L'antagonisme beta-adrenergique module la connectivite fonctionnelle dans le reseau du mode par defaut chez des individus avec et sans trouble du spectre de l'autisme

Titre original en anglais : Beta-adrenergic antagonism modulates functional connectivity in the default mode network of individuals with and without autism spectrum disorder

Cette publication est incluse dans le projet « Contributions académiques de personnes autistes sur l’autisme ». un auteur·ice de cette publication est identifié·e comme autiste dans le projet.

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Hegarty, J. P., Ferguson, B. J., Zamzow, R. M., Rohowetz, L. J., Johnson, J. D., Christ, S. E., & Beversdorf, D. Q. (2016). Beta-adrenergic antagonism modulates functional connectivity in the default mode network of individuals with and without autism spectrum disorder. Brain Imaging and Behavior, 11(5), 1278-1289. https://doi.org/10.1007/s11682-016-9604-8

Date de publication: 06/10/2016 Ajout dans AutiHub: 05/10/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
7
Auteur·ices de la publication identifié·es comme autistes
1 / 7 (14,3 %)
  1. John P. Hegarty *
  2. Bradley J Ferguson
  3. Rachel M Zamzow
  4. Landon J. Rohowetz
  1. Jeffrey D Johnson
  2. Shawn E Christ
  3. David Quentin Beversdorf

Résumé

L'antagoniste beta-adrenergique propranolol est benefique pour certains domaines sociaux et de communication atteints dans le trouble du spectre de l'autisme (TSA), et ces benefices semblent etre associes a une connectivite fonctionnelle (CF) accrue dans le cerveau pendant l'execution de taches. La CF est impliquee dans le TSA, la majorite des etudes suggerant une hypoconnectivite a longue distance combinee a une hyperconnectivite locale specifique a certaines regions. L'objectif de la presente investigation etait d'examiner l'effet du propranolol sur la CF au repos et de determiner s'il existe des effets specifiques au TSA. Des participants avec et sans TSA ont assiste a trois seances au cours desquelles du propranolol, du nadolol (un antagoniste beta-adrenergique qui ne traverse pas la barriere hemato-encephalique) ou un placebo etaient administres. Des donnees d'IRMf a l'etat de repos ont ete acquises, et des techniques de theorie des graphes ont ete utilisees pour evaluer des aspects supplementaires de la CF. Par rapport au placebo, l'administration de propranolol etait associee a une diminution de la CF dans le sous-reseau prefrontal medial dorsal du reseau du mode par defaut et a une augmentation de la CF dans le sous-reseau du lobe temporal medial, independamment du diagnostic. Ces effets n'ont pas ete observes avec le nadolol, ce qui suggere que les alterations de la CF apres l'administration de propranolol n'etaient pas exclusivement dues a des effets cardiovasculaires peripheriques. Ainsi, l'antagonisme beta-adrenergique peut reguler a la hausse ou a la baisse la CF, selon le reseau, et modifier l'activation fonctionnelle coordonnee dans le cerveau. Ces changements du traitement de l'information, tels que mis en evidence par la CF, pourraient medier certains des effets cliniques et comportementaux de l'antagonisme beta-adrenergique precedemment rapportes chez des patients atteints de TSA.

The beta-adrenergic antagonist propranolol benefits some social and communication domains affected in autism spectrum disorder (ASD), and these benefits appear to be associated with increased functional connectivity (FC) in the brain during task performance. FC is implicated in ASD, with the majority of studies suggesting long distance hypo-connectivity combined with regionally specific local hyper-connectivity. The objective in the current investigation was to examine the effect of propranolol on FC at rest and determine whether ASD-specific effects exist. Participants with and without ASD attended three sessions in which propranolol, nadolol (a beta-adrenergic antagonist that does not cross the blood-brain barrier), or placebo were administered. Resting-state fMRI data were acquired, and graph theory techniques were utilized to assess additional aspects of FC. Compared to placebo, propranolol administration was associated with decreased FC in the dorsal medial prefrontal cortex subnetwork of the default mode network and increased FC in the medial temporal lobe subnetwork, regardless of diagnosis. These effects were not seen with nadolol suggesting that the alterations in FC following propranolol administration were not exclusively due to peripheral cardiovascular effects. Thus, beta-adrenergic antagonism can up- or down- regulate FC, depending on the network, and alter coordinated functional activation in the brain. These changes in information processing, as demonstrated by FC, may mediate some of the clinical and behavioral effects of beta-adrenergic antagonism previously reported in patients with ASD.

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Références citées
84
Avec un DOI
75
Sans DOI, à partir du texte brut de la bibliographie
9
0 / 84 (0,0 %) références citées comprennent au moins une personne identifiée comme autiste.
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83 / 84 (98,8 %)
Sans nom d’auteurice détecté
1
Sans titre structuré
5
Sans identifiant stable
9
Références avec noms bruts d’auteurices restant à vérifier
1
Références avec problème de récupération des métadonnées externes
0
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Noms d’auteurices détectés dans la bibliographie citée
392
À partir du DOI ou de métadonnées externes
392
À partir du texte brut validé de la bibliographie
0
Noms bruts déjà validés
0
Noms bruts restant à vérifier
1
55 / 392 (14,0 %) noms sont associés à un·e auteurice déjà présent·e dans AutiHub. 337 / 392 (86,0 %) noms ne sont pas encore associés.
Noms associés à une personne identifiée comme autiste
0 / 392 (0,0 %)
Calculé sur l’ensemble des noms d’auteurices détectés dans la bibliographie citée. Parmi les noms associés à un·e auteurice déjà présent·e dans AutiHub : 0 / 55 (0,0 %). Personnes distinctes identifiées comme autistes : 0 / 342 (0,0 %).
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