A model linking emotional dysregulation in neurodivergent people to the proprioceptive impact of joint hypermobility

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Eccles, J. A., Quadt, L., Garfinkel, S. N., & Critchley, H. D. (2024). A model linking emotional dysregulation in neurodivergent people to the proprioceptive impact of joint hypermobility. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1908), 20230247-20230247. https://doi.org/10.1098/rstb.2023.0247

Journal or book title
Philosophical Transactions of the Royal Society B Biological Sciences
Publisher
The Royal Society
Volume
379
Issue
1908
Pages
20230247-20230247
Article number
20230247
Publication date: 15 Jul 2024 Added to AutiHub: 25 Sep 2026 Type: Article Article language: English
Publisher source (DOI) Full text OpenAlex source

This publication is integrated into AutiHub through:

Authors

Publication authors
4
Publication authors identified as autistic
1 / 4 (25.0%)
  1. Jessica A. Eccles
  2. Lisa Quadt *
  3. Sarah N. Garfinkel
  4. Hugo D. Critchley

Abstract

Emotional feelings are putatively ascribed to central representation of bodily states in the context of expectation and uncertainty in both internal state and external world. Neurodivergent people are more likely to experience co-occurring mental health challenges, although mechanistic insights underpinning this association are scarce. We therefore undertook a study to test whether imprecise processing of proprioceptive error signals may underlie the connection between neurodivergence and emotional dysregulation. In a cohort of people with complex chronic conditions, including chronic pain/fatigue, and complex trauma, and in a comparison group, we assessed presence of neurodivergence, variant connective tissue manifested through joint hypermobility, and emotional dysregulation. We present a data-informed conceptual model showing that variant connective tissue determines whether proprioceptive surprise is linked with emotional dysregulation in neurodivergent individuals. We suggest that future research in this area may have important clinical implications for the interaction of mental and physical wellbeing in neurodivergent people. This article is part of the theme issue ‘Sensing and feeling: an integrative approach to sensory processing and emotional experience’.

Bibliography cited by this reference

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Cited bibliography overview

These indicators describe the bibliography cited by this publication. An author name is counted each time it appears in one cited reference, so the same person can be counted more than once. Names not yet linked to an author already present in AutiHub are treated as unknown, not as non-autistic. Last computed: 3 Oct 2026 08:20.

Cited references
50
With a DOI
46
Without a DOI, from raw bibliography text
3
10 / 50 (20.0%) cited references include at least one author identified as autistic.
References with data to complete
0 / 50 (0.0%)
References with detected author names
50 / 50 (100.0%)
Without detected author names
0
Without a structured title
0
Without a stable identifier
1
References with raw author names still to review
0
References with external metadata lookup issues
0
These indicators apply to cited references displayed on this page, after technical duplicates have been merged. A reference without a DOI can still support author statistics when a title and author names are available.
Author names detected in the cited bibliography
391
From DOI or external metadata
391
From validated raw bibliography text
0
Raw names already validated
0
Raw names still to review
0
118 / 391 (30.2%) names are linked to an author already present in AutiHub. 273 / 391 (69.8%) names are not yet linked.
Names linked to a person identified as autistic
23 / 391 (5.9%)
Calculated across all author names detected in the cited bibliography. Among names linked to an author already present in AutiHub: 23 / 118 (19.5%). Distinct people identified as autistic: 14 / 336 (4.2%).
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