à 1 %, mais les estimations sont plus élevées dans les pays à revenu élevé. Bien qu'une pathologie cérébrale macroscopique ne soit pas caractéristique de l'autisme, des différences anatomiques et fonctionnelles subtiles ont été observées dans des études post-mortem, de neuroimagerie et électrophysiologiques. Initialement, on espérait qu'une mesure précise des phénotypes comportementaux conduirait à des sous-types génétiques spécifiques, mais les résultats génétiques se sont principalement appliqués à des groupes hétérogènes qui ne sont pas spécifiques à l'autisme. Les interventions psychosociales chez les enfants peuvent améliorer des comportements spécifiques, tels que l'attention conjointe, le langage et l'engagement social, qui peuvent influer sur le développement ultérieur et pourraient réduire la sévérité des symptômes. Cependant, des recherches supplémentaires sont nécessaires pour identifier les besoins à long terme des personnes autistes, ainsi que les traitements et les mécanismes qui les sous-tendent et qui pourraient entraîner une amélioration de l'autonomie et de la qualité de vie au fil du temps. Les familles constituent souvent la principale source de soutien pour les personnes autistes pendant une grande partie de leur vie et doivent être prises en compte, de même que les perspectives des personnes autistes, tant dans la recherche que dans la pratique.

Autism spectrum disorder is a construct used to describe individuals with a specific combination of impairments in social communication and repetitive behaviours, highly restricted interests and/or sensory behaviours beginning early in life. The worldwide prevalence of autism is just under 1%, but estimates are higher in high-income countries. Although gross brain pathology is not characteristic of autism, subtle anatomical and functional differences have been observed in post-mortem, neuroimaging and electrophysiological studies. Initially, it was hoped that accurate measurement of behavioural phenotypes would lead to specific genetic subtypes, but genetic findings have mainly applied to heterogeneous groups that are not specific to autism. Psychosocial interventions in children can improve specific behaviours, such as joint attention, language and social engagement, that may affect further development and could reduce symptom severity. However, further research is necessary to identify the long-term needs of people with autism, and treatments and the mechanisms behind them that could result in improved independence and quality of life over time. Families are often the major source of support for people with autism throughout much of life and need to be considered, along with the perspectives of autistic individuals, in both research and practice.

Bibliographie citée par cette référence

Les références citées sont importées depuis des sources externes de métadonnées lorsqu’elles sont disponibles. La liste peut être partielle.

Vue d’ensemble de l’inclusion dans la bibliographie

Ces indicateurs décrivent la bibliographie citée importée pour cette publication. Les métriques de références citées utilisent le total des références citées comme dénominateur. Les métriques d’auteurices cité·es indiquent si elles utilisent toutes les occurrences d’auteurices cité·es ou seulement les occurrences rattachées à des auteurices déjà intégré·es à la base de données AutiHub. Ils utilisent les rattachements mis en cache entre les auteurices cité·es et les auteurices intégré·es à la base de données AutiHub. Dernier calcul : 16/08/2026 11:30.

Références citées
463
Nombre total de références citées intégrées pour cette publication.
Références citées avec un·e auteur·ice identifié·e comme autiste
3 / 463 (0,6 %)
Occurrences d’auteur·ices cité·es identifié·es comme autistes
5 / 6127 (0,1 %)
Parmi les occurrences rattachées à des auteurices intégré·es à la base de données AutiHub : 5 / 591 (0,8 %). Auteurices cité·es distinct·es identifié·es comme autistes : 5 / 4480 (0,1 %).
Occurrences citées rattachées à la base AutiHub
591 / 6127 (9,6 %)
Auteurices cité·es distinct·es rattaché·es : 184 / 4480 (4,1 %)
Occurrences rattachées, non identifiées comme autistes
586 / 591 (99,2 %)
Parmi les seules occurrences rattachées. Sur l’ensemble des occurrences d’auteurices cité·es : 586 / 6127 (9,6 %). Auteurices cité·es distinct·es rattaché·es, non identifié·es comme autistes : 179 / 184 (97,3 %).
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