Les traits autistiques sont associés à un rythme de vieillissement plus rapide : données issues de l’étude de Dunedin à l’âge de 45 ans

Titre original en anglais : Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45

Cette publication est incluse dans le projet « Contributions académiques de personnes autistes sur l’autisme ». un auteur·ice de cette publication est identifié·e comme autiste dans le projet.

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Mason, D., Ronald, A., Ambler, A., Caspi, A., Houts, R., Poulton, R., Ramrakha, S., Wertz, J., Moffitt, T. E., & Happé, F. (2021). Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45. Autism Research, 14(8), 1684-1694. https://doi.org/10.1002/aur.2534

Date de publication: 27/05/2021 Ajout dans AutiHub: 18/09/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
10
Auteur·ices de la publication identifié·es comme autistes
1 / 10 (10,0 %)
  1. David Mason *
  2. Angelica Ronald
  3. Antony Ambler
  4. Avshalom Caspi
  5. Renate Houts
  1. Richie Poulton
  2. Sandhya Ramrakha
  3. Jasmin Wertz
  4. Terrie E. Moffitt
  5. Francesca Happé

Résumé

Résumé Des données de plus en plus nombreuses indiquent que les caractéristiques définissant le trouble du spectre de l’autisme (TSA) sont réparties dans l’ensemble de la population générale ; par conséquent, comprendre les corrélats du vieillissement chez les personnes présentant des traits autistiques élevés pourrait éclairer le TSA et le vieillissement. 915 membres de la cohorte longitudinale de naissance de Dunedin ont rempli une mesure des traits autistiques à l’âge de 45 ans. Une mesure composite du « rythme de vieillissement » a été obtenue en suivant le déclin de 19 biomarqueurs aux âges de 26, 32, 38 et 45 ans. L’âge facial a également été évalué. Des évaluations de la santé perçue ont été recueillies auprès des participants eux-mêmes, d’informateurs et d’enquêteurs. Des traits autistiques autodéclarés plus élevés étaient significativement corrélés à un rythme de vieillissement plus rapide, à un âge facial plus élevé et à une santé évaluée comme moins bonne par les participants eux-mêmes, les informateurs et les enquêteurs. Après contrôle du sexe, du statut socioéconomique et du QI, les traits autistiques étaient significativement associés à chaque variable : rythme de vieillissement (β = 0.09), âge facial (β = 0.08), santé évaluée par les participants eux-mêmes (β = −0.15), par les informateurs (β = −0.12) et par les enquêteurs (β = −0.17). Les traits autistiques mesurés à l’âge de 45 ans sont associés à un vieillissement plus rapide. Les participants présentant des traits autistiques élevés semblent être plus vulnérables à des issues de santé défavorables, comme cela a été précédemment rapporté pour les personnes ayant reçu un diagnostic clinique de TSA. Par conséquent, les traits autistiques peuvent avoir des implications importantes pour la santé. La réplication de ces résultats dans des échantillons de personnes autistes est nécessaire afin d’identifier le mécanisme de leur effet sur le vieillissement et la santé physique, pour améliorer les résultats chez les personnes ayant un diagnostic de TSA ou des traits autistiques élevés. Résumé vulgarisé Le rôle des traits autistiques en relation avec les issues de santé n’a pas été étudié. Nous avons examiné comment la santé physique et le vieillissement, mesurés à l’aide de questions autodéclarées et du déclin de multiples mesures biologiques, étaient liés aux traits autistiques, mesurés par un questionnaire à l’âge de 45 ans. Nous avons constaté que des traits autistiques plus élevés étaient associés à de moins bonnes évaluations de la santé physique et à un rythme de vieillissement plus rapide. Cela suggère que les personnes autistes comme celles présentant des traits autistiques plus élevés pourraient être davantage susceptibles de connaître des issues de santé plus défavorables.

Abstract Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the “pace of aging” was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45 years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self‐reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self‐, informant‐, and interviewer‐rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (β = 0.09), facial age (β = 0.08), self‐ (β = −0.15), informant (β = −0.12), and interviewer‐rated (β = −0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. Lay Summary The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self‐reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes.

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Vue d’ensemble de la bibliographie citée

Ces indicateurs décrivent la bibliographie citée par cette publication. Un nom d’auteurice est compté chaque fois qu’il apparaît dans une référence citée : une même personne peut donc être comptée plusieurs fois. Les noms qui ne sont pas encore associés à un·e auteurice déjà présent·e dans AutiHub sont traités comme inconnus, pas comme non autistes. Dernier calcul : 02/10/2026 08:11.

Références citées
79
Avec un DOI
74
Sans DOI, à partir du texte brut de la bibliographie
4
3 / 79 (3,8 %) références citées comprennent au moins une personne identifiée comme autiste.
Références avec données à compléter
2 / 79 (2,5 %)
Références avec noms d’auteurices détectés
77 / 79 (97,5 %)
Sans nom d’auteurice détecté
2
Sans titre structuré
2
Sans identifiant stable
4
Références avec noms bruts d’auteurices restant à vérifier
0
Références avec problème de récupération des métadonnées externes
0
Ces indicateurs portent sur les références citées affichées sur cette page, après fusion des doublons techniques. Une référence sans DOI peut quand même soutenir les statistiques d’auteurices lorsqu’un titre et des noms d’auteurices sont disponibles.
Noms d’auteurices détectés dans la bibliographie citée
456
À partir du DOI ou de métadonnées externes
456
À partir du texte brut validé de la bibliographie
0
Noms bruts déjà validés
0
Noms bruts restant à vérifier
0
144 / 456 (31,6 %) noms sont associés à un·e auteurice déjà présent·e dans AutiHub. 312 / 456 (68,4 %) noms ne sont pas encore associés.
Noms associés à une personne identifiée comme autiste
4 / 456 (0,9 %)
Calculé sur l’ensemble des noms d’auteurices détectés dans la bibliographie citée. Parmi les noms associés à un·e auteurice déjà présent·e dans AutiHub : 4 / 144 (2,8 %). Personnes distinctes identifiées comme autistes : 3 / 338 (0,9 %).
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