Neurosciences translationnelles dans l'autisme

Titre original en anglais : Translational Neuroscience in Autism

Cette publication est incluse dans le projet « Contributions académiques de personnes autistes sur l’autisme ». un auteur·ice de cette publication est identifié·e comme autiste dans le projet.

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Casanova, M. F., Sokhadze, E. M., Casanova, M., Opris, I., Abujadi, C., Marcolin, M. A., & Li, X. (2020). Translational Neuroscience in Autism. Psychiatric Clinics of North America, 43(2), 229-248. https://doi.org/10.1016/j.psc.2020.02.004

Publication date: 08/04/2020 Ajout dans AutiHub: 14/09/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
7
Auteur·ices de la publication identifié·es comme autistes
1 / 7 (14,3 %)
  1. Manuel F. Casanova
  2. Estate M Sokhadze
  3. Manuel Casanova *
  4. Ioan Opris
  1. Caio Abujadi
  2. Marco Antonio Marcolin
  3. Xiaoli Li

Résumé

La présence d'hétérotopies, d'une densité régionale accrue de neurones à la jonction entre la substance grise et la substance blanche, et de dysplasies corticales focales suggèrent toutes une anomalie de la migration neuronale dans le trouble du spectre de l'autisme (TSA). Cette anomalie résulte d'une discordance temporelle entre les neuroblastes migrant radialement et tangentiellement vers la plaque corticale en développement. Le découplage des cellules corticales excitatrices et inhibitrices perturbe les interactions coordonnées des neurones au sein des réseaux locaux, produisant ainsi des profils anormaux d'activité des ondes cérébrales dans la bande gamma. Dans le TSA, les anomalies des oscillations gamma et les marqueurs autonomes offrent des mesures des progrès thérapeutiques et contribuent à l'identification de sous-groupes.

The presence of heterotopias, increased regional density of neurons at the gray-white matter junction, and focal cortical dysplasias all suggest an abnormality of neuronal migration in autism spectrum disorder (ASD). The abnormality is borne from a dissonance in timing between radial and tangentially migrating neuroblasts to the developing cortical plate. The uncoupling of excitatory and inhibitory cortical cells disturbs the coordinated interactions of neurons within local networks, thus providing abnormal patterns of brainwave activity in the gamma bandwidth. In ASD, gamma oscillation abnormalities and autonomic markers offer measures of therapeutic progress and help in the identification of subgroups.

Bibliographie citée par cette référence

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Vue d’ensemble de la bibliographie citée

Ces indicateurs décrivent la bibliographie citée par cette publication. Un nom d’auteurice est compté chaque fois qu’il apparaît dans une référence citée : une même personne peut donc être comptée plusieurs fois. Les noms qui ne sont pas encore associés à un·e auteurice déjà présent·e dans AutiHub sont traités comme inconnus, pas comme non autistes. Dernier calcul : 14/09/2026 14:22.

Références citées
121
Avec un DOI
110
Sans DOI, à partir du texte brut de la bibliographie
10
2 / 121 (1,7 %) références citées comprennent au moins une personne identifiée comme autiste.
Références avec données à compléter
1 / 121 (0,8 %)
Références avec noms d’auteurices détectés
120 / 121 (99,2 %)
Sans nom d’auteurice détecté
1
Sans titre structuré
0
Sans identifiant stable
6
Références avec noms bruts d’auteurices restant à vérifier
0
Références avec problème de récupération des métadonnées externes
1
Ces indicateurs portent sur les références citées affichées sur cette page, après fusion des doublons techniques. Une référence sans DOI peut quand même soutenir les statistiques d’auteurices lorsqu’un titre et des noms d’auteurices sont disponibles.
Noms d’auteurices détectés dans la bibliographie citée
539
À partir du DOI ou de métadonnées externes
539
À partir du texte brut validé de la bibliographie
0
Noms bruts déjà validés
0
Noms bruts restant à vérifier
0
103 / 539 (19,1 %) noms sont associés à un·e auteurice déjà présent·e dans AutiHub. 436 / 539 (80,9 %) noms ne sont pas encore associés.
Noms associés à une personne identifiée comme autiste
3 / 539 (0,6 %)
Calculé sur l’ensemble des noms d’auteurices détectés dans la bibliographie citée. Parmi les noms associés à un·e auteurice déjà présent·e dans AutiHub : 3 / 103 (2,9 %). Personnes distinctes identifiées comme autistes : 2 / 430 (0,5 %).
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