Connectivite laterale atypique : une base neuronale pour un traitement visuospatial modifie dans l'autisme
Titre original en anglais : Atypical Lateral Connectivity: A Neural Basis for Altered Visuospatial Processing in Autism
Kéïta, L., Mottron, L., Dawson, M., & Bertone, A. (2011). Atypical Lateral Connectivity: A Neural Basis for Altered Visuospatial Processing in Autism. Biological Psychiatry, 70(9), 806-811. https://doi.org/10.1016/j.biopsych.2011.07.031
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Résumé
CONTEXTE : La perception autistique comprend a la fois des performances inferieures et superieures dans differents types de taches visuospatiales. Des modeles neurocognitifs influents pertinents pour la perception atypique (c'est-a-dire, faible coherence centrale, fonctionnement perceptif ameliore) peuvent, a des degres divers, rendre compte de ces resultats. Cependant, les fondements neuronaux qui medient la perception visuospatiale autistique atypique restent a elucider. METHODES : Dans la presente etude, nous avons utilise un paradigme de masquage lateral pour evaluer l'integrite fonctionnelle des interactions laterales mediant le traitement de l'information visuospatiale dans les aires visuelles precoces chez des observateurs autistiques (n = 18) et non autistiques (n = 15). Les seuils de detection ont ete mesures pour des cibles de Gabor presentees centralement, flanquees de maniere colineaire a differentes distances (experience 1) et flanquees orthogonalement a differents contrastes (experience 2). RESULTATS : Les groupes autistique et non autistique ont montre une sensibilite accrue a la cible lorsque la distance entre les cibles colineaires et les flanqueurs etait faible (3 lambda), mais non lorsqu'elle etait grande (6 lambda). Cependant, l'effet de facilitation a courte distance etait significativement plus important pour le groupe autistique. En outre, nous avons observe un effet du contraste specifique au groupe : dans le groupe autistique, la sensibilite a la cible etait amelioree par de faibles contrastes des flanqueurs correspondant a des differences de luminance de 5 % et de 10 %, tandis que, pour le groupe non autistique, cet effet ne survenait qu'a un contraste de 10 %. CONCLUSIONS : Ces resultats soutiennent l'idee que la perception visuospatiale atypique dans l'autisme pourrait provenir d'une connectivite laterale modifiee au sein des aires visuelles primaires, affectant differemment la perception aux niveaux les plus precoces de l'extraction des caracteristiques.
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