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Amy Goodwin, Emily J. H. Jones, Simona Salomone, Luke Mason, Rebecca Holman, Jannath Begum-Ali, Anna Hunt, Martin Ruddock, et al.
(2021).
INTERSTAARS: Attention training for infants with elevated likelihood of developing ADHD: A proof-of-concept randomised controlled trial.
Translational Psychiatry, 11(1), 644.
Springer Science and Business Media LLC.
- Date de publication
-
20/12/2021
- Identifiant
-
10.1038/s41398-021-01698-9
- Auteurs
-
Amy Goodwin,
Emily J. H. Jones,
Simona Salomone,
Luke Mason,
Rebecca Holman,
Jannath Begum-Ali,
Anna Hunt,
Martin Ruddock,
George Vamvakas,
Emily Robinson,
Catherine J. Holden,
Chloë Taylor,
Tim J. Smith,
Edmund Sonuga-Barke,
Patrick Bolton,
Tony Charman,
Andrew Pickles,
Sam Wass,
Mark H. Johnson,
and the INTERSTAARS team
- Source
- Translational Psychiatry
- Détails
- 11(1), 644
- Type de référence
- article
- Éditeur
- Springer Science and Business Media LLC
- Source de métadonnées
- crossref
Résumé
Abstract Attention-deficit/hyperactivity disorder (ADHD) is first diagnosed during middle childhood, when patterns of difficulty are often established. Pre-emptive approaches that strengthen developing cognitive systems could offer an alternative to post-diagnostic interventions. This proof-of-concept randomised controlled trial (RCT) tested whether computerised gaze-based attention training is feasible and improves attention in infants liable to develop ADHD. Forty-three 9- to 16-month-old infants with a first-degree relative with ADHD were recruited (11/2015–11/2018) at two UK sites and randomised with minimisation by site and sex to receive 9 weekly sessions of either (a) gaze-contingent attention training (intervention; n = 20); or (b) infant-friendly passive viewing of videos (control, n = 23). Sessions were delivered at home with blinded outcome assessments. The primary outcome was a composite of attention measures jointly analysed via a multivariate ANCOVA with a combined effect size (ES) from coefficients at baseline, midpoint and endpoint (Registration: ISRCTN37683928 ). Uptake and compliance was good but intention-to-treat analysis showed no significant differences between 20 intervention and 23 control infants on primary (ES −0.4, 95% CI −0.9 to 0.2; Complier-Average-Causal Effect ES −0.6, 95% CI −1.6 to 0.5) or secondary outcomes (behavioural attention). There were no adverse effects on sleep but a small increase in post-intervention session fussiness. Although feasible, there was no support for short-term effects of gaze-based attention training on attention skills in early ADHD. Longer-term outcomes remain to be assessed. The study highlights challenges and opportunities for pre-emptive intervention approaches to the management of ADHD.
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