Rapport bref : caractérisation des comorbidités médicales avant le diagnostic d’autisme chez les enfants avant l’âge de deux ans

Titre original en anglais : Brief Report: The Characterization of Medical Comorbidity Prior to Autism Diagnosis in Children Before Age Two

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Eyoh, E. E., Failla, M. D., Williams, Z. J., Schwartz, K. L., Cutting, L. E., Landman, B. A., & Cascio, C. J. (2021). Brief Report: The Characterization of Medical Comorbidity Prior to Autism Diagnosis in Children Before Age Two. Journal of Autism and Developmental Disorders, 53(6), 2540-2547. https://doi.org/10.1007/s10803-021-05380-3

Date de publication: 01/12/2021 Ajout dans AutiHub: 07/07/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
7
Auteur·ices de la publication identifié·es comme autistes
1 / 7 (14,3 %)
  1. Ekomobong E. Eyoh
  2. Michelle D. Failla
  3. Zachary J. Williams *
  4. Kyle L. Schwartz
  1. Laurie E. Cutting
  2. Bennett A. Landman
  3. Carissa J. Cascio

Résumé

Dans le trouble du spectre de l’autisme (TSA), les affections médicales durant la petite enfance pourraient constituer des marqueurs prédictifs d’un diagnostic ultérieur de TSA. Dans cette étude, les dossiers médicaux électroniques de 579 personnes autistes et de 1897 témoins appariés avant l’âge de 2 ans ont été analysés afin d’identifier des affections potentiellement prédictives. À l’aide d’un nouvel outil, l’association relative de chaque affection dans le groupe autiste a été comparée à celle du groupe témoin au moyen de régressions logistiques appliquées aux dossiers médicaux. L’épilepsie convulsive généralisée, le nystagmus, l’absence de développement physiologique normal, le retard des étapes du développement et le strabisme étaient plus probables chez les personnes ayant reçu ultérieurement un diagnostic de TSA, tandis que l’ictère périnatal était moins susceptible d’être associé. Des affections moins connues, telles que le strabisme et le nystagmus, pourraient indiquer de nouveaux profils prédictifs d’affections concomitantes susceptibles d’améliorer les pratiques de dépistage du TSA.

In autism spectrum disorder (ASD), medical conditions in infancy could be predictive markers for later ASD diagnosis. In this study, electronic medical records of 579 autistic individuals and 1897 matched controls prior to age 2 were analyzed for potential predictive conditions. Using a novel tool, the relative association of each condition in the autistic group was compared to the control group using logistic regressions across medical records. Generalized convulsive epilepsy, nystagmus, lack of normal physiological development, delayed milestones, and strabismus were more likely in those later diagnosed with ASD while perinatal jaundice was less likely to be associated. Lesser-known conditions, such as strabismus and nystagmus, may point to novel predictive co-occurring condition profiles which could improve screening practices for ASD.

Bibliographie citée par cette référence

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Vue d’ensemble de l’inclusion dans la bibliographie

Ces indicateurs décrivent la bibliographie citée importée pour cette publication. Les métriques de références citées utilisent le total des références citées comme dénominateur. Les métriques d’auteurices cité·es indiquent si elles utilisent toutes les occurrences d’auteurices cité·es ou seulement les occurrences rattachées à des auteurices déjà intégré·es à la base de données AutiHub. Ils utilisent les rattachements mis en cache entre les auteurices cité·es et les auteurices intégré·es à la base de données AutiHub. Dernier calcul : 16/08/2026 11:31.

Références citées
37
Nombre total de références citées intégrées pour cette publication.
Références citées avec un·e auteur·ice identifié·e comme autiste
1 / 37 (2,7 %)
Occurrences d’auteur·ices cité·es identifié·es comme autistes
1 / 233 (0,4 %)
Parmi les occurrences rattachées à des auteurices intégré·es à la base de données AutiHub : 1 / 25 (4,0 %). Auteurices cité·es distinct·es identifié·es comme autistes : 1 / 222 (0,5 %).
Occurrences citées rattachées à la base AutiHub
25 / 233 (10,7 %)
Auteurices cité·es distinct·es rattaché·es : 20 / 222 (9,0 %)
Occurrences rattachées, non identifiées comme autistes
24 / 25 (96,0 %)
Parmi les seules occurrences rattachées. Sur l’ensemble des occurrences d’auteurices cité·es : 24 / 233 (10,3 %). Auteurices cité·es distinct·es rattaché·es, non identifié·es comme autistes : 19 / 20 (95,0 %).
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