Neurodivergence probable et tissu conjonctif variant chez des patients souffrant de douleur chronique/fatigue chronique : une étude cas-témoins

Titre original en anglais : Likely neurodivergence and variant connective tissue in patients with chronic pain/chronic fatigue: a case-control study

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Quadt, L., Savage, G., Bond, R., Davies, K. A., Critchley, H. D., & Eccles, J. A. (2026). Likely neurodivergence and variant connective tissue in patients with chronic pain/chronic fatigue: a case-control study. Journal of Psychiatric Research, 197, 125-132. https://doi.org/10.1016/j.jpsychires.2026.02.036

Date de publication: 18/02/2026 Ajout dans AutiHub: 25/09/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
6
Auteur·ices de la publication identifié·es comme autistes
1 / 6 (16,7 %)
  1. Lisa Quadt *
  2. Georgia Savage
  3. Rod Bond
  1. Kevin A Davies
  2. Hugo D. Critchley
  3. Jessica A. Eccles

Résumé

Les traits neurodivergents sont fréquemment observés chez les personnes souffrant de douleur chronique et/ou de fatigue chronique (CP/CF), mais les mécanismes sous-jacents restent incertains. Cette étude a examiné la proportion d'autisme probable et de trouble du déficit de l'attention avec hyperactivité (ADHD) chez les patients atteints de CP/CF et a évalué si l'hypermobilité articulaire, un marqueur de tissu conjonctif variant, médiatisait cette relation. Nous avons mené une étude cas-témoins au moyen d'une enquête en ligne. Quatre-vingt-trois adultes atteints de CP/CF et 91 adultes issus d'un groupe de comparaison non clinique ont rempli des mesures de dépistage validées de l'autisme, de l'ADHD et de l'hypermobilité articulaire. Les rapports de cotes (OR) et les intervalles de confiance (IC) à 95 % pour la neurodivergence probable ont été calculés à l'aide d'une régression logistique binaire. Une analyse de médiation a évalué si l'hypermobilité articulaire expliquait l'association entre la neurodivergence probable et la CP/CF. Les participants atteints de CP/CF présentaient des probabilités nettement plus élevées d'autisme probable (OR ajusté 14,3 ; IC à 95 % [6,5, 31,5]) et d'ADHD probable (OR ajusté 12,9 ; IC à 95 % [5,0, 26,7]) que le groupe de comparaison. La présence d'hypermobilité articulaire a significativement médiatisé la relation entre les traits neurodivergents et la CP/CF (effet indirect : b = 1,6 ; IC à 95 % [1,2, 2,1]). Nos résultats révèlent un schéma transdiagnostique d'une grande importance clinique. Chez les patients atteints de CP/CF, un dépistage systématique de la neurodivergence devrait être envisagé afin d'optimiser un accès équitable à un soutien approprié pour améliorer la qualité de vie.

Neurodivergent traits are frequently observed in individuals with chronic pain and/or chronic fatigue (CP/CF), yet the underlying mechanisms remain unclear. This study investigated the proportion of likely autism and attention deficit hyperactivity disorder (ADHD) in patients with CP/CF and examined whether joint hypermobility-a marker of variant connective tissue-mediated this relationship. We conducted a case-control study using an online survey. Eighty-three adults with CP/CF and 91 adults from a non-clinical comparison group completed validated screening measures for autism, ADHD, and joint hypermobility. Odds ratios (ORs) and 95% confidence intervals (CIs) for likely neurodivergence were calculated using binary logistic regression. Mediation analysis tested whether joint hypermobility explained the association between likely neurodivergence and CP/CF. Participants with CP/CF had markedly higher odds of likely autism (adjusted OR 14.3 95% CI [6.5, 31.5]) and likely ADHD (adjusted OR 12.9 95% CI [5.0, 26.7]) than the comparison group. The presence of joint hypermobility significantly mediated the relationship between neurodivergent traits and CP/CF (indirect effect: b = 1.6 95% CI [1.2, 2.1]). Our findings reveal a trans-diagnostic pattern of major clinical importance. In patients with CP/CF, routine screening for neurodivergence should be considered to optimise fair access to appropriate support for improved quality of life.

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Vue d’ensemble de la bibliographie citée

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Références citées
84
Avec un DOI
67
Sans DOI, à partir du texte brut de la bibliographie
17
11 / 84 (13,1 %) références citées comprennent au moins une personne identifiée comme autiste.
Références avec données à compléter
4 / 84 (4,8 %)
Références avec noms d’auteurices détectés
82 / 84 (97,6 %)
Sans nom d’auteurice détecté
2
Sans titre structuré
2
Sans identifiant stable
17
Références avec noms bruts d’auteurices restant à vérifier
0
Références avec problème de récupération des métadonnées externes
0
Ces indicateurs portent sur les références citées affichées sur cette page, après fusion des doublons techniques. Une référence sans DOI peut quand même soutenir les statistiques d’auteurices lorsqu’un titre et des noms d’auteurices sont disponibles.
Noms d’auteurices détectés dans la bibliographie citée
468
À partir du DOI ou de métadonnées externes
468
À partir du texte brut validé de la bibliographie
0
Noms bruts déjà validés
0
Noms bruts restant à vérifier
0
113 / 468 (24,1 %) noms sont associés à un·e auteurice déjà présent·e dans AutiHub. 355 / 468 (75,9 %) noms ne sont pas encore associés.
Noms associés à une personne identifiée comme autiste
16 / 468 (3,4 %)
Calculé sur l’ensemble des noms d’auteurices détectés dans la bibliographie citée. Parmi les noms associés à un·e auteurice déjà présent·e dans AutiHub : 16 / 113 (14,2 %). Personnes distinctes identifiées comme autistes : 7 / 393 (1,8 %).
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