Etude de cohorte comparant des femmes atteintes de trouble du spectre de l'autisme avec et sans hypermobilite articulaire generalisee

Titre original en anglais : A Cohort Study Comparing Women with Autism Spectrum Disorder with and without Generalized Joint Hypermobility

Cette publication est incluse dans le projet « Contributions académiques de personnes autistes sur l’autisme ». deux auteur·ices de cette publication sont identifié·es comme autistes dans le projet.

À propos de la mention auteur·ice autiste

Sources de métadonnées utilisées pour cette référence

OpenAlex Crossref OpenCitations
En savoir plus sur les sources utilisées

Casanova, M., Sharp, J. L., Edelson, S., Kelly, D., & Casanova, M. (2018). A Cohort Study Comparing Women with Autism Spectrum Disorder with and without Generalized Joint Hypermobility. Behavioral Sciences, 8(3), 35. https://doi.org/10.3390/bs8030035

Publication date: 17/03/2018 Ajout dans AutiHub: 14/09/2026 Type: Article Langue de l’article: Anglais
Source éditeur (DOI) Texte intégral Source OpenAlex

Cette publication est intégrée dans AutiHub via :

Auteurs

Auteur·ices des publications
5
Auteur·ices de la publication identifié·es comme autistes
2 / 5 (40,0 %)
  1. Manuel Casanova *
  2. Julia L. Sharp
  3. Stephen Edelson
  4. Desmond Kelly
  5. Manuel Casanova *

Résumé

Des rapports suggerent une comorbidite entre le trouble du spectre de l'autisme (TSA) et le trouble du tissu conjonctif, le syndrome d'Ehlers-Danlos (SED). Les personnes atteintes de SED et du spectre plus large de l'hypermobilite articulaire generalisee (HJG) presentent souvent des affections mediees par les systemes immunitaire et endocrinien. Par ailleurs, la deregulation immunitaire/endocrinienne est un theme populaire dans la recherche sur l'autisme. Nous avons interroge un groupe de femmes atteintes de TSA avec/sans HJG afin de determiner les differences dans les exophenotypes immunitaires/endocriniens. Les femmes atteintes de TSA agees de 25 ans ou plus ont ete invitees a participer a une enquete en ligne. Les participantes ont rempli un questionnaire concernant les diagnostics, les antecedents de symptomes immunitaires/endocriniens, les experiences de douleur et les antecedents de crises convulsives. Les femmes atteintes de TSA avec HJG (TSA/HJG) ont signale davantage d'affections mediees par les systemes immunitaire et endocrinien que leurs homologues sans HJG (p = 0.001). Les affections auto-immunes etaient particulierement importantes dans le groupe TSA/HJG (p = 0.027). La presence de symptomes a mediation immunitaire coexistait souvent avec d'autres symptomes de ce type (p < 0.001-0.020), de meme que les symptomes a mediation endocrine (p < 0.001-0.045), independamment du groupe. Enfin, le nombre de symptomes a mediation immunitaire et endocrine presentait une forte interrelation (p < 0.001), suggerant une interaction potentielle entre les systemes. Bien que nos resultats ne permettent pas d'estimer la comorbidite, ils renforcent les concepts d'une relation etiologique entre le TSA et l'HJG. Par ailleurs, les femmes atteintes de TSA/HJG presentent des exophenotypes immunitaires/endocriniens complexes par rapport a leurs homologues sans HJG. Nous examinons egalement comment le tissu conjonctif regule le systeme immunitaire et comment les systemes immunitaire/endocrinien peuvent a leur tour moduler la synthese du collagene, ce qui pourrait entrainer des taux plus eleves de HJG dans cette sous-population.

Reports suggest comorbidity between autism spectrum disorder (ASD) and the connective tissue disorder, Ehlers-Danlos syndrome (EDS). People with EDS and the broader spectrum of Generalized Joint Hypermobility (GJH) often present with immune- and endocrine-mediated conditions. Meanwhile, immune/endocrine dysregulation is a popular theme in autism research. We surveyed a group of ASD women with/without GJH to determine differences in immune/endocrine exophenotypes. ASD women 25 years or older were invited to participate in an online survey. Respondents completed a questionnaire concerning diagnoses, immune/endocrine symptom history, experiences with pain, and seizure history. ASD women with GJH (ASD/GJH) reported more immune- and endocrine-mediated conditions than their non-GJH counterparts (p = 0.001). Autoimmune conditions were especially prominent in the ASD/GJH group (p = 0.027). Presence of immune-mediated symptoms often co-occurred with one another (p < 0.001–0.020), as did endocrine-mediated symptoms (p < 0.001–0.045), irrespective of the group. Finally, the numbers of immune- and endocrine-mediated symptoms shared a strong inter-relationship (p < 0.001), suggesting potential system crosstalk. While our results cannot estimate comorbidity, they reinforce concepts of an etiological relationship between ASD and GJH. Meanwhile, women with ASD/GJH have complex immune/endocrine exophenotypes compared to their non-GJH counterparts. Further, we discuss how connective tissue regulates the immune system and how the immune/endocrine systems in turn may modulate collagen synthesis, potentially leading to higher rates of GJH in this subpopulation.

Bibliographie citée par cette référence

Les références citées sont importées depuis des sources externes de métadonnées lorsqu’elles sont disponibles. La liste peut être partielle.

Vue d’ensemble de la bibliographie citée

Ces indicateurs décrivent la bibliographie citée par cette publication. Un nom d’auteurice est compté chaque fois qu’il apparaît dans une référence citée : une même personne peut donc être comptée plusieurs fois. Les noms qui ne sont pas encore associés à un·e auteurice déjà présent·e dans AutiHub sont traités comme inconnus, pas comme non autistes. Dernier calcul : 14/09/2026 14:22.

Références citées
96
Avec un DOI
84
Sans DOI, à partir du texte brut de la bibliographie
11
0 / 96 (0,0 %) références citées comprennent au moins une personne identifiée comme autiste.
Références avec données à compléter
7 / 96 (7,3 %)
Références avec noms d’auteurices détectés
89 / 96 (92,7 %)
Sans nom d’auteurice détecté
7
Sans titre structuré
7
Sans identifiant stable
8
Références avec noms bruts d’auteurices restant à vérifier
7
Références avec problème de récupération des métadonnées externes
0
Ces indicateurs portent sur les références citées affichées sur cette page, après fusion des doublons techniques. Une référence sans DOI peut quand même soutenir les statistiques d’auteurices lorsqu’un titre et des noms d’auteurices sont disponibles.
Noms d’auteurices détectés dans la bibliographie citée
532
À partir du DOI ou de métadonnées externes
532
À partir du texte brut validé de la bibliographie
0
Noms bruts déjà validés
0
Noms bruts restant à vérifier
7
17 / 532 (3,2 %) noms sont associés à un·e auteurice déjà présent·e dans AutiHub. 515 / 532 (96,8 %) noms ne sont pas encore associés.
Noms associés à une personne identifiée comme autiste
0 / 532 (0,0 %)
Calculé sur l’ensemble des noms d’auteurices détectés dans la bibliographie citée. Parmi les noms associés à un·e auteurice déjà présent·e dans AutiHub : 0 / 17 (0,0 %). Personnes distinctes identifiées comme autistes : 0 / 498 (0,0 %).
  1. Tabassum Kotagasti (2015). Prevalence of different menstrual irregularities in women with abnormal uterine bleeding (AUB)—An observational study . Int. J. Curr. Res. Rev., 7(10), 66.
    Type: Article OpenAlex: https://openalex.org/W578858442
    Crossref OpenAlex
  2. Marco Castori , Brad Tinkle , Howard Levy , Rodney Grahame , Fransiska Malfait , Alan Hakim (2017). A framework for the classification of joint hypermobility and related conditions . American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 175(1), 148-157. Wiley.
    Type: Article DOI: 10.1002/ajmg.c.31539 OpenAlex: https://openalex.org/W2585695730
    Crossref OpenAlex OpenCitations
  3. Milo Careaga , Sally J. Rogers , Robin L. Hansen , David G. Amaral , Judy Van de Water , Paul Ashwood (2017). Immune Endophenotypes in Children With Autism Spectrum Disorder . Biological Psychiatry, 81(5), 434-441. Elsevier BV.
    Type: Article DOI: 10.1016/j.biopsych.2015.08.036 OpenAlex: https://openalex.org/W2127289457
    Crossref OpenAlex OpenCitations
  4. Vesa Kaartinen , David Warburton (2003). Fibrillin controls TGF-β activation . Nature Genetics, 33(3), 331-332. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/ng0303-331 OpenAlex: https://openalex.org/W1586552615
    Crossref OpenAlex OpenCitations
  5. Lorenzo Sinibaldi , Gianluca Ursini , Marco Castori (2015). Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers–Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised . American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 169(1), 97-106. Wiley.
    Type: Article DOI: 10.1002/ajmg.c.31430 OpenAlex: https://openalex.org/W2130560561
    Crossref OpenAlex OpenCitations
  6. Kyoko Okada , Kenji Hashimoto , Yasuhide Iwata , Kazuhiko Nakamura , Masatsugu Tsujii , Kenji J. Tsuchiya et al. (2007). Decreased serum levels of transforming growth factor-β1 in patients with autism . Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(1), 187-190. Elsevier BV.
    Type: Article DOI: 10.1016/j.pnpbp.2006.08.020 OpenAlex: https://openalex.org/W1982375486
    Crossref OpenAlex OpenCitations
  7. Bernard Y‐H. Thong , Teck‐Choon Tan (2011). Epidemiology and risk factors for drug allergy . British Journal of Clinical Pharmacology, 71(5), 684-700. Wiley.
    Type: Article DOI: 10.1111/j.1365-2125.2010.03774.x OpenAlex: https://openalex.org/W1765914614
    Crossref OpenAlex OpenCitations
  8. Mark A. Lumley , Margaret Jordan , Ralph Rubenstein , Petros Tsipouras , Mark I. Evans (1994). Psychosocial functioning in the Ehlers‐Danlos syndrome . American Journal of Medical Genetics, 53(2), 149-152. Wiley.
    Type: Article DOI: 10.1002/ajmg.1320530206 OpenAlex: https://openalex.org/W1992882474
    Crossref OpenAlex OpenCitations
  9. Anne M. Comi , Andrew W. Zimmerman , Virginia H. Frye , Paul A. Law , Joseph N. Peeden (1999). Familial Clustering of Autoimmune Disorders and Evaluation of Medical Risk Factors in Autism . Journal of Child Neurology, 14(6), 388-394. SAGE Publications.
    Type: Article DOI: 10.1177/088307389901400608 OpenAlex: https://openalex.org/W2034421798
    Crossref OpenAlex OpenCitations
  10. Kristen Lyall , Judy Van de Water , Paul Ashwood , Irva Hertz‐Picciotto (2015). Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study . Autism Research, 8(5), 567-574. Wiley.
    Type: Article DOI: 10.1002/aur.1471 OpenAlex: https://openalex.org/W1785717442
    Crossref OpenAlex OpenCitations
  11. Carolina Baeza-Velasco , Guillem Pailhez , Antonio Bulbena , Amaria Baghdadli (2015). Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry . General Hospital Psychiatry, 37(1), 24-30. Elsevier BV.
    Type: Article DOI: 10.1016/j.genhosppsych.2014.10.002 OpenAlex: https://openalex.org/W1991092640
    Crossref OpenAlex OpenCitations
  12. Kristen Lyall , Paul Ashwood , Judy Van de Water , Irva Hertz-Picciotto (2013). Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay . Journal of Autism and Developmental Disorders, 44(7), 1546. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-013-2017-2 OpenAlex: https://openalex.org/W2089727463
    Crossref OpenAlex OpenCitations
  13. Theoharis C. Theoharides (2009). Autism Spectrum Disorders and Mastocytosis . International Journal of Immunopathology and Pharmacology, 22(4), 859-865. SAGE Publications.
    Type: Article DOI: 10.1177/039463200902200401 OpenAlex: https://openalex.org/W1960998321
    Crossref OpenAlex OpenCitations
  14. Maya Shetreat-Klein , Shlomo Shinnar , Isabelle Rapin (2014). Abnormalities of joint mobility and gait in children with autism spectrum disorders . Brain and Development, 36(2), 91-96. Elsevier BV.
    Type: Article DOI: 10.1016/j.braindev.2012.02.005 OpenAlex: https://openalex.org/W2022782590
    Crossref OpenAlex OpenCitations
  15. Mirjam Urb , Donald C. Sheppard (2012). The Role of Mast Cells in the Defence against Pathogens . PLoS Pathogens, 8(4), e1002619. Public Library of Science (PLoS).
    Type: Article DOI: 10.1371/journal.ppat.1002619 OpenAlex: https://openalex.org/W2163303312
    Crossref OpenAlex OpenCitations
  16. DANIEL W. CRAMER , STACEY A. MISSMER (2002). The Epidemiology of Endometriosis . Annals of the New York Academy of Sciences, 955(1), 11-22. Wiley.
    Type: Article DOI: 10.1111/j.1749-6632.2002.tb02761.x OpenAlex: https://openalex.org/W1963892494
    Crossref OpenAlex OpenCitations
  17. Jessica Eccles , V. Iodice , N. Dowell , A. Owens , L. Hughes , S. Skipper et al. (2014). JOINT HYPERMOBILITY AND AUTONOMIC HYPERACTIVITY: RELEVANCE TO NEURODEVELOPMENTAL DISORDERS . Journal of Neurology, Neurosurgery & Psychiatry, 85(8), e3-e3. BMJ.
    Type: Article DOI: 10.1136/jnnp-2014-308883.9 OpenAlex: https://openalex.org/W1970207463
    Crossref OpenAlex OpenCitations
  18. Verónica Martínez‐Cerdeño , Stephen C. Noctor , Arnold R. Kriegstein (2006). Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex . European Journal of Neuroscience, 24(12), 3475-3488. Wiley.
    Type: Article DOI: 10.1111/j.1460-9568.2006.05239.x OpenAlex: https://openalex.org/W1970186168
    OpenAlex OpenCitations
  19. Gregory E. Demas , Shelley A. Adamo , Susannah S. French (2011). Neuroendocrine‐immune crosstalk in vertebrates and invertebrates: implications for host defence . Functional Ecology, 25(1), 29-39. Wiley.
    Type: Article DOI: 10.1111/j.1365-2435.2010.01738.x OpenAlex: https://openalex.org/W2096596075
    Crossref OpenAlex OpenCitations
  20. J. R. Hawse , M. Subramaniam , J. N. Ingle , M. J. Oursler , N. M. Rajamannan , T. C. Spelsberg (2008). Estrogen‐TGFβ cross‐talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors . Journal of Cellular Biochemistry, 103(2), 383-392. Wiley.
    Type: Article DOI: 10.1002/jcb.21425 OpenAlex: https://openalex.org/W2118099347
    Crossref OpenAlex OpenCitations
  21. Antonin Bukovsky (2006). Immune system involvement in the regulation of ovarian function and augmentation of cancer . Microscopy Research and Technique, 69(6), 482-500. Wiley.
    Type: Article DOI: 10.1002/jemt.20307 OpenAlex: https://openalex.org/W2112115327
    Crossref OpenAlex OpenCitations
  22. Anne M. Connolly , Michael Chez , Elizabeth M. Streif , Richard M. Keeling , Paul T. Golumbek , Jennifer M. Kwon et al. (2006). Brain-Derived Neurotrophic Factor and Autoantibodies to Neural Antigens in Sera of Children with Autistic Spectrum Disorders, Landau-Kleffner Syndrome, and Epilepsy . Biological Psychiatry, 59(4), 354-363. Elsevier BV.
    Type: Article DOI: 10.1016/j.biopsych.2005.07.004 OpenAlex: https://openalex.org/W2057999917
    Crossref OpenAlex OpenCitations
  23. DOROTHY I. SHULMAN , IVY MUHAR , E. VERENA JORGENSEN , FRANK B. DIAMOND , BARRY B. BERCU , ALLEN W. ROOT (1997). Autoimmune Hyperthyroidism in Prepubertal Children and Adolescents: Comparison of Clinical and Biochemical Features at Diagnosis and Responses to Medical Therapy . Thyroid, 7(5), 755-760. SAGE Publications.
    Type: Article DOI: 10.1089/thy.1997.7.755 OpenAlex: https://openalex.org/W1972764394
    Crossref OpenAlex OpenCitations
  24. Lauren Matelski , Judy Van de Water (2016). Risk factors in autism: Thinking outside the brain . Journal of Autoimmunity, 67, 1-7. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaut.2015.11.003 OpenAlex: https://openalex.org/W2216023838
    Crossref OpenAlex OpenCitations
  25. M D'Amelio , I Ricci , R Sacco , X Liu , L D'Agruma , L A Muscarella et al. (2005). Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene–environment interactions . Molecular Psychiatry, 10(11), 1006-1016. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/sj.mp.4001714 OpenAlex: https://openalex.org/W2068923820
    Crossref OpenAlex OpenCitations
  26. Ingrid Cheung , Peter Vadas (2015). A New Disease Cluster: Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome, and Ehlers-Danlos Syndrome . Journal of Allergy and Clinical Immunology, 135(2), AB65. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaci.2014.12.1146 OpenAlex: https://openalex.org/W1981165824
    Crossref OpenAlex OpenCitations
  27. Enid R. Neptune , Pamela A. Frischmeyer , Dan E. Arking , Loretha Myers , Tracie E. Bunton , Barbara Gayraud et al. (2003). Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome . Nature Genetics, 33(3), 407-411. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/ng1116 OpenAlex: https://openalex.org/W2122588714
    Crossref OpenAlex OpenCitations
  28. Erin Ingudomnukul , Simon Baron-Cohen , Sally Wheelwright , Rebecca Knickmeyer (2007). Elevated rates of testosterone-related disorders in women with autism spectrum conditions . Hormones and Behavior, 51(5), 597-604. Elsevier BV.
    Type: Article DOI: 10.1016/j.yhbeh.2007.02.001 OpenAlex: https://openalex.org/W2169036405
    Crossref OpenAlex OpenCitations
  29. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) . Human Reproduction, 19(1), 41-47. Oxford University Press (OUP).
    Type: Article DOI: 10.1016/j.fertnstert.2003.10.004 OpenAlex: https://openalex.org/W2186218348
    Crossref OpenAlex OpenCitations
  30. Raz Yirmiya , Inbal Goshen (2011). Immune modulation of learning, memory, neural plasticity and neurogenesis . Brain, Behavior, and Immunity, 25(2), 181-213. Elsevier BV.
    Type: Article DOI: 10.1016/j.bbi.2010.10.015 OpenAlex: https://openalex.org/W1989369404
    Crossref OpenAlex OpenCitations
  31. Guifeng Xu , Jin Jing , Katherine Bowers , Buyun Liu , Wei Bao (2014). Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis . Journal of Autism and Developmental Disorders, 44(4), 766-775. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-013-1928-2 OpenAlex: https://openalex.org/W2080896782
    Crossref OpenAlex OpenCitations
  32. J A Cairns , A F Walls (1997). Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. Journal of Clinical Investigation, 99(6), 1313-1321. American Society for Clinical Investigation.
    Type: Article DOI: 10.1172/jci119290 OpenAlex: https://openalex.org/W2010465872
    Crossref OpenAlex OpenCitations
  33. Paul Ashwood , Amanda Enstrom , Paula Krakowiak , Irva Hertz-Picciotto , Robin L. Hansen , Lisa A. Croen et al. (2008). Decreased transforming growth factor beta1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes . Journal of Neuroimmunology, 204(1-2), 149-153. Elsevier BV.
    Type: Article DOI: 10.1016/j.jneuroim.2008.07.006 OpenAlex: https://openalex.org/W1990577935
    Crossref OpenAlex OpenCitations
  34. Brian K. Lee , Stefan Arver , Linnea Widman , Renee M. Gardner , Cecilia Magnusson , Christina Dalman et al. (2017). Maternal hirsutism and autism spectrum disorders in offspring . Autism Research, 10(9), 1544-1546. Wiley.
    Type: Article DOI: 10.1002/aur.1797 OpenAlex: https://openalex.org/W2605244719
    Crossref OpenAlex OpenCitations
  35. Marco Castori , Silvia Morlino , Chiara Dordoni , Claudia Celletti , Filippo Camerota , Marco Ritelli et al. (2012). Gynecologic and obstetric implications of the joint hypermobility syndrome (a.k.a. Ehlers–Danlos syndrome hypermobility type) in 82 Italian patients . American Journal of Medical Genetics Part A, 158A(9), 2176-2182. Wiley.
    Type: Article DOI: 10.1002/ajmg.a.35506 OpenAlex: https://openalex.org/W2048227541
    Crossref OpenAlex OpenCitations
  36. Stefano Palomba , Rosa Marotta , Annalisa Di Cello , Tiziana Russo , Angela Falbo , Francesco Orio et al. (2012). Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case–control study . Clinical Endocrinology, 77(6), 898-904. Wiley.
    Type: Article DOI: 10.1111/j.1365-2265.2012.04443.x OpenAlex: https://openalex.org/W2086760234
    Crossref OpenAlex OpenCitations
  37. Mette Hansen , Mads Kongsgaard , Lars Holm , Dorthe Skovgaard , S. Peter Magnusson , Klaus Qvortrup et al. (2009). Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women . Journal of Applied Physiology, 106(4), 1385-1393. American Physiological Society.
    Type: Article DOI: 10.1152/japplphysiol.90935.2008 OpenAlex: https://openalex.org/W2119466011
    Crossref OpenAlex OpenCitations
  38. Elisabetta Polazzi , Ilaria Mengoni , Marco Caprini , Emiliano Peña-Altamira , Ewelina Kurtys , Barbara Monti (2013). Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity . Neurosignals, 21(1-2), 112-128. S. Karger AG.
    Type: Article DOI: 10.1159/000337115 OpenAlex: https://openalex.org/W1996024251
    OpenAlex
  39. Marco Castori , Filippo Camerota , Claudia Celletti , Paola Grammatico , Luca Padua (2010). Ehlers–Danlos syndrome hypermobility type and the excess of affected females: Possible mechanisms and perspectives . American Journal of Medical Genetics Part A, 152A(9), 2406-2408. Wiley.
    Type: Article DOI: 10.1002/ajmg.a.33585 OpenAlex: https://openalex.org/W1998906297
    Crossref OpenAlex OpenCitations
  40. K George MM Alberti , Paul Zimmet , Jonathan Shaw (2005). The metabolic syndrome—a new worldwide definition . The Lancet, 366(9491), 1059-1062. Elsevier BV.
    Type: Article DOI: 10.1016/s0140-6736(05)67402-8 OpenAlex: https://openalex.org/W2107732097
    Crossref OpenAlex OpenCitations
  41. Reena M. Talwar , Brendan S. Wong , Kathy Svoboda , Richard P. Harper (2006). Effects of Estrogen on Chondrocyte Proliferation and Collagen Synthesis in Skeletally Mature Articular Cartilage . Journal of Oral and Maxillofacial Surgery, 64(4), 600-609. Elsevier BV.
    Type: Article DOI: 10.1016/j.joms.2005.12.006 OpenAlex: https://openalex.org/W1997428566
    Crossref OpenAlex OpenCitations
  42. Lisa J. McIntosh , Veronica T. Mallett, , Jane D. Frahm , David A Richardson , Mark I. Evans, (1995). Gynecologic Disorders in Women With Ehlers-Danlos Syndrome . Journal of the Society for Gynecologic Investigation, 2(3), 559-564. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1177/107155769500200309 OpenAlex: https://openalex.org/W4251954864
    Crossref OpenAlex OpenCitations
  43. Martin Cederlöf , Henrik Larsson , Paul Lichtenstein , Catarina Almqvist , Eva Serlachius , Jonas F. Ludvigsson (2016). Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers–Danlos syndrome or hypermobility syndrome and their siblings . BMC Psychiatry, 16(1), 207-207. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/s12888-016-0922-6 OpenAlex: https://openalex.org/W2471836915
    Crossref OpenAlex OpenCitations
  44. Anne Zimmermann , David Bernuit , Christoph Gerlinger , Matthias Schaefers , Katharina Geppert (2012). Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women . BMC Women's Health, 12(1), 6-6. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/1472-6874-12-6 OpenAlex: https://openalex.org/W1998329793
    Crossref OpenAlex OpenCitations
  45. AJ Hakim , R Grahame (2003). A SIMPLE QUESTIONNAIRE TO DETECT HYPERMOBILITY: AN ADJUNCT TO THE ASSESSMENT OF PATIENTS WITH DIFFUSE MUSCULOSKELETAL PAIN . International Journal of Clinical Practice, 57(3), 163-166. Wiley.
    Type: Article DOI: 10.1111/j.1742-1241.2003.tb10455.x OpenAlex: https://openalex.org/W4367363134
    Crossref OpenAlex OpenCitations
  46. Lorenzo Monasta , Luca Ronfani , Federico Marchetti , Marcella Montico , Liza Vecchi Brumatti , Alessandro Bavcar et al. (2012). Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates . PLoS ONE, 7(4), e36226. Public Library of Science (PLoS).
    Type: Article DOI: 10.1371/journal.pone.0036226 OpenAlex: https://openalex.org/W2169729911
    Crossref OpenAlex OpenCitations
  47. DOROTHY H. HENNEMAN (1968). Effect of Estrogen on in Vivo and in Vitro Collagen Biosynthesis and Maturation in Old and Young Female Guinea Pigs 1 . Endocrinology, 83(4), 678-690. The Endocrine Society.
    Type: Article DOI: 10.1210/endo-83-4-678 OpenAlex: https://openalex.org/W2002801232
    Crossref OpenAlex OpenCitations
  48. Giovanni Murialdo , Flavia Magri , Gianluca Tamagno , Pietro Ameri , Antonella Camera , Silvia Colnaghi et al. (2009). Seizure frequency and sex steroids in women with partial epilepsy on antiepileptic therapy . Epilepsia, 50(8), 1920-1926. Wiley.
    Type: Article DOI: 10.1111/j.1528-1167.2009.02178.x OpenAlex: https://openalex.org/W2024247977
    Crossref OpenAlex OpenCitations
  49. Kerstin Felgentreff , Matthias Siepe , Stefan Kotthoff , Yskert von Kodolitsch , Kristina Schachtrup , Luigi D. Notarangelo et al. (2014). Severe eczema and Hyper-IgE in Loeys–Dietz-syndrome — Contribution to new findings of immune dysregulation in connective tissue disorders . Clinical Immunology, 150(1), 43-50. Elsevier BV.
    Type: Article DOI: 10.1016/j.clim.2013.11.008 OpenAlex: https://openalex.org/W2013003453
    Crossref OpenAlex OpenCitations
  50. D. W. Teele , J. O. Klein , B. Rosner , Greater Boston Otitis Media Study Group (1989). Epidemiology of Otitis Media During the First Seven Years of Life in Children in Greater Boston: A Prospective, Cohort Study . Journal of Infectious Diseases, 160(1), 83-94. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/infdis/160.1.83 OpenAlex: https://openalex.org/W2159189010
    Crossref OpenAlex OpenCitations
  51. D CHOI (1988). Glutamate neurotoxicity and diseases of the nervous system . Neuron, 1(8), 623-634. Elsevier BV.
    Type: Article DOI: 10.1016/0896-6273(88)90162-6 OpenAlex: https://openalex.org/W2016575029
    OpenAlex
  52. (s. d.). Asthma and Allergy Foundation of America (AAFA) (2017, May 23). Allergy Facts and Figures. Available online: http://www.aafa.org/page/allergy-facts.aspx .
    Type: Autre
    Crossref
  53. Pamela A. Frischmeyer-Guerrerio , Anthony L. Guerrerio , Gretchen Oswald , Kristin Chichester , Loretha Myers , Marc K. Halushka et al. (2013). TGFβ Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease . Science Translational Medicine, 5(195), 195ra94. American Association for the Advancement of Science (AAAS).
    Type: Article DOI: 10.1126/scitranslmed.3006448 OpenAlex: https://openalex.org/W2076245289
    Crossref OpenAlex OpenCitations
  54. Peter Matt , Florian Schoenhoff , Jennifer Habashi , Tammy Holm , Christel Van Erp , David Loch et al. (2009). Circulating Transforming Growth Factor-β in Marfan Syndrome . Circulation, 120(6), 526-532. Ovid Technologies (Wolters Kluwer Health).
    Type: Article DOI: 10.1161/circulationaha.108.841981 OpenAlex: https://openalex.org/W2018492695
    Crossref OpenAlex OpenCitations
  55. Lara J Akinbami , Jeanne E Moorman , Cathy Bailey , Hatice S Zahran , Michele King , Carol A Johnson et al. (2012). Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010 . NCHS Data Brief, 94(94), 1.
    Type: Article OpenAlex: https://openalex.org/W2185196942
    Crossref OpenAlex
  56. Glinda S. Cooper , Milele L.K. Bynum , Emily C. Somers (2009). Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases . Journal of Autoimmunity, 33(3-4), 197-207. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaut.2009.09.008 OpenAlex: https://openalex.org/W2078744808
    Crossref OpenAlex OpenCitations
  57. Tammy M. Holm , Jennifer P. Habashi , Jefferson J. Doyle , Djahida Bedja , YiChun Chen , Christel van Erp et al. (2011). Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice . Science, 332(6027), 358-361. American Association for the Advancement of Science (AAAS).
    Type: Article DOI: 10.1126/science.1192149 OpenAlex: https://openalex.org/W2023431960
    Crossref OpenAlex OpenCitations
  58. Mohamed Salem (2004). Estrogen, A Double-Edged Sword: Modulation of TH1- and TH2-Mediated Inflammations by Differential Regulation of TH1 / TH2 Cytokine Production . Current Drug Target -Inflammation & Allergy, 3(1), 97-104. Bentham Science Publishers Ltd..
    Type: Article DOI: 10.2174/1568010043483944 OpenAlex: https://openalex.org/W2030480043
    Crossref OpenAlex OpenCitations
  59. J.B. Shi , Q. L. Fu , H. Zhang , L. Cheng , Y. J. Wang , D. D. Zhu et al. (2015). Epidemiology of chronic rhinosinusitis: results from a cross‐sectional survey in seven C hinese cities . Allergy, 70(5), 533-539. Wiley.
    Type: Article DOI: 10.1111/all.12577 OpenAlex: https://openalex.org/W2059917187
    Crossref OpenAlex OpenCitations
  60. J.I. Silverberg , N.B. Silverberg (2014). Epidemiology and extracutaneous comorbidities of severe acne in adolescence: a U.S. population-based study . British Journal of Dermatology, 170(5), 1136-1142. Oxford University Press (OUP).
    Type: Article DOI: 10.1111/bjd.12912 OpenAlex: https://openalex.org/W2037872981
    Crossref OpenAlex OpenCitations
  61. Stanley M. Caress , Anne C. Steinemann (2004). Prevalence of Multiple Chemical Sensitivities: A Population-Based Study in the Southeastern United States . American Journal of Public Health, 94(5), 746-747. American Public Health Association.
    Type: Article DOI: 10.2105/ajph.94.5.746 OpenAlex: https://openalex.org/W2113753377
    Crossref OpenAlex OpenCitations
  62. Annamaria Vezzani , Daniela Moneta , Cristina Richichi , Marisa Aliprandi , Stephanie J. Burrows , Teresa Ravizza et al. (2002). Functional Role of Inflammatory Cytokines and Antiinflammatory Molecules in Seizures and Epileptogenesis . Epilepsia, 43(s5), 30-35. Wiley.
    Type: Article DOI: 10.1046/j.1528-1157.43.s.5.14.x OpenAlex: https://openalex.org/W2042829577
    Crossref OpenAlex OpenCitations
  63. Tobias Liebregts , Birgit Adam , Christoph Bredack , Alexander Röth , Susanne Heinzel , Sue Lester et al. (2007). Immune Activation in Patients With Irritable Bowel Syndrome . Gastroenterology, 132(3), 913-920. Elsevier BV.
    Type: Article DOI: 10.1053/j.gastro.2007.01.046 OpenAlex: https://openalex.org/W2114437230
    Crossref OpenAlex OpenCitations
  64. A De Paepe , F Malfait (2012). The Ehlers–Danlos syndrome, a disorder with many faces . Clinical Genetics, 82(1), 1-11. Wiley.
    Type: Article DOI: 10.1111/j.1399-0004.2012.01858.x OpenAlex: https://openalex.org/W2074619878
    Crossref OpenAlex OpenCitations
  65. Jonathan J. Lyons , Guangping Sun , Kelly D. Stone , Celeste Nelson , Laura Wisch , Michelle O'Brien et al. (2014). Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities . Journal of Allergy and Clinical Immunology, 133(5), 1471-1474. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaci.2013.11.039 OpenAlex: https://openalex.org/W2104298123
    Crossref OpenAlex OpenCitations
  66. I. Matalliotakis , H. Cakmak , M. Matalliotakis , D. Kappou , A. Arici (2012). High rate of allergies among women with endometriosis . Journal of Obstetrics and Gynaecology, 32(3), 291-293. Informa UK Limited.
    Type: Article DOI: 10.3109/01443615.2011.644358 OpenAlex: https://openalex.org/W2158556760
    Crossref OpenAlex OpenCitations
  67. Paul Claman (2004). Men at risk: occupation and male infertility . Fertility and Sterility, 81, 19-26. Elsevier BV.
    Type: Article DOI: 10.1016/s0015-0282(03)01188-9 OpenAlex: https://openalex.org/W2064315460
    OpenAlex
  68. N. Sinaii (2002). High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis . Human Reproduction, 17(10), 2715-2724. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/humrep/17.10.2715 OpenAlex: https://openalex.org/W2112255313
    Crossref OpenAlex OpenCitations
  69. Brian Hon‐Yin Chung , Stephen Tak‐Sum Lam , Tony Ming‐For Tong , Susanna Yuk‐Han Li , Kin‐Shing Lun , Daniel Hon‐Chuen Chan et al. (2009). Identification of novel FBN1 and TGFBR2 mutations in 65 probands with Marfan syndrome or Marfan‐like phenotypes . American Journal of Medical Genetics Part A, 149A(7), 1452-1459. Wiley.
    Type: Article DOI: 10.1002/ajmg.a.32918 OpenAlex: https://openalex.org/W2068786435
    Crossref OpenAlex OpenCitations
  70. Christin N. Collier , Julie C. Harper , Wendy C. Cantrell , Wenquan Wang , K. Wade Foster , Boni E. Elewski (2008). The prevalence of acne in adults 20 years and older . Journal of the American Academy of Dermatology, 58(1), 56-59. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaad.2007.06.045 OpenAlex: https://openalex.org/W2149521457
    Crossref OpenAlex OpenCitations
  71. M Cutolo , A Sulli , S Capellino , B Villaggio , P Montagna , B Seriolo et al. (2004). Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity . Lupus, 13(9), 635-638. SAGE Publications.
    Type: Article DOI: 10.1191/0961203304lu1094oa OpenAlex: https://openalex.org/W2107416858
    Crossref OpenAlex OpenCitations
  72. KIRSTINE MÜNSTER , PETER HELM , LONE SCHMIDT (1992). Secondary amenorrhoea: prevalence and medical contact—a cross–sectional study from a Danish county . BJOG: An International Journal of Obstetrics & Gynaecology, 99(5), 430-433. Wiley.
    Type: Article DOI: 10.1111/j.1471-0528.1992.tb13763.x OpenAlex: https://openalex.org/W2072554013
    Crossref OpenAlex OpenCitations
  73. Ali H. Mokdad , Earl S. Ford , Barbara A. Bowman , William H. Dietz , Frank Vinicor , Virginia S. Bales et al. (2003). Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001 . JAMA, 289(1), 76. American Medical Association (AMA).
    Type: Article DOI: 10.1001/jama.289.1.76 OpenAlex: https://openalex.org/W2168536185
    Crossref OpenAlex OpenCitations
  74. Kaoru Sato , Tatsuhiro Akaishi , Norio Matsuki , Yasuo Ohno , Ken Nakazawa (2007). β-Estradiol induces synaptogenesis in the hippocampus by enhancing brain-derived neurotrophic factor release from dentate gyrus granule cells . Brain Research, 1150, 108-120. Elsevier BV.
    Type: Article DOI: 10.1016/j.brainres.2007.02.093 OpenAlex: https://openalex.org/W2073998469
    Crossref OpenAlex OpenCitations
  75. Hong Ju , Mark Jones , Gita Mishra (2014). The Prevalence and Risk Factors of Dysmenorrhea . Epidemiologic Reviews, 36(1), 104-113. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/epirev/mxt009 OpenAlex: https://openalex.org/W2136737524
    Crossref OpenAlex OpenCitations
  76. Uriel Halbreich , Jeff Borenstein , Terry Pearlstein , Linda S Kahn (2003). The prevalence, impairment, impact, and burden of premenstrual dysphoric disorder (PMS/PMDD) . Psychoneuroendocrinology, 28, 1-23. Elsevier BV.
    Type: Article DOI: 10.1016/s0306-4530(03)00098-2 OpenAlex: https://openalex.org/W2098057713
    Crossref OpenAlex OpenCitations
  77. Ushma D Upadhyay , Elizabeth Needham Waddell , Stephanie Young , Bonnie D Kerker , Magdalena Berger , Thomas Matte et al. (2010). Prevalence, awareness, treatment, and control of high LDL cholesterol in New York City, 2004 . Prev. Chronic Dis., 7(3), A61.
    Type: Article OpenAlex: https://openalex.org/W2184905494
    Crossref OpenAlex
  78. H.F. Escobar-Morreale , E. Carmina , D. Dewailly , A. Gambineri , F. Kelestimur , P. Moghetti et al. (2012). Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society . Human Reproduction Update, 18(2), 146-170. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/humupd/dmr042 OpenAlex: https://openalex.org/W2119532054
    Crossref OpenAlex OpenCitations
  79. (s. d.). Centers for Disease Control and Prevention (CDC) (2017, July 05). Hypertension among Adults in the United States: National Health and Nutrition Examination Survey, 2011–2012, Available online: https://www.cdc.gov/nchs/products/databriefs/db133.htm .
    Type: Autre
    Crossref
  80. (s. d.). Centers for Disease Control and Prevention (CDC) (2017, July 05). Infertility FAQs, Available online: https://www.cdc.gov/reproductivehealth/infertility/ .
    Type: Autre
    Crossref
  81. Stacey E. Alexeeff , Vincent Yau , Yinge Qian , Meghan Davignon , Frances Lynch , Phillip Crawford et al. (2017). Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children . Journal of Autism and Developmental Disorders, 47(7), 2067-2079. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-017-3130-4 OpenAlex: https://openalex.org/W2607172469
    Crossref OpenAlex OpenCitations
  82. L McIntosh (1995). Gynecologic disorders in women with Ehlers-Danlos syndrome . Journal of the Society for Gynecologic Investigation, 2(3), 559-564. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1016/1071-5576(94)00050-b OpenAlex: https://openalex.org/W2093120626
    OpenAlex OpenCitations
  83. (s. d.). Centers for Disease Control and Prevention (CDC) (2017, July 05). Obesity and Overweight, Available online: https://www.cdc.gov/nchs/fastats/obesity-overweight.htm .
    Type: Autre
    Crossref
  84. Oliver Zierau , Ana C. Zenclussen , Federico Jensen (2012). Role of female sex hormones, estradiol and progesterone, in mast cell behavior . Frontiers in Immunology, 3, 169. Frontiers Media SA.
    Type: Article DOI: 10.3389/fimmu.2012.00169 OpenAlex: https://openalex.org/W2104761060
    Crossref OpenAlex OpenCitations
  85. Samar Musmar , Asma Afaneh , Hafsa Mo'alla (2013). Epidemiology of polycystic ovary syndrome: a cross sectional study of university students at An-Najah national university-Palestine . Reproductive Biology and Endocrinology, 11(1), 47. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/1477-7827-11-47 OpenAlex: https://openalex.org/W2169534828
    Crossref OpenAlex OpenCitations
  86. Julia Warren-Ulanch , Silva Arslanian (2006). Treatment of PCOS in adolescence . Best Practice & Research Clinical Endocrinology & Metabolism, 20(2), 311-330. Elsevier BV.
    Type: Article DOI: 10.1016/j.beem.2006.02.002 OpenAlex: https://openalex.org/W2097904067
    Crossref OpenAlex OpenCitations
  87. Suranjith L. Seneviratne , Anne Maitland , Lawrence Afrin (2017). Mast cell disorders in Ehlers–Danlos syndrome . American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 175(1), 226-236. Wiley.
    Type: Article DOI: 10.1002/ajmg.c.31555 OpenAlex: https://openalex.org/W2592443709
    Crossref OpenAlex OpenCitations
  88. Gehan Ahmed Mostafa , Laila Yousef Al-Ayadhi (2013). The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children . Journal of Neuroimmunology, 261(1-2), 77-81. Elsevier BV.
    Type: Article DOI: 10.1016/j.jneuroim.2013.04.003 OpenAlex: https://openalex.org/W2118067275
    Crossref OpenAlex OpenCitations
  89. Hjördís Ó. Atladóttir , Marianne G. Pedersen , Poul Thorsen , Preben Bo Mortensen , Bent Deleuran , William W. Eaton et al. (2009). Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders . Pediatrics, 124(2), 687-694. American Academy of Pediatrics (AAP).
    Type: Article DOI: 10.1542/peds.2008-2445 OpenAlex: https://openalex.org/W2129548794
    Crossref OpenAlex OpenCitations
  90. Inge De Wandele , Lies Rombaut , Luc Leybaert , Philippe Van de Borne , Tine De Backer , Fransiska Malfait et al. (2014). Dysautonomia and its underlying mechanisms in the hypermobility type of Ehlers–Danlos syndrome . Seminars in Arthritis and Rheumatism, 44(1), 93-100. Elsevier BV.
    Type: Article DOI: 10.1016/j.semarthrit.2013.12.006 OpenAlex: https://openalex.org/W2116432610
    Crossref OpenAlex OpenCitations
  91. Fransiska Malfait , Clair Francomano , Peter Byers , John Belmont , Britta Berglund , James Black et al. (2017). The 2017 international classification of the Ehlers–Danlos syndromes . American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 175(1), 8-26. Wiley.
    Type: Article DOI: 10.1002/ajmg.c.31552 OpenAlex: https://openalex.org/W2597004434
    Crossref OpenAlex OpenCitations
  92. Muldowney, P. T. K. (2015). Living Life to the Fullest with Ehlers-Danlos Syndrome: Guide to Living a Better Quality Life While Having EDS, Outskirts Press.
    Type: Autre
    Crossref
  93. Afrin, L. B. (2016). Never Bet Against Occam, Sisters Media, LLC.
    Type: Autre
    Crossref
  94. A J Hakim , R Grahame (2003). A simple questionnaire to detect hypermobility: an adjunct to the assessment of patients with diffuse musculoskeletal pain. PubMed, 57(3), 163-6.
    Type: Article OpenAlex: https://openalex.org/W2395992348
    OpenAlex
  95. Noctor (2011). Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex . Eur. J. Neurosci., 24, 3475.
    Type: Autre
    Crossref
  96. (s. d.). National Organization for Rare Disorders (NORD) (2017, June 18). Ehlers Danlos Syndrome. Available online: https://rarediseases.org/rare-diseases/ehlers-danlos-syndrome/#affected-populations .
    Type: Autre
    Crossref