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Margaret H. Sibley, L. Eugene Arnold, James M. Swanson, Lily T. Hechtman, Traci M. Kennedy, Elizabeth Owens, Brooke S.G. Molina, Peter S. Jensen, et al. (2022). Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD. American Journal of Psychiatry, 179(2), 142-151. American Psychiatric Association Publishing.

Date de publication
février 2022
Identifiant
10.1176/appi.ajp.2021.21010032
Auteurs
Margaret H. Sibley, L. Eugene Arnold, James M. Swanson, Lily T. Hechtman, Traci M. Kennedy, Elizabeth Owens, Brooke S.G. Molina, Peter S. Jensen, Stephen P. Hinshaw, Arunima Roy, Andrea Chronis-Tuscano, Jeffrey H. Newcorn, Luis A. Rohde, for the MTA Cooperative Group
Source
American Journal of Psychiatry
Détails
179(2), 142-151
Type de référence
article
Éditeur
American Psychiatric Association Publishing
Source de métadonnées
crossref

Résumé

OBJECTIVE: It is estimated that childhood attention deficit hyperactivity disorder (ADHD) remits by adulthood in approximately 50% of cases; however, this conclusion is typically based on single endpoints, failing to consider longitudinal patterns of ADHD expression. The authors investigated the extent to which children with ADHD experience recovery and variable patterns of remission by adulthood. METHODS: Children with ADHD (N=558) in the Multimodal Treatment Study of ADHD (MTA) underwent eight assessments over follow-ups ranging from 2 years (mean age, 10.44 years) to 16 years (mean age, 25.12 years) after baseline. The authors identified participants with fully remitted, partially remitted, and persistent ADHD at each time point on the basis of parent, teacher, and self-reports of ADHD symptoms and impairment, treatment utilization, and substance use and mental disorders. Longitudinal patterns of remission and persistence were identified that considered context and timing. RESULTS: Approximately 30% of children with ADHD experienced full remission at some point during the follow-up period; however, a majority of them (60%) experienced recurrence of ADHD after the initial period of remission. Only 9.1% of the sample demonstrated recovery (sustained remission) by study endpoint, and only 10.8% demonstrated stable ADHD persistence across study time points. Most participants with ADHD (63.8%) had fluctuating periods of remission and recurrence over time. CONCLUSIONS: The MTA findings challenge the notion that approximately 50% of children with ADHD outgrow the disorder by adulthood. Most cases demonstrated fluctuating symptoms between childhood and young adulthood. Although intermittent periods of remission can be expected in most cases, 90% of children with ADHD in MTA continued to experience residual symptoms into young adulthood.

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