Billets de Michelle Dawson
Liens cités structurés
Miru Yun, Eunjoon Kim, Min Whan Jung (2021). Enhanced negative emotional processing limits behavioral flexibility in a mouse model of autism spectrum disorder. openRxiv.
Résumé
Abstract Impaired behavioral flexibility might underlie some of the symptoms associated with autism spectrum disorder (ASD). We investigated whether and how behavioral flexibility is impaired in a mouse model of ASD by testing Shank2 -knockout (Shank2 -KO) mice in reversal learning. Shank2 -KO mice were trained in probabilistic classical conditioning with two odor cues paired with water and air puff. Upon the reversal of cue-outcome contingency, Shank2 -KO mice were significantly slower than wild-type mice in reversing their anticipatory licking responses. Shank2 -KO mice also showed stronger anticipatory eye closure responses than wild-type mice to the air puff, raising a possibility that the impairment might be because of enhanced negative emotional processing. Indeed, Shank2- KO mice showed intact reversal learning when the strong air puff was replaced with a mild air puff. Shank2- KO mice also showed intact reversal learning between two odor cues predicting rewards with different probabilities. These results indicate that enhanced negative emotional processing suppresses reversal learning despite of intact capability to learn cue-outcome contingency changes in Shank2 -KO mice in our behavioral settings. Our findings suggest that behavioral flexibility may be seriously limited by abnormal emotional processing in ASD.
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