Michelle Dawson posts

Post published on Twitter/X on 5 Jul 2021 13:59

Twitter/X Clinical trial clinicaltrials.gov DOI work crossref Extract quoted in the post Question asked by Dawson in the post External link integrated into the post Autism terms

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5 Jul 2021 14:14

Notes: 17% (12/72) of the PR-ESSENCE group dropped out, vs 3% (1/36) of controls. Trial started in March 2014 but wasn't registered until Dec 2018, see https://t.co/hukKWEDIiO & the name "PR-ESSENCE" did not appear in the trial registration until 2020, after study completion

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2 cited resources

Clinical trial Fetched Integrated reply clinicaltrials.gov

Göteborg University (2014). PR-ESSENCE for Youth With Challenging Behavior. ClinicalTrials.gov. Göteborg University.

Publication date
1 Mar 2014
Identifier
NCT03780413
Authors
Göteborg University
Source
ClinicalTrials.gov
Reference type
clinical_trial
Publisher
Göteborg University
Metadata source
clinicaltrials.gov

Abstract

The method "Collaborative and Proactive Solutions" (CPS) was developed by Dr. Ross Greene, Harvard University, to understand and help kids with social, emotional, and behavioral challenges. The underlying theory is that challenging behavior is caused by lagging cognitive skills, commonly in the domains of flexibility/adaptability, frustration tolerance, and problem-solving. Thus, challenging behavior can be seen as a form of developmental delay, and the most effective way for adults to help the children and to facilitate interaction with them is to understand the lagging skills behind the behavior and to change their own mindset accordingly. ADHD and autism belong in a group of overlapping neurodevelopmental conditions now often referred to under the umbrella term of ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations). A common impairing problem in both autism and ADHD - and in several of the other disorders in the group of ESSENCE (including Tourette syndrome and other tic disorders) - is the marked inability to control temper, coupled with oppositional-defiant behaviors. The CPS-method has been evaluated by Ross Greene et al. in United States studies for families, in schools, and in institutions for young people with serious behavior problems. Our research group published the first Swedish study with the method in 2012, a small open pilot study. Based on experiences in clinical work after that study our group reached the conclusion that, in order for the intervention to be useful for families with severely impairing ESSENCE, the CPS model needed to be modified. After a number of research meetings and seminars, we therefore designed a new model, based on our CPS-experience, that we now refer to as PR-ESSENCE (Problem Resolution in ESSENCE). The present study is a randomized controlled trial for approximately 130 children and adolescents aged 5-18 years, with neuropsychiatric disorders (for instance Attention Deficit Hyperactivity Disorder (ADHD), Oppositional Defiant Disorder (ODD), Conduct Disorder (CD), Autism Spectrum Disorder (ASD), Tourette syndrome, learning difficulties), children who have been assessed at our Child Neuropsychiatry Clinic (CNC), and from the Habilitation Services, Child Psychiatry Units or schools in the Göteborg region.

DOI work Fetched Post crossref

Mats Johnson, Carina Gillberg, Ingrid Vinsa, Gunnar Fransson, Lena Samuelsson, Klara Jakobsson, Sven Östlund, Elisabeth Fernell, et al. (2023). A randomized controlled trial of a new intervention in early symptomatic syndromes eliciting neurodevelopmental clinical examinations: PR-ESSENCE. European Child & Adolescent Psychiatry, 32(1), 63-74. Springer Science and Business Media LLC.

Publication date
3 Jul 2021
Identifier
10.1007/s00787-021-01837-z
Authors
Mats Johnson, Carina Gillberg, Ingrid Vinsa, Gunnar Fransson, Lena Samuelsson, Klara Jakobsson, Sven Östlund, Elisabeth Fernell, Christopher Gillberg
Source
European Child & Adolescent Psychiatry
Details
32(1), 63-74
Reference type
article
Publisher
Springer Science and Business Media LLC
Metadata source
crossref

Abstract

Abstract The need for effective intervention programs for youth with neurodevelopmental problems (ESSENCE) and challenging behaviour is great. This study examines Problem Resolution in ESSENCE (PR-ESSENCE), a newly developed model in which children and parents develop mutual problem resolution strategies. Ten-week randomized controlled trial of PR-ESSENCE for children and adolescents aged 5–18 years, compared to treatment as usual. Outcomes were assessed at baseline and randomized period endpoint. Primary outcome was the Clinical Global Impression—Improvement scale (CGI-I) rated by blinded assessors. Secondary outcomes were rated by parents—SNAP-IV, Eyberg Child Behavior Inventory (ECBI), Relationship Problems Questionnaire, Family Burden of Illness Module, and children—Beck Youth Inventories (BYI). ClinicalTrials.gov identifier: NCT03780413. The study enrolled 108 participants (active n = 72; controls n = 36, randomized 2:1), of whom 95 completed the randomized period. No clinically significant group differences were found in baseline characteristics. More than half had autism and 80% had ADD or ADHD. Large treatment effects were seen on CGI-I (ITT analysis, Effect Size 1.48). Treatment responders, much/very much improved on CGI-I, were 51.4% in active group and 5.6% of controls. Effect sizes were medium to large in parent ratings on SNAP-IV (ODD and ADHD symptoms), ECBI (behaviour problems), and in BYI child self-ratings of disruptive behaviour. PR-ESSENCE treatment improved global symptoms and functioning (CGI-I), behaviour problems, ADHD and ODD symptoms, and disruptive behaviour. Treatment effects were at least equivalent to those in previous studies of well-established Parent Management Training and Collaborative Problem Solving programs.

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