Connectivite laterale atypique : une base neuronale pour un traitement visuospatial modifie dans l'autisme

Titre original en anglais : Atypical Lateral Connectivity: A Neural Basis for Altered Visuospatial Processing in Autism

Kéïta, L., Mottron, L., Dawson, M., & Bertone, A. (2011). Atypical Lateral Connectivity: A Neural Basis for Altered Visuospatial Processing in Autism. Biological Psychiatry, 70(9), 806-811. https://doi.org/10.1016/j.biopsych.2011.07.031

Date de publication: 10/09/2011 Ajout dans AutiHub: 03/07/2026 Type: Article Langue de l’article: Anglais

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Auteurs

Auteur·ices des publications
4
Auteur·ices de la publication identifié·es comme autistes
1 / 4 (25,0 %)

Résumé

CONTEXTE : La perception autistique comprend a la fois des performances inferieures et superieures dans differents types de taches visuospatiales. Des modeles neurocognitifs influents pertinents pour la perception atypique (c'est-a-dire, faible coherence centrale, fonctionnement perceptif ameliore) peuvent, a des degres divers, rendre compte de ces resultats. Cependant, les fondements neuronaux qui medient la perception visuospatiale autistique atypique restent a elucider. METHODES : Dans la presente etude, nous avons utilise un paradigme de masquage lateral pour evaluer l'integrite fonctionnelle des interactions laterales mediant le traitement de l'information visuospatiale dans les aires visuelles precoces chez des observateurs autistiques (n = 18) et non autistiques (n = 15). Les seuils de detection ont ete mesures pour des cibles de Gabor presentees centralement, flanquees de maniere colineaire a differentes distances (experience 1) et flanquees orthogonalement a differents contrastes (experience 2). RESULTATS : Les groupes autistique et non autistique ont montre une sensibilite accrue a la cible lorsque la distance entre les cibles colineaires et les flanqueurs etait faible (3 lambda), mais non lorsqu'elle etait grande (6 lambda). Cependant, l'effet de facilitation a courte distance etait significativement plus important pour le groupe autistique. En outre, nous avons observe un effet du contraste specifique au groupe : dans le groupe autistique, la sensibilite a la cible etait amelioree par de faibles contrastes des flanqueurs correspondant a des differences de luminance de 5 % et de 10 %, tandis que, pour le groupe non autistique, cet effet ne survenait qu'a un contraste de 10 %. CONCLUSIONS : Ces resultats soutiennent l'idee que la perception visuospatiale atypique dans l'autisme pourrait provenir d'une connectivite laterale modifiee au sein des aires visuelles primaires, affectant differemment la perception aux niveaux les plus precoces de l'extraction des caracteristiques.

BACKGROUND: Autistic perception encompasses both inferior and superior performance on different types of visuospatial tasks. Influential neurocognitive models relevant to atypical perception (i.e., weak central coherence, enhanced perceptual functioning) can, to differing degrees, account for these findings. However, the neural underpinnings mediating atypical visuospatial autistic perception have yet to be elucidated. METHODS: In the present study, we used a lateral masking paradigm to assess the functional integrity of lateral interactions mediating visuospatial information processing within early visual areas of autistic (n = 18) and nonautistic (n = 15) observers. Detection thresholds were measured for centrally presented Gabor targets flanked collinearly at different distances (experiment 1) and flanked orthogonally at different contrasts (experiment 2). RESULTS: Autistic and nonautistic groups showed increased target sensitivity when the distance between collinear targets and flankers was small (3 lambda) but not large (6 lambda). However, the effect of small-distance facilitation was significantly greater for the autistic group. In addition, we observed a group-specific effect of contrast: in the autistic group, target sensitivity was enhanced by low flanker contrasts of both 5% and 10% luminance difference, whereas for the nonautistic group, this effect occurred at 10% contrast only. CONCLUSIONS: These findings support the idea that atypical visuospatial perception in autism may originate from altered lateral connectivity within primary visual areas, differentially affecting perception at the earliest levels of feature extraction.

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Vue d’ensemble de l’inclusion dans la bibliographie

Ces indicateurs décrivent la bibliographie citée importée pour cette publication. Les métriques de références citées utilisent le total des références citées comme dénominateur. Les métriques d’auteurices cité·es indiquent si elles utilisent toutes les occurrences d’auteurices cité·es ou seulement les occurrences rattachées à des auteurices déjà intégré·es à la base de données AutiHub. Ils utilisent les rattachements mis en cache entre les auteurices cité·es et les auteurices intégré·es à la base de données AutiHub. Dernier calcul : 16/08/2026 11:30.

Références citées
65
Nombre total de références citées intégrées pour cette publication.
Références citées avec un·e auteur·ice identifié·e comme autiste
3 / 65 (4,6 %)
Occurrences d’auteur·ices cité·es identifié·es comme autistes
3 / 226 (1,3 %)
Parmi les occurrences rattachées à des auteurices intégré·es à la base de données AutiHub : 3 / 48 (6,2 %). Auteurices cité·es distinct·es identifié·es comme autistes : 1 / 162 (0,6 %).
Occurrences citées rattachées à la base AutiHub
48 / 226 (21,2 %)
Auteurices cité·es distinct·es rattaché·es : 24 / 162 (14,8 %)
Occurrences rattachées, non identifiées comme autistes
45 / 48 (93,8 %)
Parmi les seules occurrences rattachées. Sur l’ensemble des occurrences d’auteurices cité·es : 45 / 226 (19,9 %). Auteurices cité·es distinct·es rattaché·es, non identifié·es comme autistes : 23 / 24 (95,8 %).
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