Psychotherapie adaptée au spectre de l’autisme pour adultes (SPECTRAA) : protocole d’étude pour un essai contrôlé randomisé de thérapie cognitivo-comportementale individuelle à court terme pour la symptomatologie centrale de l’autisme et les comorbidités fréquentes

Titre original en anglais : Autism Spectrum Adapted Psychotherapy for Adults (SPECTRAA): Study protocol for a randomised controlled trial of individual, short-term cognitive behavioural therapy for core autism symptomatology and common comorbidities

Sources de métadonnées utilisées pour cette référence

OpenAlex Crossref
En savoir plus sur les sources utilisées

Küpper, C., Elsner, B., Jörke, J., Lipinski, S., & Dziobek, I. (2026). Autism Spectrum Adapted Psychotherapy for Adults (SPECTRAA): Study protocol for a randomised controlled trial of individual, short-term cognitive behavioural therapy for core autism symptomatology and common comorbidities [Preprint]. Springer Science and Business Media LLC. https://doi.org/10.21203/rs.3.rs-8591205/v1

Date de publication: 28/05/2026 Ajout dans AutiHub: 06/07/2026 Type: Prépublication Langue de l’article: Anglais
Source OpenAlex Source éditeur (DOI)

Cette publication est intégrée dans AutiHub via :

Auteurs

Auteur·ices des publications
5
Auteur·ices de la publication identifié·es comme autistes
1 / 5 (20,0 %)
  1. Charlotte Küpper
  2. Björn Elsner
  3. Josephine Jörke
  4. Silke Lipinski *
  5. Isabel Dziobek

Résumé

Résumé Contexte : Le trouble du spectre de l’autisme est une condition neurodéveloppementale permanente, avec un taux de prévalence de 1 à 2 %, caractérisée par des difficultés persistantes dans l’interaction sociale et la communication, ainsi que par des comportements et intérêts restreints et répétitifs. De nombreux adultes autistes sans déficiences intellectuelles ou langagières rencontrent des difficultés dans de multiples domaines de la vie et développent fréquemment des troubles mentaux et somatiques comorbides. Malgré un fort désir de soutien thérapeutique, l’accès à des soins psychologiques ou psychiatriques appropriés est souvent limité. Les interventions fondées sur des données probantes spécifiquement adaptées aux adultes autistes sont rares. Bien que certaines interventions de groupe aient montré des résultats prometteurs, il existe un manque d’approches de thérapie individuelle structurées, manualisées et évaluées empiriquement. Une telle psychothérapie peut offrir des caractéristiques qui correspondent bien aux besoins et préférences de traitement fréquemment rapportés par les adultes autistes, notamment un rythme adapté, la prise en compte des vulnérabilités sensorielles et sociales, une plus grande prévisibilité ainsi que le travail sur des objectifs individuels. À ce jour, l’efficacité d’une thérapie cognitivo-comportementale (TCC) individuelle ciblant les caractéristiques centrales de l’autisme et les comorbidités fréquentes chez les adultes n’a pas été examinée systématiquement. Méthodes : 236 participants adultes atteints d’un trouble du spectre de l’autisme prendront part à un essai contrôlé randomisé pragmatique, monocentrique, à groupes parallèles, qui compare un programme individuel manualisé de thérapie cognitivo-comportementale à court terme adapté au spectre de l’autisme (SPECTRAA) à des « soins standard améliorés », c’est-à-dire un « traitement habituel » amélioré par un processus diagnostique complet spécifique à l’autisme et une séance individuelle de conseil sur les services de soutien spécifiques à l’autisme disponibles en Allemagne. Le critère de jugement principal est la Social Responsiveness Scale, renseignée par des informateurs (par exemple, parents, partenaires ou autres personnes connaissant la communication et l’interaction sociales du participant). L’implication des patients et du public a joué un rôle central tout au long de l’élaboration de l’essai et de la prise de décision. Discussion : Cet essai vise à combler plusieurs lacunes dans le domaine des interventions pour l’autisme. Il concerne des adultes sans déficience intellectuelle et constitue à ce jour le premier ECR interventionnel à grande échelle centré sur une psychothérapie individuelle fondée sur la TCC, conçue pour traiter les symptômes centraux de l’autisme et les comorbidités fréquentes chez les adultes autistes. L’approche individualisée peut améliorer l’acceptabilité du traitement et sa pertinence clinique. Enregistrement de l’essai : Registre allemand des essais cliniques, numéro d’identification de l’essai : DRKS00027914, enregistré le 11 avril 2025

Abstract Background: Autism Spectrum Disorder is a lifelong neurodevelopmental condition with a prevalence rate of 1-2%, characterised by persistent impairments in social interaction and communication, as well as restricted and repetitive behaviours and interests. Many autistic adults without intellectual or language impairments experience challenges across multiple domains of life and commonly develop comorbid mental and somatic disorders. Despite a strong desire for therapeutic support, access to appropriate psychological or psychiatric care is often limited. Evidence-based interventions specifically tailored to autistic adults are rare. Although some group-based interventions have shown promising results, there is a lack of structured, manualised, and empirically evaluated individual therapy approaches. Such psychotherapy may offer features that align well with the treatment needs and preferences frequently reported by autistic adults, including tailored pacing, consideration of sensory and social vulnerabilities, greater predictability as well as working on individual goals. To date, the efficacy of individual cognitive-behavioural therapy (CBT) targeting core autism characteristics and common comorbidities in adults has not been systematically examined. Methods: 236 adult participants with an autism spectrum disorder will take part in a single-centre, parallel-group, pragmatic randomised controlled trial that compares an autism spectrum adapted individual manualised short-term cognitive behavioural therapy programme (SPECTRAA) with “enhanced standard care”, i.e. “treatment as usual” enhanced by a comprehensive autism-specific diagnostic process and an individual counselling session on autism-specific support services as available in Germany. The primary outcome is the Social Responsiveness Scale, completed by informants (e.g., parents, partners, or others familiar with the participant’s social communication and interaction). Patient and public involvement played a central role throughout the trial development and decision making. Discussion: This trial aims to address several gaps in the field of autism interventions. It addresses adults without intellectual disability and is the first large-scale interventional RCT to date focussing on individual CBT-based psychotherapy designed to treat core autism symptoms and common comorbidities in autistic adults. The individualised approach may enhance treatment acceptability and clinical relevance. Trial registration: German Clinical Trial Register, Trial Identifying Number: DRKS00027914, Registered on 11 April 2025

Bibliographie citée par cette référence

Les références citées sont importées depuis des sources externes de métadonnées lorsqu’elles sont disponibles. La liste peut être partielle.

Vue d’ensemble de l’inclusion dans la bibliographie

Ces indicateurs décrivent la bibliographie citée importée pour cette publication. Les métriques de références citées utilisent le total des références citées comme dénominateur. Les métriques d’auteurices cité·es indiquent si elles utilisent toutes les occurrences d’auteurices cité·es ou seulement les occurrences rattachées à des auteurices déjà intégré·es à la base de données AutiHub. Ils utilisent les rattachements mis en cache entre les auteurices cité·es et les auteurices intégré·es à la base de données AutiHub. Dernier calcul : 16/08/2026 11:30.

Références citées
97
Nombre total de références citées intégrées pour cette publication.
Références citées avec un·e auteur·ice identifié·e comme autiste
6 / 97 (6,2 %)
Occurrences d’auteur·ices cité·es identifié·es comme autistes
6 / 424 (1,4 %)
Parmi les occurrences rattachées à des auteurices intégré·es à la base de données AutiHub : 6 / 89 (6,7 %). Auteurices cité·es distinct·es identifié·es comme autistes : 3 / 362 (0,8 %).
Occurrences citées rattachées à la base AutiHub
89 / 424 (21,0 %)
Auteurices cité·es distinct·es rattaché·es : 52 / 362 (14,4 %)
Occurrences rattachées, non identifiées comme autistes
83 / 89 (93,3 %)
Parmi les seules occurrences rattachées. Sur l’ensemble des occurrences d’auteurices cité·es : 83 / 424 (19,6 %). Auteurices cité·es distinct·es rattaché·es, non identifié·es comme autistes : 49 / 52 (94,2 %).
  2. González Moreno, Andrés Santiago (2013). Diagnostic and Statistical Manual of Mental Disorders . American Psychiatric Association.
    Type: Livre DOI: 10.1176/appi.books.9780890425596 OpenAlex: https://openalex.org/W4247665917
    Crossref OpenAlex
  3. Brian Reichow , Amanda M Steiner , Fred Volkmar (2012). Social skills groups for people aged 6 to 21 with autism spectrum disorders (ASD) . Cochrane Database of Systematic Reviews, 2013(9), CD008511-CD008511. Wiley.
    Type: Article DOI: 10.1002/14651858.cd008511.pub2 OpenAlex: https://openalex.org/W1491420630
    Crossref OpenAlex
  4. Jinan Zeidan , Éric Fombonne , Julie Scorah , Alaa T. Ibrahim , Maureen S. Durkin , Shekhar Saxena et al. (2022). Global prevalence of autism: A systematic review update . Autism Research, 15(5), 778-790. Wiley.
    Type: Article DOI: 10.1002/aur.2696 OpenAlex: https://openalex.org/W4214849391
    Crossref OpenAlex
  5. P. Retz-Junginger , W. Retz , D. Blocher , H.-G. Weijers , G.-E. Trott , P.H. Wender et al. (2002). Wender Utah Rating Scale (WURS-k) Die deutsche Kurzform zur retrospektiven Erfassung des hyperkinetischen Syndroms bei Erwachsenen . Der Nervenarzt, 73(9), 830-838. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s00115-001-1215-x OpenAlex: https://openalex.org/W1496236868
    Crossref OpenAlex
  6. Michael Ayres , Jeremy R. Parr , Jacqui Rodgers , David Mason , Leah Avery , Darren Flynn (2018). A systematic review of quality of life of adults on the autism spectrum . Autism, 22(7), 774-783. SAGE Publications.
    Type: Article DOI: 10.1177/1362361317714988 OpenAlex: https://openalex.org/W2743496150
    Crossref OpenAlex
  7. M. Rösler , W. Retz , P. Retz-Junginger , J. Thome , T. Supprian , T. Nissen et al. (2004). Instrumente zur Diagnostik der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) im Erwachsenenalter . Der Nervenarzt, 75(9), 888-895. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s00115-003-1622-2 OpenAlex: https://openalex.org/W1550424397
    Crossref OpenAlex
  8. David Mason , Helen McConachie , Deborah Garland , Alex Petrou , Jacqui Rodgers , Jeremy R. Parr (2018). Predictors of quality of life for autistic adults . Autism Research, 11(8), 1138-1147. Wiley.
    Type: Article DOI: 10.1002/aur.1965 OpenAlex: https://openalex.org/W2800039438
    Crossref OpenAlex
  9. C. Kühner , C. Bürger , F. Keller , M. Hautzinger (2007). Reliabilität und Validität des revidierten Beck-Depressionsinventars (BDI-II) . Der Nervenarzt, 78(6), 651-656. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s00115-006-2098-7 OpenAlex: https://openalex.org/W1606961096
    Crossref OpenAlex
  10. Fabian Frank , Martina Jablotschkin , Tobias Arthen , Andreas Riedel , Thomas Fangmeier , Lars P. Hölzel et al. (2018). Education and employment status of adults with autism spectrum disorders in Germany – a cross-sectional-survey . BMC Psychiatry, 18(1), 75. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/s12888-018-1645-7 OpenAlex: https://openalex.org/W2804950989
    Crossref OpenAlex
  11. Martin Schumacher , Gabi Schulgen/Kristiansen (2008). Methodik klinischer Studien . Springer Berlin Heidelberg.
    Type: Livre DOI: 10.1007/978-3-540-85136-3 OpenAlex: https://openalex.org/W1665487994
    Crossref OpenAlex
  12. Javad Alaghband-rad , Arman Hajikarim-Hamedani , Mahtab Motamed (2023). Camouflage and masking behavior in adult autism . Frontiers in Psychiatry, 14, 1108110-1108110. Frontiers Media SA.
    Type: Article DOI: 10.3389/fpsyt.2023.1108110 OpenAlex: https://openalex.org/W4327614205
    Crossref OpenAlex
  13. David Kriz , Rüdiger Nübling , Andrés Steffanowski , Werner W. Wittmann , Jürgen Schmidt (2008). Patientenzufriedenheit in der stationären Rehabilitation: Psychometrische Reanalyse des ZUF-8 auf der Basis multizentrischer Stichproben verschiedener Indikation . Zeitschrift für Medizinische Psychologie, 17(2-3), 67-79. IOS Press.
    Type: Article DOI: 10.3233/zmp-2008-17_2-3_04 OpenAlex: https://openalex.org/W1777503914
    Crossref OpenAlex
  14. Md Mahbub Hossain , Nusrat Khan , Abida Sultana , Ping Ma , E. Lisako J. McKyer , Helal Uddin Ahmed et al. (2020). Prevalence of comorbid psychiatric disorders among people with autism spectrum disorder: An umbrella review of systematic reviews and meta-analyses . Psychiatry Research, 287, 112922. Elsevier BV.
    Type: Article DOI: 10.1016/j.psychres.2020.112922 OpenAlex: https://openalex.org/W2997685177
    Crossref OpenAlex
  15. T. Fangmeier , A. Lichtblau , J. Peters , M. Biscaldi-Schäfer , D. Ebert , L.T. van Elst (2011). Psychotherapie des Asperger-Syndroms im Erwachsenenalter . Der Nervenarzt, 82(5), 628-635. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s00115-010-3121-6 OpenAlex: https://openalex.org/W1927378690
    Crossref OpenAlex
  16. Tatja Hirvikoski , Ellenor Mittendorfer-Rutz , Marcus Boman , Henrik Larsson , Paul Lichtenstein , Sven Bölte (2016). Premature mortality in autism spectrum disorder . British Journal of Psychiatry, 208(3), 232-238. Royal College of Psychiatrists.
    Type: Article DOI: 10.1192/bjp.bp.114.160192 OpenAlex: https://openalex.org/W2168424072
    Crossref OpenAlex
  17. Douglas Bates , Martin Mächler , Ben Bolker , Steve Walker (2015). Fitting Linear Mixed-Effects Models Using lme4 . Journal of Statistical Software, 67(1). Foundation for Open Access Statistic.
    Type: Article DOI: 10.18637/jss.v067.i01 OpenAlex: https://openalex.org/W1951724000
    Crossref OpenAlex
  19. Annelies A. Spek , Nadia C. van Ham , Ivan Nyklíček (2013). Mindfulness-based therapy in adults with an autism spectrum disorder: A randomized controlled trial . Research in Developmental Disabilities, 34(1), 246-253. Elsevier BV.
    Type: Article DOI: 10.1016/j.ridd.2012.08.009 OpenAlex: https://openalex.org/W1964450263
    Crossref OpenAlex
  20. Isabel Dziobek (2021). Psychotherapie - ein Kompetenzorientiertes Lehrbuch . Psychotherapie - ein Kompetenzorientiertes Lehrbuch.
    Type: Autre
    Crossref
  21. Frank W. Bond , Steven C. Hayes , Ruth A. Baer , Kenneth M. Carpenter , Nigel Guenole , Holly K. Orcutt et al. (2011). Preliminary Psychometric Properties of the Acceptance and Action Questionnaire–II: A Revised Measure of Psychological Inflexibility and Experiential Avoidance . Behavior Therapy, 42(4), 676-688. Elsevier BV.
    Type: Article DOI: 10.1016/j.beth.2011.03.007 OpenAlex: https://openalex.org/W1966524739
    Crossref OpenAlex
  22. Ludger Tebartz van Elst , Thomas Fangmeier , Ulrich Max Schaller , Oliver Hennig , Meinhard Kieser , Katja Koelkebeck et al. (2021). FASTER and SCOTT&EVA trainings for adults with high-functioning autism spectrum disorder (ASD): study protocol for a randomized controlled trial . Trials, 22(1), 261. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/s13063-021-05205-9 OpenAlex: https://openalex.org/W3126308466
    Crossref OpenAlex
  23. Sandra L Baker , Nina Heinrichs , Hyo-Jin Kim , Stefan G Hofmann (2002). The Liebowitz social anxiety scale as a self-report instrument: a preliminary psychometric analysis . Behaviour Research and Therapy, 40(6), 701-715. Elsevier BV.
    Type: Article DOI: 10.1016/s0005-7967(01)00060-2 OpenAlex: https://openalex.org/W1974382475
    Crossref OpenAlex
  24. Isabel Dziobek , Sandra Stoll (2019). Hochfunktionaler Autismus bei Erwachsenen . W. Kohlhammer GmbH.
    Type: Livre DOI: 10.17433/978-3-17-032032-1 OpenAlex: https://openalex.org/W2990101879
    Crossref OpenAlex
  25. Gabriel Kaplan , James T. McCracken (2012). Psychopharmacology of Autism Spectrum Disorders . Pediatric Clinics of North America, 59(1), 175-187. Elsevier BV.
    Type: Article DOI: 10.1016/j.pcl.2011.10.005 OpenAlex: https://openalex.org/W2022809536
    Crossref OpenAlex
  27. Glen I. Spielmans , Joseph P. McFall (2006). A Comparative Meta-Analysis of Clinical Global Impressions Change in Antidepressant Trials . Journal of Nervous & Mental Disease, 194(11), 845-852. Ovid Technologies (Wolters Kluwer Health).
    Type: Article DOI: 10.1097/01.nmd.0000244554.91259.27 OpenAlex: https://openalex.org/W2025100359
    Crossref OpenAlex
  28. Samuel Brice , Jacqui Rodgers , Barry Ingham , David Mason , Colin Wilson , Mark Freeston et al. (2021). The importance and availability of adjustments to improve access for autistic adults who need mental and physical healthcare: findings from UK surveys . BMJ Open, 11(3), e043336. BMJ.
    Type: Article DOI: 10.1136/bmjopen-2020-043336 OpenAlex: https://openalex.org/W3138477195
    Crossref OpenAlex
  29. Stefan Leucht , John M. Kane , Werner Kissling , Johannes Hamann , Eva Etschel , Rolf Engel (2005). Clinical implications of Brief Psychiatric Rating Scale scores . British Journal of Psychiatry, 187(4), 366-371. Royal College of Psychiatrists.
    Type: Article DOI: 10.1192/bjp.187.4.366 OpenAlex: https://openalex.org/W2032712358
    Crossref OpenAlex
  31. Ed Diener , Derrick Wirtz , William Tov , Chu Kim-Prieto , Dong-won Choi , Shigehiro Oishi et al. (2010). New Well-being Measures: Short Scales to Assess Flourishing and Positive and Negative Feelings . Social Indicators Research, 97(2), 143-156. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s11205-009-9493-y OpenAlex: https://openalex.org/W2037755177
    Crossref OpenAlex
  32. Tina Schweizer , Dominique Endres , Isabel Dziobek , Ludger Tebartz van Elst (2024). Psychosocial therapeutic approaches for high-functioning autistic adults . Frontiers in Psychiatry, 14, 1265066. Frontiers Media SA.
    Type: Article DOI: 10.3389/fpsyt.2023.1265066 OpenAlex: https://openalex.org/W4390745133
    Crossref OpenAlex
  33. D. M. FRESCO , M. E. COLES , R. G. HEIMBERG , M. R. LIEBOWITZ , S. HAMI , M. B. STEIN et al. (2001). The Liebowitz Social Anxiety Scale: a comparison of the psychometric properties of self-report and clinician-administered formats . Psychological Medicine, 31(6), 1025-1035. Cambridge University Press (CUP).
    Type: Article DOI: 10.1017/s0033291701004056 OpenAlex: https://openalex.org/W2039810696
    Crossref OpenAlex
  34. Robert H. Wichers , Lisa C. van der Wouw , Marlies E. Brouwer , Anja Lok , Claudi L. H. Bockting (2023). Psychotherapy for co-occurring symptoms of depression, anxiety and obsessive-compulsive disorder in children and adults with autism spectrum disorder: a systematic review and meta-analysis . Psychological Medicine, 53(1), 17-33. Cambridge University Press (CUP).
    Type: Article DOI: 10.1017/s0033291722003415 OpenAlex: https://openalex.org/W4309513583
    Crossref OpenAlex
  35. Kenneth F. Schulz , Doug Altman , David Moher , for the CONSORT Group* (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomized Trials . Annals of Internal Medicine, 152(11), 726-732. American College of Physicians.
    Type: Article DOI: 10.7326/0003-4819-152-11-201006010-00232 OpenAlex: https://openalex.org/W2049103906
    Crossref OpenAlex
  37. Bram B. Sizoo , Erik Kuiper (2017). Cognitive behavioural therapy and mindfulness based stress reduction may be equally effective in reducing anxiety and depression in adults with autism spectrum disorders . Research in Developmental Disabilities, 64, 47-55. Elsevier BV.
    Type: Article DOI: 10.1016/j.ridd.2017.03.004 OpenAlex: https://openalex.org/W2601014375
    Crossref OpenAlex
  38. Thomas D. Borkovec , Sidney D. Nau (1972). Credibility of analogue therapy rationales . Journal of Behavior Therapy and Experimental Psychiatry, 3(4), 257-260. Elsevier BV.
    Type: Article DOI: 10.1016/0005-7916(72)90045-6 OpenAlex: https://openalex.org/W2066807621
    Crossref OpenAlex
  39. National Institute for Health , Care Excellence (2021). Autism spectrum disorder in under 19s: recognition, referral and diagnosis .
    Type: Autre
    Crossref
  40. Stefan Leucht , Rolf R Engel (2006). The Relative Sensitivity of the Clinical Global Impressions Scale and the Brief Psychiatric Rating Scale in Antipsychotic Drug Trials . Neuropsychopharmacology, 31(2), 406-412. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/sj.npp.1300873 OpenAlex: https://openalex.org/W2067499064
    Crossref OpenAlex
  41. (s. d.). Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie e. V. (DGKJP). S3-Leitlinie Autismus-Spektrum-Störungen im Kindes-, Jugend- und Erwachsenenalter. Teil 2: Therapie (Version 1. 1). https://register.awmf.org/de/leitlinien/detail/028-047 .
    Type: Autre
    Crossref
  42. Sven Bölte (2012). Brief Report: The Social Responsiveness Scale for Adults (SRS-A): Initial Results in a German Cohort . Journal of Autism and Developmental Disorders, 42(9), 1998-1999. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-011-1424-5 OpenAlex: https://openalex.org/W2069807232
    Crossref OpenAlex
  43. Ebert D (2013). Tebartz van Elst L. Asperger- Autismus und hochfunktionaler Autismus bei Erwachsenen. Das Therapiemanual der Freiburger Autismus-Studiengruppe . Tebartz van Elst L. Asperger- Autismus und hochfunktionaler Autismus bei Erwachsenen. Das Therapiemanual der Freiburger Autismus-Studiengruppe.
    Type: Autre
    Crossref
  44. Tobias Esch , Gerald Jose , Christine Gimpel , Christel von Scheidt , Andreas Michalsen (2013). Die Flourishing Scale (FS) von Diener et al. liegt jetzt in einer autorisierten deutschen Fassung (FS-D) vor: Einsatz bei einer Mind-Body-medizinischen Fragestellung . Complementary Medicine Research, 20(4), 267-275. S. Karger AG.
    Type: Article DOI: 10.1159/000354414 OpenAlex: https://openalex.org/W2081139605
    Crossref OpenAlex
  45. T. I. ZAIDER , R. G. HEIMBERG , D. M. FRESCO , F. R. SCHNEIER , M. R. LIEBOWITZ (2003). Evaluation of the Clinical Global Impression Scale among individuals with social anxiety disorder . Psychological Medicine, 33(4), 611-622. Cambridge University Press (CUP).
    Type: Article DOI: 10.1017/s0033291703007414 OpenAlex: https://openalex.org/W2091673534
    Crossref OpenAlex
  46. TebartzElst L (2019). 12. Wissenschaftliche Tagung Autimsus-Spektrum, 21.–22.2.2019, Tagungsband . 12. Wissenschaftliche Tagung Autimsus-Spektrum, 21.–22.2.2019, Tagungsband.
    Type: Autre
    Crossref
  47. James C. Mundt , Isaac M. Marks , M. Katherine Shear , John M. Greist (2002). The Work and Social Adjustment Scale: a simple measure of impairment in functioning . British Journal of Psychiatry, 180(5), 461-464. Royal College of Psychiatrists.
    Type: Article DOI: 10.1192/bjp.180.5.461 OpenAlex: https://openalex.org/W2096230543
    Crossref OpenAlex
  48. Simon Baron-Cohen , Sally Wheelwright , Richard Skinner , Joanne Martin , Emma Clubley (2001). The Autism-Spectrum Quotient (AQ): Evidence from Asperger Syndrome/High-Functioning Autism, Males and Females, Scientists and Mathematicians . Journal of Autism and Developmental Disorders, 31(1), 5-17. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1023/a:1005653411471 OpenAlex: https://openalex.org/W2100254283
    Crossref OpenAlex
  49. Leonard R. Derogatis , Nick Melisaratos (1983). The Brief Symptom Inventory: an introductory report . Psychological Medicine, 13(3), 595-605. Cambridge University Press (CUP).
    Type: Article DOI: 10.1017/s0033291700048017 OpenAlex: https://openalex.org/W2107959833
    Crossref OpenAlex
  50. Alana J. McVey , Bridget K. Dolan , Kirsten S. Willar , Sheryl Pleiss , Jeffrey S. Karst , Christina L. Casnar et al. (2016). A Replication and Extension of the PEERS® for Young Adults Social Skills Intervention: Examining Effects on Social Skills and Social Anxiety in Young Adults with Autism Spectrum Disorder . Journal of Autism and Developmental Disorders, 46(12), 3739-3754. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-016-2911-5 OpenAlex: https://openalex.org/W2520688902
    Crossref OpenAlex
  51. Eva Hesselmark , Stephanie Plenty , Susanne Bejerot (2014). Group cognitive behavioural therapy and group recreational activity for adults with autism spectrum disorders: A preliminary randomized controlled trial . Autism, 18(6), 672-683. SAGE Publications.
    Type: Article DOI: 10.1177/1362361313493681 OpenAlex: https://openalex.org/W2111548096
    Crossref OpenAlex
  52. Tasha M. Oswald , Breanna Winder-Patel , Steven Ruder , Guibo Xing , Aubyn C. Stahmer , Marjorie Solomon (2018). A Pilot Randomized Controlled Trial of the ACCESS Program: A Group Intervention to Improve Social, Adaptive Functioning, Stress Coping, and Self-Determination Outcomes in Young Adults with Autism Spectrum Disorder . Journal of Autism and Developmental Disorders, 48(5), 1742-1760. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-017-3421-9 OpenAlex: https://openalex.org/W2775578392
    Crossref OpenAlex
  53. Clarissa Geisheim , Kurt Hahlweg , Wolfgang Fiegenbaum , Monika Frank , Brigitte Schröder , Ines von Witzleben (2002). Das Brief Symptom Inventory (BSI) als Instrument zur Qualitätssicherung in der Psychotherapie . Diagnostica, 48(1), 28-36. Hogrefe Publishing Group.
    Type: Article DOI: 10.1026//0012-1924.48.1.28 OpenAlex: https://openalex.org/W2149421788
    Crossref OpenAlex
  54. Ruth Ashman , Kirsty Banks , Ruth C.M. Philip , Robert Walley , Andrew C. Stanfield (2017). A pilot randomised controlled trial of a group based social skills intervention for adults with autism spectrum disorder . Research in Autism Spectrum Disorders, 43-44, 67-75. Elsevier BV.
    Type: Article DOI: 10.1016/j.rasd.2017.08.001 OpenAlex: https://openalex.org/W2763823628
    Crossref OpenAlex
  55. Sven Bölte , Fritz Poustka , John N. Constantino (2008). Assessing autistic traits: cross‐cultural validation of the social responsiveness scale (SRS) . Autism Research, 1(6), 354-363. Wiley.
    Type: Article DOI: 10.1002/aur.49 OpenAlex: https://openalex.org/W2166649563
    Crossref OpenAlex
  56. A Gawronski , K Pfeiffer , K Vogeley (2013). Hochfunktionaler Autismus im Erwachsenenalter: Verhaltenstherapeutisches Gruppenmanual . PSYCH up2date, 7(03), 143-143. Georg Thieme Verlag KG.
    Type: Article DOI: 10.1055/s-0033-1336840 OpenAlex: https://openalex.org/W2728273453
    Crossref OpenAlex
  57. Barbara E. Bierer , Rebecca Li , Jonathan Seltzer , Lynn A. Sleeper , Elizabeth Frank , Charles Knirsch et al. (2016). Responsibilities of Data Monitoring Committees: Consensus Recommendations . Therapeutic Innovation & Regulatory Science, 50(5), 648-659. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1177/2168479016646812 OpenAlex: https://openalex.org/W2371099873
    Crossref OpenAlex
  58. Micah Mazurek , Jessica Pappagianopoulos , Sophie Brunt , Eleonora Sadikova , Rose Nevill , Michelle Menezes et al. (2023). A mixed methods study of autistic adults' mental health therapy experiences . Clinical Psychology & Psychotherapy, 30(4), 767-779. Wiley.
    Type: Article DOI: 10.1002/cpp.2835 OpenAlex: https://openalex.org/W4318323630
    Crossref OpenAlex
  59. THE WHOQOL GROUP (1998). Development of the World Health Organization WHOQOL-BREF Quality of Life Assessment . Psychological Medicine, 28(3), 551-558. Cambridge University Press (CUP).
    Type: Article DOI: 10.1017/s0033291798006667 OpenAlex: https://openalex.org/W2429180991
    Crossref OpenAlex
  60. (s. d.). Gemeinsamer Bundesausschuss. Beschluss über die Freigabe des Berichts „Überarbeitung der Patientenbefragung für das Qualitätssicherungsverfahren Ambulante Psychotherapie“ (IQTiG–Abschlussbericht). Berlin; 2024.
    Type: Autre
    Crossref
  61. Priya Ranganathan , CS Pramesh , Rakesh Aggarwal (2016). Common pitfalls in statistical analysis: Intention-to-treat versus per-protocol analysis . Perspectives in Clinical Research, 7(3), 144. Medknow.
    Type: Article DOI: 10.4103/2229-3485.184823 OpenAlex: https://openalex.org/W2474709579
    Crossref OpenAlex
  62. Fumiyo Oshima , Tomokazu Murata , Toshiyuki Ohtani , Mikuko Seto , Eiji Shimizu (2021). A preliminary study of schema therapy for young adults with high-functioning autism spectrum disorder: a single-arm, uncontrolled trial . BMC Research Notes, 14(1), 1. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/s13104-021-05556-1 OpenAlex: https://openalex.org/W3116172364
    Crossref OpenAlex
  63. Fumiyo Oshima , Will Mandy , Mikuko Seto , Minako Hongo , Aki Tsuchiyagaito , Yoshiyuki Hirano et al. (2023). Cognitive behavior therapy for autistic adolescents, awareness and care for my autistic traits program: a multicenter randomized controlled trial . BMC Psychiatry, 23(1), 661. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/s12888-023-05075-2 OpenAlex: https://openalex.org/W4386498785
    Crossref OpenAlex
  64. Antonio F. Pagán , Amanda Chang , Yasmine Bensidi-Slimane , Katherine A. Loveland (2025). Development of an integrated individual therapy approach for young adults with autism spectrum disorder . Research in Autism, 126, 202653. Elsevier BV.
    Type: Article DOI: 10.1016/j.reia.2025.202653 OpenAlex: https://openalex.org/W4411853605
    Crossref OpenAlex
  65. P. Retz-Junginger , W. Retz , D. Blocher , R.-D. Stieglitz , T. Georg , T. Supprian et al. (2003). Reliabilität und Validität der Wender-Utah-Rating-Scale-Kurzform . Der Nervenarzt, 74(11), 987-993. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s00115-002-1447-4 OpenAlex: https://openalex.org/W2619316636
    Crossref OpenAlex
  66. Pagan A (2025). Pagan A, Loveland K. A randomized controlled trial of the Launching! to adulthood program. 2025. https://clinicaltrials.gov/study/NCT06868537 . Accessed 16 Oct 2025.
    Type: Autre
    Crossref
  67. Isabel Dziobek (2024). Dziobek I, Stoll S. Hochfunktionaler Autismus bei Erwachsenen: ein kognitiv-verhaltenstherapeutisches Manual. 2nd edition. Kohlhammer; 2024.
    Type: Autre
    Crossref
  68. Isabel Dziobek (2025). Dziobek I, Küpper C. Kurzzeit-Psychotherapeutisches Einzelbehandlungskonzept für Erwachsene im Autismus-Spektrum - ein kognitiv-verhaltenstherapeutisches Behandlungsmanual (unpublished study manual). 2025.
    Type: Autre
    Crossref
  69. Manfred E. Beutel , Elmar Brähler , Jörg Wiltink , Matthias Michal , Eva M. Klein , Claus Jünger et al. (2017). Emotional and tangible social support in a German population-based sample: Development and validation of the Brief Social Support Scale (BS6) . PLOS ONE, 12(10), e0186516. Public Library of Science (PLoS).
    Type: Article DOI: 10.1371/journal.pone.0186516 OpenAlex: https://openalex.org/W2761402900
    Crossref OpenAlex
  70. Elsner B (2025). Kognitive Verhaltenstherapie im Einzelsetting für Autismus- Spektrum-Störungen in Erwachsenenalter: eine Pilotstudie. Oral presentation at the 4 . Kognitive Verhaltenstherapie im Einzelsetting für Autismus- Spektrum-Störungen in Erwachsenenalter: eine Pilotstudie. Oral presentation at the 4.
    Type: Autre
    Crossref
  71. Elsner B (s. d.). Cognitive behavioral therapy in individual settings for autism spectrum disorders in adulthood . Cognitive behavioral therapy in individual settings for autism spectrum disorders in adulthood.
    Type: Autre
    Crossref
  72. Helen McConachie , David Mason , Jeremy R. Parr , Deborah Garland , Colin Wilson , Jacqui Rodgers (2018). Enhancing the Validity of a Quality of Life Measure for Autistic People . Journal of Autism and Developmental Disorders, 48(5), 1596-1611. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-017-3402-z OpenAlex: https://openalex.org/W2768942203
    Crossref OpenAlex
  73. Isabel Dziobek , Silke Lipinski * (2021). Partizipative Forschung in Klinischer Psychologie und Psychiatrie in Deutschland – Erreichtes, Gelebtes und ein Blick nach vorne . Psychiatrische Praxis, 48(07), 337-340. Georg Thieme Verlag KG.
    Type: Article DOI: 10.1055/a-1614-0719 OpenAlex: https://openalex.org/W3202593771
    Crossref OpenAlex
  74. (s. d.). Autismus-Forschungs-Kooperation. Autismus-Forschungs-Kooperation - Partizipatorisches Forschen auf Augenhöhe. 2025. https://www.autismus-forschungs-kooperation.de/ .
    Type: Autre
    Crossref
  75. Thomas R Fleming , Susan S Ellenberg , David L DeMets (2018). Data Monitoring Committees: Current issues . Clinical Trials, 15(4), 321-328. SAGE Publications.
    Type: Article DOI: 10.1177/1740774518764855 OpenAlex: https://openalex.org/W2798258710
    Crossref OpenAlex
  76. Aspies eV (s. d.). Aspies e. V. Aspies e. V. - Menschen im Autismus-Spektrum. https://aspies.de/ .
    Type: Autre
    Crossref
  77. Poustka L (2015). Poustka L, Rühl D, Feineis-Matthews S, Bölte S, Poustka F, Hartung M. Diagnostische Beobachtungsskala für Autistische Störungen – 2. Deutschsprachige Fassung der Autism Diagnostic Observation Schedule – 2 von C. Lord, M. Rutter, P. C. DiLavore, S. Risi, K. Gotham und S. L. Bishop (Module 1–4) und C. Lord, R. J. Luyster, K. Gotham und W. Guthrie (Kleinkind-Modul). Göttingen: Hogrefe; 2015.
    Type: Autre
    Crossref
  78. Laura Hull , Will Mandy , Meng-Chuan Lai , Simon Baron-Cohen , Carrie Allison , Paula Smith et al. (2019). Development and Validation of the Camouflaging Autistic Traits Questionnaire (CAT-Q) . Journal of Autism and Developmental Disorders, 49(3), 819-833. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-018-3792-6 OpenAlex: https://openalex.org/W2898221520
    Crossref OpenAlex
  79. Sven Bölte (2006). Ann Le Couteur und Catherine Lord [Manual] . Ann Le Couteur und Catherine Lord [Manual].
    Type: Autre
    Crossref
  80. Beesdo-Baum K (2019). Strukturiertes Klinisches Interview für DSM-5- Störungen—Klinische Version . Strukturiertes Klinisches Interview für DSM-5- Störungen—Klinische Version.
    Type: Autre
    Crossref
  81. A. Heissel , J. Bollmann , M. Kangas , K. Abdulla , M. Rapp , A. Sanchez (2021). Validation of the German version of the work and social adjustment scale in a sample of depressed patients . BMC Health Services Research, 21(1), 593. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/s12913-021-06622-x OpenAlex: https://openalex.org/W3127050695
    Crossref OpenAlex
  82. Schmidt K (1992). Schmidt K, Metzler P. Wortschatztest (WST). 1st edition. Weinheim: Beltz; 1992.
    Type: Autre
    Crossref
  84. Christine Kuehner , Ferdinand Keller , Isabelle F. Schricker , Theresa Beddig , Silke Huffziger , Christina Timm et al. (2023). Diagnostische Performanz und Validität des deutschsprachigen BDI-II – Eine Sekundäranalyse mit Daten aus klinischen und nichtklinischen Stichproben . Psychiatrische Praxis, 50(01), 36-42. Georg Thieme Verlag KG.
    Type: Article DOI: 10.1055/a-1753-2298 OpenAlex: https://openalex.org/W4221026452
    Crossref OpenAlex
  85. Neil S. Jacobson , Paula Truax (1991). Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. Journal of Consulting and Clinical Psychology, 59(1), 12-19. American Psychological Association (APA).
    Type: Article DOI: 10.1037/0022-006x.59.1.12 OpenAlex: https://openalex.org/W4235813114
    Crossref OpenAlex
  86. Derogatis LR (1993). Brief Symptom Inventory . Eur J Psychol Assess.
    Type: Autre
    Crossref
  87. Ferdinand Keller , Christine Kühner , Rainer W. Alexandrowicz , Ulrich Voderholzer , Adrian Meule , Jörg M. Fegert et al. (2022). Zur Messqualität des Beck-Depressionsinventars (BDI-II) in unterschiedlichen klinischen Stichproben . Zeitschrift für Klinische Psychologie und Psychotherapie, 51(3-4), 234-246. Hogrefe Publishing Group.
    Type: Article DOI: 10.1026/1616-3443/a000676 OpenAlex: https://openalex.org/W4306402737
    Crossref OpenAlex
  88. Guy W (1976). Clinical Global Impression, ECDEU assessment manual for psychopharmacology . Clinical Global Impression, ECDEU assessment manual for psychopharmacology.
    Type: Autre
    Crossref
  89. Hanna Agius , Anne-Kristina Luoto , Anna Backman , Carina Eriksdotter , Nitya Jayaram-Lindström , Sven Bölte et al. (2024). Mindfulness-based stress reduction for autistic adults: A feasibility study in an outpatient context . Autism, 28(2), 403-414. SAGE Publications.
    Type: Article DOI: 10.1177/13623613231172809 OpenAlex: https://openalex.org/W4376641643
    Crossref OpenAlex
  90. Beck AT (1996). Beck Depression Inventory-II . Beck Depression Inventory-II.
    Type: Autre
    Crossref
  91. Stangier U (2005). Internationale Skalen für Psychiatrie (Internatioal Scales for Psychiatry) . Internationale Skalen für Psychiatrie (Internatioal Scales for Psychiatry), 299.
    Type: Autre
    Crossref
  92. Schütz A (2016). Multidimensionale Selbstwertskala (MSWS). 2., completely revised and newly standardized edition . Multidimensionale Selbstwertskala (MSWS). 2., completely revised and newly standardized edition.
    Type: Autre
    Crossref
  93. Schmidt J (1989). Zufriedenheit mit der stationären Versorgung. Entwicklung eines Fragebogens und erste Validitätsuntersuchungen . PPmP Psychother Psychosom Med Psychol.
    Type: Autre
    Crossref
  94. Schmidt J (2002). Diagnostische Verfahren in der Psychotherapie . Diagnostische Verfahren in der Psychotherapie, 392.
    Type: Autre
    Crossref
  95. Snow G (2013). Snow G, Snow MG. Package ‘blockrand.’ Compr R Arch Netw. 2013.
    Type: Autre
    Crossref
  96. Food (2021). U. S. Food & Drug Administration. Agency information collection activities; proposed collection; comment request; establishment and operation of clinical trial data monitoring committees. 2021. https://www.regulations.gov/document/FDA-2021-N-0356-0001 . Accessed 17 Oct 2025.
    Type: Autre
    Crossref
  97. Lin JY (2014). Lin JY, Lu Y. Establishing a Data Monitoring Committee for clinical trials. Shanghai Arch Psychiatry. 2014;26:54. https://doi.org/doi:%252010 . 3969/j.issn. 1002-0829. 2014. 01. 009.
    Type: Autre
    Crossref