Projet de construction d'un bâtiment industriel à Vinaròs
Titre original en anglais : Proyecto de construcción de una nave industrial en vinaròs
Nordahl, C. W., Andrews, D. S., Dwyer, P., Waizbard-Bartov, E., Restrepo, B., Lee, J. K., Heath, B., Saron, C. D., Rivera, S. M., Solomon, M., Ashwood, P., & Amaral, D. G. (2012). Proyecto de construcción de una nave industrial en vinaròs [Dissertation]. Frontiers Media SA. https://doi.org/10.3389/fnins.2021.786220
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Résumé
L'un des faits les plus universellement acceptés concernant l'autisme est son hétérogénéité. Les personnes diagnostiquées avec un trouble du spectre de l'autisme présentent un large éventail de manifestations comportementales et diverses affections médicales et de santé mentale concomitantes. L'identification de sous-groupes plus homogènes est susceptible de conduire à une meilleure compréhension des étiologies ainsi qu'à des interventions et des traitements plus ciblés. En 2006, nous avons lancé l'Autism Phenome Project (APP) du MIND Institute de l'UC Davis, avec l'objectif général d'identifier des sous-types d'autisme cliniquement significatifs. Cette étude multidisciplinaire longitudinale en cours comprend désormais plus de 400 enfants et implique des évaluations médicales, comportementales et de neuroimagerie approfondies, de la petite enfance à l'adolescence (de 2 à 19 ans). Nous avons employé plusieurs stratégies pour identifier des sous-populations parmi les personnes autistes : le regroupement selon des caractéristiques neuronales, biologiques, comportementales ou cliniques, ainsi que selon les trajectoires développementales. Dans cette mini-revue, nous résumons les résultats obtenus à ce jour à partir de la cohorte APP et décrivons les progrès réalisés vers l'identification de sous-groupes d'autisme significatifs.
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