Beta-adrenergic antagonism modulates functional connectivity in the default mode network of individuals with and without autism spectrum disorder

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Hegarty, J. P., Ferguson, B. J., Zamzow, R. M., Rohowetz, L. J., Johnson, J. D., Christ, S. E., & Beversdorf, D. Q. (2016). Beta-adrenergic antagonism modulates functional connectivity in the default mode network of individuals with and without autism spectrum disorder. Brain Imaging and Behavior, 11(5), 1278-1289. https://doi.org/10.1007/s11682-016-9604-8

Publication date: 6 Oct 2016 Added to AutiHub: 5 Oct 2026 Type: Article Article language: English
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Authors

Publication authors
7
Publication authors identified as autistic
1 / 7 (14.3%)
  1. John P. Hegarty *
  2. Bradley J Ferguson
  3. Rachel M Zamzow
  4. Landon J. Rohowetz
  1. Jeffrey D Johnson
  2. Shawn E Christ
  3. David Quentin Beversdorf

Abstract

The beta-adrenergic antagonist propranolol benefits some social and communication domains affected in autism spectrum disorder (ASD), and these benefits appear to be associated with increased functional connectivity (FC) in the brain during task performance. FC is implicated in ASD, with the majority of studies suggesting long distance hypo-connectivity combined with regionally specific local hyper-connectivity. The objective in the current investigation was to examine the effect of propranolol on FC at rest and determine whether ASD-specific effects exist. Participants with and without ASD attended three sessions in which propranolol, nadolol (a beta-adrenergic antagonist that does not cross the blood-brain barrier), or placebo were administered. Resting-state fMRI data were acquired, and graph theory techniques were utilized to assess additional aspects of FC. Compared to placebo, propranolol administration was associated with decreased FC in the dorsal medial prefrontal cortex subnetwork of the default mode network and increased FC in the medial temporal lobe subnetwork, regardless of diagnosis. These effects were not seen with nadolol suggesting that the alterations in FC following propranolol administration were not exclusively due to peripheral cardiovascular effects. Thus, beta-adrenergic antagonism can up- or down- regulate FC, depending on the network, and alter coordinated functional activation in the brain. These changes in information processing, as demonstrated by FC, may mediate some of the clinical and behavioral effects of beta-adrenergic antagonism previously reported in patients with ASD.

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Cited references
84
With a DOI
75
Without a DOI, from raw bibliography text
9
0 / 84 (0.0%) cited references include at least one author identified as autistic.
References with data to complete
5 / 84 (6.0%)
References with detected author names
83 / 84 (98.8%)
Without detected author names
1
Without a structured title
5
Without a stable identifier
9
References with raw author names still to review
1
References with external metadata lookup issues
0
These indicators apply to cited references displayed on this page, after technical duplicates have been merged. A reference without a DOI can still support author statistics when a title and author names are available.
Author names detected in the cited bibliography
392
From DOI or external metadata
392
From validated raw bibliography text
0
Raw names already validated
0
Raw names still to review
1
55 / 392 (14.0%) names are linked to an author already present in AutiHub. 337 / 392 (86.0%) names are not yet linked.
Names linked to a person identified as autistic
0 / 392 (0.0%)
Calculated across all author names detected in the cited bibliography. Among names linked to an author already present in AutiHub: 0 / 55 (0.0%). Distinct people identified as autistic: 0 / 342 (0.0%).
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