Association entre dysfonctionnement glymphatique, eau libre, intégrité de la substance blanche et performance de mémoire à long terme chez des adultes autistes vieillissants

Titre original en anglais : Association of glymphatic dysfunction, free water, white matter integrity and long-term memory performance in aging autistic adults

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Zhang, Y., Ofori, E., Chen, K., Harker, S., Velez, M., Gallegos, S. M., Grabeel, K., Johnson, F., Baxter, L., Woodruff, B., & Braden, B. B. (2026). Association of glymphatic dysfunction, free water, white matter integrity and long-term memory performance in aging autistic adults. Molecular Autism, 17(1), 10-10. https://doi.org/10.1186/s13229-026-00705-4

Date de publication: 18/02/2026 Ajout dans AutiHub: 07/08/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
11
Auteur·ices de la publication identifié·es comme autistes
1 / 11 (9,1 %)
  1. Yuanchao Zhang
  2. Edward Ofori
  3. Kewei Chen
  4. Samantha Harker
  1. Manuela Velez
  2. Stephen M. Gallegos *
  3. Katie Grabeel
  4. Faith Johnson
  1. Leslie Baxter
  2. Bryan Woodruff
  3. B. Blair Braden

Résumé

CONTEXTE : Les adultes autistes présentent un risque accru de vieillissement cognitif accéléré et de maladie d'Alzheimer et démences apparentées (ADRD), mais les mécanismes neurobiologiques sous-jacents restent mal compris. Un dysfonctionnement du système glymphatique, un réseau à l'échelle du cerveau responsable de l'élimination des déchets via le flux de liquide interstitiel, peut contribuer à cette vulnérabilité en favorisant l'accumulation d'eau libre extracellulaire (FW) et la dégénérescence de la substance blanche (WM). METHODES : Au total, 113 adultes autistes et 90 adultes neurotypiques (NT) appariés selon l'âge et le sexe, âgés de 18 à 71 ans, ont subi une IRM multimodale et des évaluations de la mémoire épisodique. L'indice d'analyse d'images du tenseur de diffusion le long de l'espace périvasculaire (DTI-ALPS), ainsi que des cartes de FW et des cartes d'anisotropie fractionnelle (FA), ont été calculés pour chaque participant. Des comparaisons entre groupes, des corrélations et des analyses de médiation ont été réalisées. RESULTATS : Comparativement aux adultes NT, les adultes autistes présentaient des valeurs de DTI-ALPS significativement plus faibles, une FW du fornix plus élevée, une FA du fornix plus faible et des scores de mémoire épisodique plus faibles. L'accumulation de FW hippocampique liée à l'âge était plus prononcée chez les adultes autistes. Les analyses de médiation ont révélé que la FW du fornix médiatisait la relation entre DTI-ALPS et à la fois la FA du fornix et la FW hippocampique. Les scores de mémoire épisodique à long terme étaient corrélés à la FA du fornix, ainsi qu'à la FW de la substance grise de l'ensemble du cerveau et à la FA de la WM chez les adultes autistes. LIMITES : La conception transversale ne permet pas d'inférer une causalité concernant la fonction glymphatique, l'accumulation d'eau libre, l'intégrité de la WM et la cognition. De plus, notre échantillon n'était pas équilibré de manière uniforme selon le sexe et excluait les personnes présentant une déficience intellectuelle concomitante, ce qui peut limiter la généralisabilité à la population autiste plus large. CONCLUSIONS : Nos résultats suggèrent que le dysfonctionnement glymphatique et l'accumulation de FW peuvent contribuer à une microstructure anormale de la WM et à des difficultés de mémoire épisodique chez les adultes autistes sur une large tranche d'âge. Ces résultats indiquent des biomarqueurs potentiels pour identifier et intervenir dans le processus de vieillissement cognitif dans l'autisme.

BACKGROUND: Autistic adults are at elevated risk of accelerated cognitive aging and Alzheimer’s disease and related dementias (ADRD), yet the underlying neurobiological mechanisms remain poorly understood. Dysfunction in the glymphatic system—a brain-wide network responsible for clearing waste via interstitial fluid flow—may contribute to this vulnerability by promoting extracellular free water (FW) accumulation and white matter (WM) degeneration. METHODS: A total of 113 autistic and 90 age- and sex-matched neurotypical (NT) adults (aged 18–71 years) underwent multimodal MRI scanning and episodic memory assessments. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, alongside FW maps, and fractional anisotropy (FA) maps were computed for each participant. Group comparisons, correlations, and mediation analyses were performed. RESULTS: Autistic adults showed significantly lower DTI-ALPS values, higher fornix FW, lower fornix FA, and poorer episodic memory scores compared to NT adults. Age-related hippocampal FW accumulation was more pronounced in autistic adults. Mediation analyses revealed that fornix FW mediated the relationship between DTI-ALPS and both fornix FA and hippocampal FW. Long-term episodic memory scores correlated with fornix FA, as well as whole-brain gray matter FW and WM FA in autistic adults. LIMITATIONS: The cross-sectional design precludes causal inference regarding glymphatic function, free water accumulation, WM integrity, and cognition. In addition, our sample was not evenly balanced by sex and excluded individuals with co-occurring intellectual disability, which may limit generalizability to the broader autistic population. CONCLUSIONS: Our results suggest that glymphatic dysfunction and FW accumulation may contribute to aberrant WM microstructure and episodic memory challenges in autistic adults across a broad age range. These findings point to potential biomarkers for identifying and intervening in the cognitive aging process in autism.

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Ces indicateurs décrivent la bibliographie citée importée pour cette publication. Les métriques de références citées utilisent le total des références citées comme dénominateur. Les métriques d’auteurices cité·es indiquent si elles utilisent toutes les occurrences d’auteurices cité·es ou seulement les occurrences rattachées à des auteurices déjà intégré·es à la base de données AutiHub. Ils utilisent les rattachements mis en cache entre les auteurices cité·es et les auteurices intégré·es à la base de données AutiHub. Dernier calcul : 16/08/2026 11:31.

Références citées
62
Nombre total de références citées intégrées pour cette publication.
Références citées avec un·e auteur·ice identifié·e comme autiste
0 / 62 (0,0 %)
Occurrences d’auteur·ices cité·es identifié·es comme autistes
0 / 510 (0,0 %)
Parmi les occurrences rattachées à des auteurices intégré·es à la base de données AutiHub : 0 / 47 (0,0 %). Auteurices cité·es distinct·es identifié·es comme autistes : 0 / 445 (0,0 %).
Occurrences citées rattachées à la base AutiHub
47 / 510 (9,2 %)
Auteurices cité·es distinct·es rattaché·es : 32 / 445 (7,2 %)
Occurrences rattachées, non identifiées comme autistes
47 / 47 (100,0 %)
Parmi les seules occurrences rattachées. Sur l’ensemble des occurrences d’auteurices cité·es : 47 / 510 (9,2 %). Auteurices cité·es distinct·es rattaché·es, non identifié·es comme autistes : 32 / 32 (100,0 %).
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