Transposable elements occur more frequently in autism-risk genes: Implications for the role of genomic instability in autism

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Williams, E., Casanova, M., Switala, A., Li, H., & Qiu, M. (2013). Transposable elements occur more frequently in autism-risk genes: Implications for the role of genomic instability in autism. Translational Neuroscience, 4(2), 172-202. https://doi.org/10.2478/s13380-013-0113-6

Publication date: 1 Jun 2013 Added to AutiHub: 14 Sep 2026 Type: Article Article language: English
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Authors

Publication authors
5
Publication authors identified as autistic
1 / 5 (20.0%)
  1. Emily Williams
  2. Manuel Casanova *
  3. Andrew Switala
  4. Hong Li
  5. Mengsheng Qiu

Abstract

Abstract An extremely large number of genes have been associated with autism. The functions of these genes span numerous domains and prove challenging in the search for commonalities underlying the conditions. In this study, we instead looked at characteristics of the genes themselves, specifically in the nature of their transposable element content. Utilizing available sequence databases, we compared occurrence of transposons in autismrisk genes to randomized controls and found that transposable content was significantly greater in our autism group. These results suggest a relationship between transposable element content and autism-risk genes and have implications for the stability of those genomic regions.

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Cited references
25
With a DOI
25
Without a DOI, from raw bibliography text
0
0 / 25 (0.0%) cited references include at least one author identified as autistic.
References with data to complete
1 / 25 (4.0%)
References with detected author names
24 / 25 (96.0%)
Without detected author names
1
Without a structured title
0
Without a stable identifier
0
References with raw author names still to review
0
References with external metadata lookup issues
0
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Author names detected in the cited bibliography
434
From DOI or external metadata
434
From validated raw bibliography text
0
Raw names already validated
0
Raw names still to review
0
31 / 434 (7.1%) names are linked to an author already present in AutiHub. 403 / 434 (92.9%) names are not yet linked.
Names linked to a person identified as autistic
0 / 434 (0.0%)
Calculated across all author names detected in the cited bibliography. Among names linked to an author already present in AutiHub: 0 / 31 (0.0%). Distinct people identified as autistic: 0 / 424 (0.0%).
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