Étude comparative des potentiels liés aux événements de la performance dans une tâche visuelle d'oddball chez des enfants présentant un trouble du spectre de l'autisme, un TDAH, un autisme et un TDAH comorbides, et chez des enfants neurotypiques
Titre original en anglais : Comparative Event-related Potential Study of Performance in Visual Oddball Task in Children with Autism Spectrum Disorder, ADHD, comorbid Autism and ADHD, and Neurotypical Children
Cette publication est incluse dans le projet « Contributions académiques de personnes autistes sur l’autisme ». un auteur·ice de cette publication est identifié·e comme autiste dans le projet.
À propos de la mention auteur·ice autisteSokhadze, E. M., Sears, L., Tasman, A., Casanova, M., & Casanova, M. F. (2019). Comparative Event-related Potential Study of Performance in Visual Oddball Task in Children with Autism Spectrum Disorder, ADHD, comorbid Autism and ADHD, and Neurotypical Children. NeuroRegulation, 6(3), 134. https://doi.org/10.15540/nr.6.3.134
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Résumé
Le trouble du spectre de l'autisme (TSA) et le trouble déficitaire de l'attention avec hyperactivité (TDAH) sont les troubles neurodéveloppementaux les plus fréquemment diagnostiqués. Bien que la comorbidité ait été exclue dans le DSM-IV (APA, 2000), le DSM-5 (APA, 2013) n'empêche pas le diagnostic concomitant de TSA et de TDAH (TSA+TDAH). Cette étude visait à comprendre les distinctions entre les déficits exécutifs associés à ces affections. Nous avons utilisé l'analyse du temps de réaction (TR) et des potentiels liés aux événements (PLE) pendant la réalisation d'une tâche d'oddball comportant des figures illusoires. Les participants étaient des enfants (N = 18 par groupe) présentant un TSA, un TDAH, un TSA+TDAH, ainsi que des témoins neurotypiques (CNT). L'analyse a révélé que les groupes TSA et TSA+TDAH commettaient davantage d'erreurs et présentaient des taux plus élevés d'erreurs par omission. Le TR après erreur dans les groupes TSA et TSA+TDAH se manifestait par une accélération de la réponse après erreur plutôt que par le ralentissement normatif du TR. Les groupes TSA et TSA+TDAH ont montré une négativité liée à l'erreur (ERN) atténuée par rapport au groupe TDAH et aux témoins. La N100 frontale était augmentée en réponse aux figures cibles et non cibles dans les groupes TSA et TSA+TDAH. Les PLE frontaux présentaient des latences prolongées dans le groupe TDAH par rapport aux autres groupes. L'étude a confirmé l'utilité des PLE pour élucider les différences entre le TSA et le TDAH ainsi que leur impact dans le diagnostic double. Ces informations contribuent à définir l'étendue du chevauchement entre ces affections, tant en termes d'expression des symptômes que de neuropathologie sous-jacente.
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