Allèle APOE ε4 chez des adultes autistes d'âge moyen et plus âgés : associations avec l'apprentissage verbal et la mémoire

Titre original en anglais : APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory

Cette publication est incluse dans le projet « Contributions académiques de personnes autistes sur l’autisme ». un auteur·ice de cette publication est identifié·e comme autiste dans le projet.

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Harker, S. A., Al-Hassan, L., Huentelman, M. J., Braden, B. B., & Lewis, C. R. (2023). APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory. International Journal of Molecular Sciences, 24(21), 15988. https://doi.org/10.3390/ijms242115988

Publication date: 05/11/2023 Ajout dans AutiHub: 14/09/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
5
Auteur·ices de la publication identifié·es comme autistes
1 / 5 (20,0 %)
  1. Samantha A. Harker *
  2. Lamees Al-Hassan
  3. Matthew J. Huentelman
  4. B. Blair Braden
  5. Candace R. Lewis

Résumé

Le trouble du spectre de l'autisme (TSA) est un handicap neurodéveloppemental, et des données récentes suggèrent que les adultes autistes sont plus susceptibles de développer la maladie d'Alzheimer (Alz) et d'autres démences que les adultes neurotypiques (NT). L'allèle ε4 du gène de l'apolipoprotéine E (APOE) est le facteur de risque génétique le plus important pour la maladie d'Alzheimer et affecte négativement la cognition chez les adultes d'âge moyen et plus âgés (MA+). Cette étude visait à déterminer l'impact de l'allèle APOE ε4 sur l'apprentissage verbal et la mémoire chez des adultes autistes MA+ (âgés de 40 à 71 ans), par comparaison avec des adultes NT appariés. À l'aide du test d'apprentissage verbal auditif (AVLT), nous avons constaté que les porteurs de ε4 obtenaient de moins bons résultats en mémoire à court terme et en apprentissage verbal dans les groupes diagnostiques, mais qu'il n'y avait pas d'interaction avec le diagnostic. Dans des analyses exploratoires au sein des groupes de sexe et de diagnostic, seuls les hommes autistes porteurs d'APOE ε4 présentaient un moins bon apprentissage verbal (p = 0,02), par rapport aux hommes autistes non porteurs. Enfin, l'allèle APOE ε4 n'a pas affecté significativement la mémoire à long terme dans cet échantillon. Ces résultats reproduisent des travaux antérieurs indiquant que l'allèle APOE ε4 affecte négativement la mémoire à court terme et l'apprentissage verbal chez les adultes MA+, et présentent de nouvelles constatations préliminaires selon lesquelles les hommes autistes MA+ pourraient être vulnérables aux effets d'APOE ε4 sur l'apprentissage verbal. De futurs travaux avec un échantillon plus large sont nécessaires pour déterminer si les femmes autistes pourraient également être vulnérables.

Autism spectrum disorder (ASD) is a neurodevelopmental disability and recent evidence suggests that autistic adults are more likely to develop Alzheimer’s disease (Alz) and other dementias compared to neurotypical (NT) adults. The ε4-allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alz and negatively impacts cognition in middle-aged and older (MA+) adults. This study aimed to determine the impact of the APOE ε4-allele on verbal learning and memory in MA+ autistic adults (ages 40–71 years) compared to matched NT adults. Using the Auditory Verbal Learning Test (AVLT), we found that ε4 carriers performed worse on short-term memory and verbal learning across diagnosis groups, but there was no interaction with diagnosis. In exploratory analyses within sex and diagnosis groups, only autistic men carrying APOE ε4 showed worse verbal learning (p = 0.02), compared to autistic men who were not carriers. Finally, the APOE ε4-allele did not significantly affect long-term memory in this sample. These findings replicate previous work indicating that the APOE ε4-allele negatively impacts short-term memory and verbal learning in MA+ adults and presents new preliminary findings that MA+ autistic men may be vulnerable to the effects of APOE ε4 on verbal learning. Future work with a larger sample is needed to determine if autistic women may also be vulnerable.

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Références citées
62
Avec un DOI
56
Sans DOI, à partir du texte brut de la bibliographie
5
0 / 62 (0,0 %) références citées comprennent au moins une personne identifiée comme autiste.
Références avec données à compléter
4 / 62 (6,5 %)
Références avec noms d’auteurices détectés
58 / 62 (93,5 %)
Sans nom d’auteurice détecté
4
Sans titre structuré
4
Sans identifiant stable
4
Références avec noms bruts d’auteurices restant à vérifier
4
Références avec problème de récupération des métadonnées externes
0
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Noms d’auteurices détectés dans la bibliographie citée
679
À partir du DOI ou de métadonnées externes
679
À partir du texte brut validé de la bibliographie
0
Noms bruts déjà validés
0
Noms bruts restant à vérifier
8
56 / 679 (8,2 %) noms sont associés à un·e auteurice déjà présent·e dans AutiHub. 623 / 679 (91,8 %) noms ne sont pas encore associés.
Noms associés à une personne identifiée comme autiste
0 / 679 (0,0 %)
Calculé sur l’ensemble des noms d’auteurices détectés dans la bibliographie citée. Parmi les noms associés à un·e auteurice déjà présent·e dans AutiHub : 0 / 56 (0,0 %). Personnes distinctes identifiées comme autistes : 0 / 599 (0,0 %).
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