Les réponses de prédiction et de négativité de discordance reflètent des altérations du traitement sémantique de l'action chez des adultes présentant des troubles du spectre de l'autisme

Titre original en anglais : Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders

Grisoni, L., Moseley, R., Motlagh, S., Kandia, D., Sener, N., Pulvermüller, F., Roepke, S., & Mohr, B. (2019). Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders. Frontiers in Human Neuroscience, 13, 395-395. https://doi.org/10.3389/fnhum.2019.00395

Date de publication: 14/11/2019 Ajout dans AutiHub: 06/07/2026 Type: Article Langue de l’article: Anglais

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Auteurs

Auteur·ices des publications
8
Auteur·ices de la publication identifié·es comme autistes
1 / 8 (12,5 %)

Résumé

Les mécanismes neurophysiologiques sous-tendant les difficultés motrices et langagières dans les troubles du spectre de l'autisme (TSA) restent encore largement incertains. Le présent travail étudie des indicateurs biologiques du traitement des sons, de la compréhension sémantique (de l'action) et du codage prédictif, ainsi que leur corrélation avec les symptômes cliniques des TSA. Vingt-deux adultes présentant un TSA de haut niveau de fonctionnement et 25 participants au développement typique (TD) ont participé à une tâche auditive passive d'écoute de négativité de discordance (MMN), tandis qu'une électroencéphalographie (EEG) à haute densité était enregistrée. Des mots d'action et de non-action ont été présentés dans le contexte de sons, qui étaient soit sémantiquement congruents au regard de la partie du corps à laquelle ils se rapportent, soit sémantiquement incongruents ou non apparentés. L'activité anticipatoire avant le début du son, le potentiel de prédiction (PP), était significativement réduite dans le groupe TSA spécifiquement pour les sons d'action, mais non pour les sons de non-action. Les réponses précoces de type MMN aux mots (latence : 120 ms) étaient modulées différemment selon les groupes : les témoins présentaient des amplitudes plus importantes pour les mots dans des contextes sonores d'action que dans des contextes de non-action, tandis que les participants TSA ne manifestaient des réponses précoces de type MMN accrues que dans un contexte de son pur, sans autre modulation dépendante du contexte sonore d'action. Les réponses tardives de type MMN, environ 560 ms après le début du stimulus, ont révélé un amorçage sémantique de l'action congruent avec la partie du corps pour les mots chez les participants témoins, mais non dans le groupe TSA. Il est important de noter que les indices neurophysiologiques d'amorçage sémantique chez les participants TSA étaient corrélés à l'ampleur des traits autistiques, telle que révélée par l'Autism Spectrum Quotient (AQ). Les données suggèrent que les adultes de haut niveau de fonctionnement présentant un TSA montrent un déficit spécifique du traitement sémantique et du codage prédictif des sons et des mots liés à l'action, qui est absent pour les sons neutres, de non-action.

The neurophysiological mechanisms underlying motor and language difficulties in autism spectrum disorders (ASD) are still largely unclear. The present work investigates biological indicators of sound processing, (action-) semantic understanding and predictive coding and their correlation with clinical symptoms of ASD. Twenty-two adults with high-functioning ASD and 25 typically developed (TD) participants engaged in an auditory, passive listening, Mismatch Negativity (MMN) task while high-density electroencephalography (EEG) was recorded. Action and non-action words were presented in the context of sounds, which were either semantically congruent with regard to the body part they relate to or semantically incongruent or unrelated. The anticipatory activity before sound onset, the Prediction Potential (PP), was significantly reduced in the ASD group specifically for action, but not for non-action sounds. The early-MMN-like responses to words (latency: 120 ms) were differentially modulated across groups: controls showed larger amplitudes for words in action-sound compared to non-action contexts, whereas ASD participants demonstrated enlarged early-MMN-like responses only in a pure tone context, with no other modulation dependent on action sound context. Late-MMN-like responses around 560 ms post-stimulus onset revealed body-part-congruent action-semantic priming for words in control participants, but not in the ASD group. Importantly, neurophysiological indices of semantic priming in ASD participants correlated with the extent of autistic traits as revealed by the Autism Spectrum Quotient (AQ). The data suggest that high-functioning adults with ASD show a specific deficit in semantic processing and predictive coding of sounds and words related to action, which is absent for neutral, non-action, sounds.

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Ces indicateurs décrivent la bibliographie citée importée pour cette publication. Les métriques de références citées utilisent le total des références citées comme dénominateur. Les métriques d’auteurices cité·es indiquent si elles utilisent toutes les occurrences d’auteurices cité·es ou seulement les occurrences rattachées à des auteurices déjà intégré·es à la base de données AutiHub. Ils utilisent les rattachements mis en cache entre les auteurices cité·es et les auteurices intégré·es à la base de données AutiHub. Dernier calcul : 16/08/2026 11:31.

Références citées
60
Nombre total de références citées intégrées pour cette publication.
Références citées avec un·e auteur·ice identifié·e comme autiste
5 / 60 (8,3 %)
Occurrences d’auteur·ices cité·es identifié·es comme autistes
5 / 226 (2,2 %)
Parmi les occurrences rattachées à des auteurices intégré·es à la base de données AutiHub : 5 / 67 (7,5 %). Auteurices cité·es distinct·es identifié·es comme autistes : 1 / 159 (0,6 %).
Occurrences citées rattachées à la base AutiHub
67 / 226 (29,6 %)
Auteurices cité·es distinct·es rattaché·es : 21 / 159 (13,2 %)
Occurrences rattachées, non identifiées comme autistes
62 / 67 (92,5 %)
Parmi les seules occurrences rattachées. Sur l’ensemble des occurrences d’auteurices cité·es : 62 / 226 (27,4 %). Auteurices cité·es distinct·es rattaché·es, non identifié·es comme autistes : 20 / 21 (95,2 %).
  1. Laura Sparaci , Silvia Stefanini , Lidia D'Elia , Stefano Vicari , Giacomo Rizzolatti (2014). What and Why Understanding in Autism Spectrum Disorders and W illiams Syndrome: Similarities and Differences . Autism Research, 7(4), 421-432. Wiley.
    Type: Article DOI: 10.1002/aur.1370 OpenAlex: https://openalex.org/W1500251818
    Crossref OpenAlex OpenCitations
  2. González Moreno, Andrés Santiago (2013). Diagnostic and Statistical Manual of Mental Disorders . American Psychiatric Association.
    Crossref OpenAlex OpenCitations
  3. Elizabeth Pellicano , David Burr (2012). When the world becomes ‘too real’: a Bayesian explanation of autistic perception . Trends in Cognitive Sciences, 16(10), 504-510. Elsevier BV.
    Crossref OpenAlex OpenCitations
  4. Martin H. Fischer , Rolf A. Zwaan (2008). Embodied Language: A Review of the Role of the Motor System in Language Comprehension . Quarterly Journal of Experimental Psychology, 61(6), 825-850. SAGE Publications.
    Crossref OpenAlex OpenCitations
  5. Simon Baron-Cohen (2009). Autism: The Empathizing–Systemizing (E‐S) Theory . Annals of the New York Academy of Sciences, 1156(1), 68-80. Wiley.
    Crossref OpenAlex OpenCitations
  6. Amanda Ludlow , Bettina Mohr , Antony Whitmore , Max Garagnani , Friedemann Pulvermüller , Roberto Gutierrez (2014). Auditory processing and sensory behaviours in children with autism spectrum disorders as revealed by mismatch negativity . Brain and Cognition, 86, 55-63. Elsevier BV.
    Crossref OpenAlex OpenCitations
  7. Simon Baron-Cohen , Sally Wheelwright , Richard Skinner , Joanne Martin , Emma Clubley (2001). The Autism-Spectrum Quotient (AQ): Evidence from Asperger Syndrome/High-Functioning Autism, Males and Females, Scientists and Mathematicians . Journal of Autism and Developmental Disorders, 31(1), 5-17. Springer Science and Business Media LLC.
    Crossref OpenAlex
  8. R. Näätänen , P. Paavilainen , T. Rinne , K. Alho (2007). The mismatch negativity (MMN) in basic research of central auditory processing: A review . Clinical Neurophysiology, 118(12), 2544-2590. Elsevier BV.
    Crossref OpenAlex OpenCitations
  9. Lawrence W. Barsalou (2008). Grounded Cognition . Annual Review of Psychology, 59(1), 617-645. Annual Reviews.
    Crossref OpenAlex OpenCitations
  10. Kimberly A. Fournier , Chris J. Hass , Sagar K. Naik , Neha Lodha , James H. Cauraugh (2010). Motor Coordination in Autism Spectrum Disorders: A Synthesis and Meta-Analysis . Journal of Autism and Developmental Disorders, 40(10), 1227-1240. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  11. Jacob Cohen (1973). Eta-Squared and Partial Eta-Squared in Fixed Factor Anova Designs . Educational and Psychological Measurement, 33(1), 107-112. SAGE Publications.
    Crossref OpenAlex OpenCitations
  12. Stewart H. Mostofsky , Joshua B. Ewen (2011). Altered Connectivity and Action Model Formation in Autism Is Autism . The Neuroscientist, 17(4), 437-448. SAGE Publications.
    Crossref OpenAlex OpenCitations
  13. Eira Jansson-Verkasalo , Rita Ceponiene , Marko Kielinen , Kalervo Suominen , Ville Jäntti , Sirkka-Liisa Linna et al. (2003). Deficient auditory processing in children with Asperger Syndrome, as indexed by event-related potentials . Neuroscience Letters, 338(3), 197-200. Elsevier BV.
    Crossref OpenAlex OpenCitations
  14. Cohen (1988). Statistical Power Analysis for the Behavioral Sciences. Statistical Power Analysis for the Behavioral Sciences.
    Type: Autre
    Crossref
  15. Friedemann Pulvermüller , Luciano Fadiga (2010). Active perception: sensorimotor circuits as a cortical basis for language . Nature Reviews Neuroscience, 11(5), 351-360. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/nrn2811 OpenAlex: https://openalex.org/W2076748564
    Crossref OpenAlex OpenCitations
  16. L�der Deecke , Peter Scheid , HansH. Kornhuber (1969). Distribution of readiness potential, pre-motion positivity, and motor potential of the human cerebral cortex preceding voluntary finger movements . Experimental Brain Research, 7(2), 158. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  17. Friedemann Pulvermüller , Yury Shtyrov , Risto J. Ilmoniemi , William D. Marslen-Wilson (2006). Tracking speech comprehension in space and time . NeuroImage, 31(3), 1297-1305. Elsevier BV.
    Crossref OpenAlex OpenCitations
  18. R. Näätänen , T. Kujala , C. Escera , T. Baldeweg , K. Kreegipuu , S. Carlson et al. (2012). The mismatch negativity (MMN) – A unique window to disturbed central auditory processing in ageing and different clinical conditions . Clinical Neurophysiology, 123(3), 424-458. Elsevier BV.
    Crossref OpenAlex OpenCitations
  19. Giacomo Rizzolatti , Corrado Sinigaglia (2010). The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations . Nature Reviews Neuroscience, 11(4), 264-274. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/nrn2805 OpenAlex: https://openalex.org/W1994585255
    Crossref OpenAlex OpenCitations
  20. Abigail Thompson , Declan Murphy , Flavio Dell’Acqua , Christine Ecker , Gráinne McAlonan , Henrietta Howells et al. (2017). Impaired Communication Between the Motor and Somatosensory Homunculus Is Associated With Poor Manual Dexterity in Autism Spectrum Disorder . Biological Psychiatry, 81(3), 211-219. Elsevier BV.
    Crossref OpenAlex OpenCitations
  21. Marie Gomot , Marie‐Hélène Giard , Jean‐Louis Adrien , Catherine Barthelemy , Nicole Bruneau (2002). Hypersensitivity to acoustic change in children with autism: Electrophysiological evidence of left frontal cortex dysfunctioning . Psychophysiology, 39(5), 577-584. Wiley.
    Crossref OpenCitations
  22. T. Kujala , T. Lepistö , R. Näätänen (2013). The neural basis of aberrant speech and audition in autism spectrum disorders . Neuroscience & Biobehavioral Reviews, 37(4), 697-704. Elsevier BV.
    Crossref OpenAlex OpenCitations
  23. James M Kilner , Claudia Vargas , Sylvie Duval , Sarah-Jayne Blakemore , Angela Sirigu (2004). Motor activation prior to observation of a predicted movement . Nature Neuroscience, 7(12), 1299-1301. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/nn1355 OpenAlex: https://openalex.org/W2012824684
    Crossref OpenAlex OpenCitations
  24. Samuel W. Greenhouse , Seymour Geisser (1959). On Methods in the Analysis of Profile Data . Psychometrika, 24(2), 95-112. Cambridge University Press (CUP).
    Crossref OpenAlex OpenCitations
  25. Teija Kujala , Mari Tervaniemi , Erich Schröger (2007). The mismatch negativity in cognitive and clinical neuroscience: Theoretical and methodological considerations . Biological Psychology, 74(1), 1-19. Elsevier BV.
    Crossref OpenAlex OpenCitations
  26. Tuulia Lepistö , Teija Kujala , Raija Vanhala , Paavo Alku , Minna Huotilainen , Risto Näätänen (2005). The discrimination of and orienting to speech and non-speech sounds in children with autism . Brain Research, 1066(1-2), 147-157. Elsevier BV.
    Crossref OpenAlex OpenCitations
  27. Luigi Grisoni , Felix R. Dreyer , Friedemann Pulvermüller (2016). Somatotopic Semantic Priming and Prediction in the Motor System . Cerebral Cortex, 26(5), 2353-2366. Oxford University Press (OUP).
    Crossref OpenAlex OpenCitations
  28. Giacomo Rizzolatti , Maddalena Fabbri-Destro (2010). Mirror neurons: from discovery to autism . Experimental Brain Research, 200(3-4), 223-237. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  29. Friedemann Pulvermüller , Teija Kujala , Yury Shtyrov , Jaana Simola , Hannu Tiitinen , Paavo Alku et al. (2001). Memory Traces for Words as Revealed by the Mismatch Negativity . NeuroImage, 14(3), 607-616. Elsevier BV.
    Crossref OpenAlex OpenCitations
  30. Luigi Grisoni , Tally McCormick Miller , Friedemann Pulvermüller (2017). Neural Correlates of Semantic Prediction and Resolution in Sentence Processing . The Journal of Neuroscience, 37(18), 4848-4858. Society for Neuroscience.
    Crossref OpenAlex OpenCitations
  31. Luigi Grisoni , Bettina Mohr , Friedemann Pulvermüller (2019). Prediction mechanisms in motor and auditory areas and their role in sound perception and language understanding . NeuroImage, 199, 206-216. Elsevier BV.
    Crossref OpenAlex OpenCitations
  32. Lucy J MacGregor , Friedemann Pulvermüller , Maarten van Casteren , Yury Shtyrov (2012). Ultra-rapid access to words in the brain . Nature Communications, 3(1), 711. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  33. Horn (1983). Leistungsprüfsystem: L-P-S. Leistungsprüfsystem: L-P-S..
    Type: Autre
    Crossref
  34. T. Lepistö , M. Kajander , R. Vanhala , P. Alku , M. Huotilainen , R. Näätänen et al. (2008). The perception of invariant speech features in children with autism . Biological Psychology, 77(1), 25-31. Elsevier BV.
    Crossref OpenAlex OpenCitations
  35. Marco Iacoboni (2009). Imitation, Empathy, and Mirror Neurons . Annual Review of Psychology, 60(1), 653-670. Annual Reviews.
    Crossref OpenAlex OpenCitations
  36. James M. Kilner , Karl J. Friston , Chris D. Frith (2007). Predictive coding: an account of the mirror neuron system . Cognitive Processing, 8(3), 159-166. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  37. Erich Schröger (1998). Measurement and interpretation of the mismatch negativity . Behavior Research Methods, Instruments, & Computers, 30(1), 131-145. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  38. Patricia K. Kuhl , Sharon Coffey‐Corina , Denise Padden , Géraldine Dawson (2005). Links between social and linguistic processing of speech in preschool children with autism: behavioral and electrophysiological measures . Developmental Science, 8(1), 1. Wiley.
    Crossref OpenAlex OpenCitations
  39. Megan MacDonald , Catherine Lord , Dale A. Ulrich (2014). Motor Skills and Calibrated Autism Severity in Young Children With Autism Spectrum Disorder . Adapted Physical Activity Quarterly, 31(2), 95-105. Human Kinetics.
    Crossref OpenAlex OpenCitations
  40. Jonathan Sussman-Fort , Elyse Sussman (2014). The effect of stimulus context on the buildup to stream segregation . Frontiers in Neuroscience, 8, 93. Frontiers Media SA.
    Crossref OpenAlex OpenCitations
  41. Justin H. G. Williams , Jackie M. Casey , Lieke Braadbaart , Peter R. Culmer , Mark Mon-Williams (2014). Kinematic Measures of Imitation Fidelity in Primary School Children . Journal of Cognition and Development, 15(2), 345-362. Informa UK Limited.
    OpenCitations
  42. Pawan Sinha , Margaret M. Kjelgaard , Tapan K. Gandhi , Kleovoulos Tsourides , Annie L. Cardinaux , Dimitrios Pantazis et al. (2014). Autism as a disorder of prediction . Proceedings of the National Academy of Sciences, 111(42), 15220-15225. National Academy of Sciences.
    Crossref OpenAlex OpenCitations
  43. Risto Näätänen , Elyse S. Sussman , Dean Salisbury , Valerie L. Shafer (2014). Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction . Brain Topography, 27(4), 451-466. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  44. Friedemann Pulvermüller , Yury Shtyrov (2006). Language outside the focus of attention: The mismatch negativity as a tool for studying higher cognitive processes . Progress in Neurobiology, 79(1), 49-71. Elsevier BV.
    Crossref OpenAlex OpenCitations
  45. Friedemann Pulvermüller , Rachel Moseley *Auteur·ice autiste. En savoir plus… , Natalia Egorova , Zubaida Shebani , Véronique Boulenger (2014). Motor cognition–motor semantics: Action perception theory of cognition and communication . Neuropsychologia, 55, 71-84. Elsevier BV.
    Crossref OpenAlex OpenCitations
  46. Sander Van de Cruys , Kris Evers , Ruth Van der Hallen , Lien Van Eylen , Bart Boets , Lee de-Wit et al. (2014). Precise minds in uncertain worlds: Predictive coding in autism. Psychological Review, 121(4), 649-675. American Psychological Association (APA).
    Type: Article DOI: 10.1037/a0037665 OpenAlex: https://openalex.org/W2098533845
    Crossref OpenAlex OpenCitations
  47. Yury Shtyrov , Olaf Hauk , Friedemann Pulvermüller (2004). Distributed neuronal networks for encoding category‐specific semantic information: the mismatch negativity to action words . European Journal of Neuroscience, 19(4), 1083-1092. Wiley.
    Crossref OpenAlex OpenCitations
  48. Lilly Schmidt , Jennifer Kirchner , Sandra Strunz , Julia Broźus , Kathrin Ritter , Stefan Roepke et al. (2015). Psychosocial Functioning and Life Satisfaction in Adults With Autism Spectrum Disorder Without Intellectual Impairment . Journal of Clinical Psychology, 71(12), 1259-1268. Wiley.
    Crossref OpenAlex OpenCitations
  49. Yury Shtyrov , Galina Goryainova , Sergei Tugin , Alexey Ossadtchi , Anna Shestakova (2013). Automatic processing of unattended lexical information in visual oddball presentation: neurophysiological evidence . Frontiers in Human Neuroscience, 7, 421. Frontiers Media SA.
    Crossref OpenAlex OpenCitations
  50. R.C. Oldfield (1971). The assessment and analysis of handedness: The Edinburgh inventory . Neuropsychologia, 9(1), 97-113. Elsevier BV.
    Crossref OpenAlex
  51. Friedemann Pulvermüller (2018). Neural reuse of action perception circuits for language, concepts and communication . Progress in Neurobiology, 160, 1-44. Elsevier BV.
    Crossref OpenAlex OpenCitations
  52. Friedemann Pulvermüller , Yury Shtyrov , Olaf Hauk (2009). Understanding in an instant: Neurophysiological evidence for mechanistic language circuits in the brain . Brain and Language, 110(2), 81-94. Elsevier BV.
    Crossref OpenAlex OpenCitations
  53. Isabelle Rapin , Michelle Dunn (2003). Update on the language disorders of individuals on the autistic spectrum . Brain and Development, 25(3), 166-172. Elsevier BV.
    Crossref OpenAlex OpenCitations
  54. Yury Shtyrov , Anna Butorina , Anastasia Nikolaeva , Tatiana Stroganova (2014). Automatic ultrarapid activation and inhibition of cortical motor systems in spoken word comprehension . Proceedings of the National Academy of Sciences, 111(18), E1918. National Academy of Sciences.
    Crossref OpenAlex OpenCitations
  55. Marie Gomot , Marie‐Hélène Giard , Jean‐Louis Adrien , Catherine Barthelemy , Nicole Bruneau (2002). Hypersensitivity to acoustic change in children with autism: Electrophysiological evidence of left frontal cortex dysfunctioning . Psychophysiology, 39(5), 577-584. Wiley.
    OpenAlex
  56. Keith Muller , Jacob Cohen (1989). Statistical Power Analysis for the Behavioral Sciences . Technometrics, 31(4), 499-500. Informa UK Limited.
    Type: Article DOI: 10.2307/1270020 OpenAlex: https://openalex.org/W4300870773
    OpenAlex