Une méta-analyse des études sur les résultats chez les adultes autistes : quantification de la taille d'effet, de la qualité et méta-régression

Titre original en anglais : A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression

Cette publication est incluse dans le projet « Contributions académiques de personnes autistes sur l’autisme ». un auteur·ice de cette publication est identifié·e comme autiste dans le projet.

À propos de la mention auteur·ice autiste

Mason, D., Capp, S. J., Stewart, G. R., Kempton, M. J., Glaser, K., Howlin, P., & Happé, F. (2020). A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression. Journal of Autism and Developmental Disorders, 51(9), 3165-3179. https://doi.org/10.1007/s10803-020-04763-2

Date de publication: 17/11/2020 Ajout dans AutiHub: 18/09/2026 Type: Article Langue de l’article: Anglais

Cette publication est intégrée dans AutiHub via :

Auteurs

Auteur·ices des publications
7
Auteur·ices de la publication identifié·es comme autistes
1 / 7 (14,3 %)

Résumé

Résumé Les études longitudinales ont généralement fait état de résultats médiocres à l'âge adulte pour la majorité des personnes (environ 50-60 %) autistes. Plusieurs facteurs prédiraient les résultats (p. ex., le QI), mais les conclusions restent mitigées. Cet article présente une méta-analyse actualisée des études sur les résultats de l'autisme et étend les résultats antérieurs par des analyses supplémentaires (y compris une méta-régression). Au total, 4 088 dossiers ont été examinés et 18 études, impliquant 1 199 personnes, ont été incluses dans l'analyse quantitative. Les pourcentages estimés indiquaient que 20,0 % des participants étaient évalués comme ayant un bon résultat, 26,6 % un résultat passable et 49,3 % un mauvais résultat. La méta-régression a indiqué qu'un QI plus faible à l'âge adulte prédisait un mauvais résultat ; les autres modèles de méta-régression n'ont pas résisté à la correction pour comparaisons multiples. Globalement, les résultats pour les personnes autistes sont en moyenne médiocres, et un QI plus élevé semble protéger contre un mauvais résultat. Les limites des conceptualisations actuelles du résultat sont discutées.

Abstract Longitudinal studies have generally reported poor outcomes in adulthood for the majority of individuals (c.50–60%) with autism. Several factors putatively predict outcome (e.g. IQ), but findings remain mixed. This paper presents an updated meta-analysis of autism outcome studies and extends previous findings with additional analyses (including meta-regression). A total of 4088 records was screened and 18 studies, involving 1199 individuals, were included in the quantitative analysis. Estimated percentages indicated that 20.0% of participants were rated as having a good outcome, 26.6% a fair outcome, and 49.3% a poor outcome. Meta-regression indicated that lower IQ in adulthood was predictive of poor outcome; other meta-regression models did not survive correction for multiple comparisons. Overall, outcomes for autistic people are on average poor, and higher IQ appears to be protective against having a poor outcome. The limitations of current constructs of outcome are discussed.

Bibliographie citée par cette référence

Les références citées sont importées depuis des sources externes de métadonnées lorsqu’elles sont disponibles. La liste peut être partielle.

Vue d’ensemble de la bibliographie citée

Ces indicateurs décrivent la bibliographie citée par cette publication. Un nom d’auteurice est compté chaque fois qu’il apparaît dans une référence citée : une même personne peut donc être comptée plusieurs fois. Les noms qui ne sont pas encore associés à un·e auteurice déjà présent·e dans AutiHub sont traités comme inconnus, pas comme non autistes. Dernier calcul : 02/10/2026 01:01.

Références citées
67
Avec un DOI
59
Sans DOI, à partir du texte brut de la bibliographie
5
2 / 67 (3,0 %) références citées comprennent au moins une personne identifiée comme autiste.
Références avec données à compléter
4 / 67 (6,0 %)
Références avec noms d’auteurices détectés
65 / 67 (97,0 %)
Sans nom d’auteurice détecté
2
Sans titre structuré
4
Sans identifiant stable
5
Références avec noms bruts d’auteurices restant à vérifier
0
Références avec problème de récupération des métadonnées externes
0
Ces indicateurs portent sur les références citées affichées sur cette page, après fusion des doublons techniques. Une référence sans DOI peut quand même soutenir les statistiques d’auteurices lorsqu’un titre et des noms d’auteurices sont disponibles.
Noms d’auteurices détectés dans la bibliographie citée
245
À partir du DOI ou de métadonnées externes
245
À partir du texte brut validé de la bibliographie
0
Noms bruts déjà validés
0
Noms bruts restant à vérifier
0
78 / 245 (31,8 %) noms sont associés à un·e auteurice déjà présent·e dans AutiHub. 167 / 245 (68,2 %) noms ne sont pas encore associés.
Noms associés à une personne identifiée comme autiste
2 / 245 (0,8 %)
Calculé sur l’ensemble des noms d’auteurices détectés dans la bibliographie citée. Parmi les noms associés à un·e auteurice déjà présent·e dans AutiHub : 2 / 78 (2,6 %). Personnes distinctes identifiées comme autistes : 2 / 201 (1,0 %).
  1. William B. Ware , John M. Ferron , Barbara M. Miller (2013). Introductory Statistics . Routledge.
    Crossref OpenAlex OpenCitations
  2. H Abdi (2007). Abdi, H. (2007). Bonferroni and Šidák corrections for multiple comparisons. Encyclopedia of Measurement and Statistics, 3, 103–107. Encyclopedia of Measurement and Statistics, 3, 103.
    Type: Autre
    Crossref
  3. I. Engström , L. Ekström , B. Emilsson (2003). Psychosocial Functioning in a Group of Swedish Adults with Asperger Syndrome or High- Functioning Autism . Autism, 7(1), 99-110. SAGE Publications.
    OpenAlex OpenCitations
  4. Andrew D. Althouse (2016). Adjust for Multiple Comparisons? It’s Not That Simple . The Annals of Thoracic Surgery, 101(5), 1644-1645. Elsevier BV.
    Crossref OpenAlex OpenCitations
  5. Victor Lotter (1974). Social adjustment and placement of autistic children in Middlesex: A follow-up study . Journal of Autism and Childhood Schizophrenia, 4(1), 11-32. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  6. John Goodier (2007). Encyclopedia of Measurement and Statistics . Reference Reviews, 21(8), 40-40. Emerald.
    OpenAlex
  7. González Moreno, Andrés Santiago (2013). Diagnostic and Statistical Manual of Mental Disorders . American Psychiatric Association.
    Crossref OpenAlex OpenCitations
  8. Helen McConachie , Nuala Livingstone , Christopher Morris , Bryony Beresford , Ann Le Couteur , Paul Gringras et al. (2018). Parents Suggest Which Indicators of Progress and Outcomes Should be Measured in Young Children with Autism Spectrum Disorder . Journal of Autism and Developmental Disorders, 48(4), 1041-1051. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  9. Suzanne L. West , Gerald Gartlehner , Alyssa J Mansfield , Charles Poole , Elizabeth Tant , Nancy Lenfestey et al. (2010). Comparative Effectiveness Review Methods: Clinical Heterogeneity .
    Type: Article OpenAlex: https://openalex.org/W1567299047
    OpenAlex
  10. Deborah K. Anderson , Jessie W. Liang , Catherine Lord (2014). Predicting young adult outcome among more and less cognitively able individuals with autism spectrum disorders . Journal of Child Psychology and Psychiatry, 55(5), 485-494. Wiley.
    Crossref OpenAlex OpenCitations
  11. Marian K. DeMyer , Sandra Barton , William E. DeMyer , James A. Norton , John Allen , Robert Steele (1973). Prognosis in autism: A follow-up study . Journal of Autism and Childhood Schizophrenia, 3(3), 199-246. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  12. Suhail A.R. Doi , Jan J. Barendregt , Shahjahan Khan , Lukman Thalib , Gail M. Williams (2015). Advances in the meta-analysis of heterogeneous clinical trials I: The inverse variance heterogeneity model . Contemporary Clinical Trials, 45(Pt A), 130-138. Elsevier BV.
    Crossref OpenAlex OpenCitations
  13. Kristy A. Anderson , Paul Shattuck , Benjamin P Cooper , Anne M. Roux , Mary Wagner (2014). Prevalence and correlates of postsecondary residential status among young adults with an autism spectrum disorder . Autism, 18(5), 562-570. SAGE Publications.
    Crossref OpenAlex OpenCitations
  14. Danny Ruta , Laura Camfield , Cam Donaldson (2007). Sen and the art of quality of life maintenance: Towards a general theory of quality of life and its causation . The Journal of Socio-Economics, 36(3), 397-423. Elsevier BV.
    Crossref OpenAlex OpenCitations
  15. Jan J Barendregt , Suhail A Doi , Yong Yi Lee , Rosana E Norman , Theo Vos (2013). Meta-analysis of prevalence . Journal of Epidemiology and Community Health, 67(11), 974-978. BMJ.
    Type: Article DOI: 10.1136/jech-2013-203104
    Crossref OpenCitations
  16. Emily Simonoff , Rachel Kent , Dominic Stringer , Catherine Lord , Jackie Briskman , Steve Lukito et al. (2020). Trajectories in Symptoms of Autism and Cognitive Ability in Autism From Childhood to Adult Life: Findings From a Longitudinal Epidemiological Cohort . Journal of the American Academy of Child & Adolescent Psychiatry, 59(12), 1342-1352. Elsevier BV.
    Crossref OpenAlex OpenCitations
  17. Eva Billstedt , Carina Gillberg , Christopher Gillberg (2005). Autism after Adolescence: Population-based 13- to 22-year Follow-up Study of 120 Individuals with Autism Diagnosed in Childhood . Journal of Autism and Developmental Disorders, 35(3), 351-360. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  18. Julie Lounds Taylor (2017). When is a good outcome actually good? Autism, 21(8), 918-919. SAGE Publications.
    Crossref OpenAlex OpenCitations
  19. Lisa A. Ruble , Nancy J. Dalrymple (1996). An Alternative View of Outcome in Autism . Focus on Autism and Other Developmental Disabilities, 11(1), 3-14. SAGE Publications.
    Crossref OpenAlex OpenCitations
  20. Lauren Bishop-Fitzpatrick , Jinkuk Hong , Leann E. Smith , Renee A. Makuch , Jan S. Greenberg , Marsha R. Mailick (2016). Characterizing Objective Quality of Life and Normative Outcomes in Adults with Autism Spectrum Disorder: An Exploratory Latent Class Analysis . Journal of Autism and Developmental Disorders, 46(8), 2707-2719. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  21. Megan A. Farley , William M. McMahon , Éric Fombonne , William R. Jenson , Judith S. Miller , Michael Gardner et al. (2009). Twenty‐year outcome for individuals with autism and average or near‐average cognitive abilities . Autism Research, 2(2), 109-118. Wiley.
    Type: Article DOI: 10.1002/aur.69 OpenAlex: https://openalex.org/W1983204707
    Crossref OpenAlex OpenCitations
  22. Michael Borenstein , Julian P. T. Higgins , Larry V. Hedges , Hannah R. Rothstein (2017). Basics of meta‐analysis: I 2 is not an absolute measure of heterogeneity . Research Synthesis Methods, 8(1), 5-18. Wiley.
    Crossref OpenAlex OpenCitations
  23. Paul Shattuck , Tamara Garfield , Anne M. Roux , Jessica E. Rast , Kristy A. Anderson , ELIZABETH M. HASSRICK et al. (2020). Services for Adults With Autism Spectrum Disorder: a Systems Perspective . Current Psychiatry Reports, 22(3), 13. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  24. Kenneth J. Rothman (1990). No Adjustments Are Needed for Multiple Comparisons . Epidemiology, 1(1), 43. Ovid Technologies (Wolters Kluwer Health).
    Crossref OpenAlex
  25. Mats Cederlund , Bibbi Hagberg , Eva Billstedt , I. Carina Gillberg , Christopher Gillberg (2008). Asperger Syndrome and Autism: A Comparative Longitudinal Follow-Up Study More than 5 Years after Original Diagnosis . Journal of Autism and Developmental Disorders, 38(1), 72-85. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  26. Brigitte Chamak , Béatrice Bonniau (2016). Trajectories, Long-Term Outcomes and Family Experiences of 76 Adults with Autism Spectrum Disorder . Journal of Autism and Developmental Disorders, 46(3), 1084-1095. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  27. Patricia Howlin , Philippa Moss , Sarah Savage , Michael Rutter (2013). Social Outcomes in Mid- to Later Adulthood Among Individuals Diagnosed With Autism and Average Nonverbal IQ as Children . Journal of the American Academy of Child & Adolescent Psychiatry, 52(6), 572-581.e1. Elsevier BV.
    Crossref OpenAlex OpenCitations
  28. John N Constantino , Tony Charman (2016). Diagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression . The Lancet Neurology, 15(3), 279-291. Elsevier BV.
    Crossref OpenAlex OpenCitations
  29. Sadao Otsuka , Shota Uono , Sayaka Yoshimura , Shuo Zhao , Motomi Toichi (2017). Emotion Perception Mediates the Predictive Relationship Between Verbal Ability and Functional Outcome in High-Functioning Adults with Autism Spectrum Disorder . Journal of Autism and Developmental Disorders, 47(4), 1166-1182. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  30. David Moher , Alessandro Liberati , Jennifer Tetzlaff , Doug Altman , the PRISMA Group* (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement . Annals of Internal Medicine, 151(4), 264-269. American College of Physicians.
    Crossref OpenAlex OpenCitations
  31. Linda C. Eaves , Helena H. Ho (2008). Young Adult Outcome of Autism Spectrum Disorders . Journal of Autism and Developmental Disorders, 38(4), 739-747. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  32. Andy P. Siddaway , Alex M. Wood , Larry V. Hedges (2019). How to Do a Systematic Review: A Best Practice Guide for Conducting and Reporting Narrative Reviews, Meta-Analyses, and Meta-Syntheses . Annual Review of Psychology, 70(1), 747-770. Annual Reviews.
    Crossref OpenAlex OpenCitations
  33. Michael Rutter , David Greenfeld , Linda Lockyer (1967). A Five to Fifteen Year Follow-Up Study of Infantile Psychosis . British Journal of Psychiatry, 113(504), 1183-1199. Royal College of Psychiatrists.
    Crossref OpenAlex OpenCitations
  34. S H Downs , N Black (1998). The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. Journal of Epidemiology and Community Health, 52(6), 377-384. BMJ.
    Crossref OpenAlex OpenCitations
  35. Patricia Howlin , Susan Goode , Jane Hutton , Michael Rutter (2004). Adult outcome for children with autism . Journal of Child Psychology and Psychiatry, 45(2), 212-229. Wiley.
    Crossref OpenAlex OpenCitations
  36. F. W. Larsen , S. E. Mouridsen (1997). The outcome in children with childhood autism and Asperger syndrome originally diagnosed as psychotic. A 30-year follow-up study of subjects hospitalized as children . European Child & Adolescent Psychiatry, 6(4), 181-190. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  37. I Engström (2003). Engström, I., Ekström, L., & Emilsson, B. (2003). Psychosocial functioning in a group of Swedish adults with Asperger syndrome or high-functioning autism. Autism, 7(1), 99–110. Autism, 7(1), 99.
    Type: Autre
    Crossref
  38. Julian P T Higgins , Simon G Thompson , Jonathan J Deeks , Doug Altman (2003). Measuring inconsistency in meta-analyses . BMJ, 327(7414), 557-560. BMJ.
    Crossref OpenAlex OpenCitations
  39. Ryuji Kobayashi , Toyohisa Murata , Kazuhiko Yoshinaga (1992). A follow-up study of 201 children with autism in Kyushu and Yamaguchi areas, Japan . Journal of Autism and Developmental Disorders, 22(3), 395-411. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  40. EpiGear. (2016). MetaXL. (version 5. 3 ed.). Queensland, Australia: EpiGear International Pty Ltd.
    Type: Autre
    Crossref
  41. Kristen Gillespie-Lynch , Leigh Sepeta , Yueyan Wang , Stephanie Marshall , Lovella Gomez , Marian Sigman et al. (2012). Early Childhood Predictors of the Social Competence of Adults with Autism . Journal of Autism and Developmental Disorders, 42(2), 161-174. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  42. Anna J. Esbensen , Somer Bishop , Marsha Mailick Seltzer , Jan S. Greenberg , Julie Lounds Taylor (2010). Comparisons Between Individuals With Autism Spectrum Disorders and Individuals With Down Syndrome in Adulthood . American Journal on Intellectual and Developmental Disabilities, 115(4), 277-290. Informa UK Limited.
    Crossref OpenAlex OpenCitations
  43. Adam Helles , I Carina Gillberg , Christopher Gillberg , Eva Billstedt (2017). Asperger syndrome in males over two decades: Quality of life in relation to diagnostic stability and psychiatric comorbidity . Autism, 21(4), 458-469. SAGE Publications.
    Crossref OpenAlex OpenCitations
  44. Christopher Gillberg , Suzanne Steffenburg (1987). Outcome and prognostic factors in infantile autism and similar conditions: A population-based study of 46 cases followed through puberty . Journal of Autism and Developmental Disorders, 17(2), 273-287. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  45. Megan Farley , Kristina J. Cottle , Deborah Bilder , Joseph Viskochil , Hilary Coon , William McMahon (2018). Mid‐life social outcomes for a population‐based sample of adults with ASD . Autism Research, 11(1), 142-152. Wiley.
    Type: Article DOI: 10.1002/aur.1897 OpenAlex: https://openalex.org/W2778639720
    Crossref OpenAlex OpenCitations
  46. Anne V. Kirby , Grace T. Baranek , Leslie Fox (2016). Longitudinal Predictors of Outcomes for Adults With Autism Spectrum Disorder . OTJR: Occupational Therapy Journal of Research, 36(2), 55-64. SAGE Publications.
    Crossref OpenAlex OpenCitations
  47. Stelios Georgiades , CONNIE KASARI (2018). Reframing Optimal Outcomes in Autism . JAMA Pediatrics, 172(8), 716. American Medical Association (AMA).
    Crossref OpenAlex OpenCitations
  48. Iliana Magiati , Xiang Wei Tay , Patricia Howlin (2014). Cognitive, language, social and behavioural outcomes in adults with autism spectrum disorders: A systematic review of longitudinal follow-up studies in adulthood . Clinical Psychology Review, 34(1), 73-86. Elsevier BV.
    Crossref OpenAlex OpenCitations
  49. Isaia Sevaslidou , Christina Chatzidimitriou , Grigoris Abatzoglou (2019). The long-term outcomes of a cohort of adolescents and adults from Greece with autism spectrum disorder . Annals of General Psychiatry, 18(1), 26. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  50. Natalie A. Henninger , Julie Lounds Taylor (2013). Outcomes in adults with autism spectrum disorders: a historical perspective . Autism, 17(1), 103-116. SAGE Publications.
    Crossref OpenAlex OpenCitations
  51. Marsha Mailick Seltzer , Marty Wyngaarden Krauss , Paul Shattuck , Gael Orsmond , April Swe , Catherine Lord (2003). The Symptoms of Autism Spectrum Disorders in Adolescence and Adulthood . Journal of Autism and Developmental Disorders, 33(6), 565-581. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  52. Nikolaos A Patsopoulos , Evangelos Evangelou , John PA Ioannidis (2008). Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation . International Journal of Epidemiology, 37(5), 1148-1157. Oxford University Press (OUP).
    Crossref OpenAlex OpenCitations
  53. Patricia Howlin , Iliana Magiati (2017). Autism spectrum disorder . Current Opinion in Psychiatry, 30(2), 69-76. Ovid Technologies (Wolters Kluwer Health).
    Crossref OpenAlex OpenCitations
  54. Sigrídur Lóa Jónsdóttir , Birta Brynjarsdóttir , Evald Saemundsen , Jón Fridrik Sigurdsson (2018). Long-term outcome of children with autism who received different forms of early intervention during their preschool years: a pilot study of 15 young adults . Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 6(1), 28-39. Walter de Gruyter GmbH.
    Crossref OpenAlex OpenCitations
  55. H. ‐C. Steinhausen , C. Mohr Jensen , M. B. Lauritsen (2016). A systematic review and meta‐analysis of the long‐term overall outcome of autism spectrum disorders in adolescence and adulthood . Acta Psychiatrica Scandinavica, 133(6), 445-452. Wiley.
    Crossref OpenAlex OpenCitations
  56. Barbara FC van Heijst , Hilde M. Geurts (2015). Quality of life in autism across the lifespan: A meta-analysis . Autism, 19(2), 158-167. SAGE Publications.
    Crossref OpenAlex OpenCitations
  57. Amanda Roestorf , Dermot Bowler , M.K. Deserno , Patricia Howlin , L. Klinger , Helen McConachie et al. (2019). “Older Adults with ASD: The Consequences of Aging.” Insights from a series of special interest group meetings held at the International Society for Autism Research 2016–2017 . Research in Autism Spectrum Disorders, 63, 3-12. Elsevier BV.
    Crossref OpenAlex OpenCitations
  58. Janet B W Williams , Michael First (2013). Diagnostic and Statistical Manual of Mental Disorders . Encyclopedia of Social Work. Oxford University PressNew York, NY.
    OpenAlex
  59. Julie Lounds Taylor , Natalie A Henninger , Marsha R Mailick (2015). Longitudinal patterns of employment and postsecondary education for adults with autism and average-range IQ . Autism, 19(7), 785-793. SAGE Publications.
    Crossref OpenAlex OpenCitations
  60. Philippa Moss , Will Mandy , Patricia Howlin (2017). Child and Adult Factors Related to Quality of Life in Adults with Autism . Journal of Autism and Developmental Disorders, 47(6), 1830-1837. Springer Science and Business Media LLC.
    Crossref OpenAlex OpenCitations
  61. Andrew Pickles , James B. McCauley , Lauren A. Pepa , Marisela Huerta , Catherine Lord (2020). The adult outcome of children referred for autism: typology and prediction from childhood . Journal of Child Psychology and Psychiatry, 61(7), 760-767. Wiley.
    Crossref OpenAlex OpenCitations
  62. Marcia Jean Carter (2014). Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Therapeutic Recreation Journal, 48(3).
    Type: Article OpenAlex: https://openalex.org/W2906253013
    OpenAlex
  63. StataCorp (2019). Stata Statistical Software: Release 16 . Stata Statistical Software: Release 16.
    Type: Autre
    Crossref
  64. David Moher , Alessandro Liberati , Jennifer Tetzlaff , Doug Altman (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. PubMed, 3(3), e123-30.
    Type: Article OpenAlex: https://openalex.org/W2991792334
    OpenAlex
  65. West, S. L., Gartlehner, G., Mansfield, A. J., Poole, C., Tant, E., Lenfestey, N., et al. (2010). Comparative effectiveness review methods: Clinical heterogeneity.
    Type: Autre
    Crossref