Up-Regulation of Oligodendrocyte Lineage Markers in the Cerebellum of Autistic Patients: Evidence from Network Analysis of Gene Expression

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Zeidán-Chuliá, F., de Oliveira, B. H. N., Casanova, E., Casanova, E., Noda, M., Salmina, A. B., & Verkhratsky, A. (2015). Up-Regulation of Oligodendrocyte Lineage Markers in the Cerebellum of Autistic Patients: Evidence from Network Analysis of Gene Expression. Molecular Neurobiology, 53(6), 4019-4025. https://doi.org/10.1007/s12035-015-9351-7

Publication date: 20 Jul 2015 Added to AutiHub: 14 Sep 2026 Type: Article Article language: English
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Authors

Publication authors
7
Publication authors identified as autistic
2 / 7 (28.6%)
  1. Fares Zeidán-Chuliá
  2. Ben-Hur Neves de Oliveira
  3. Emily L. Casanova *
  4. Emily L. Casanova *
  1. Mami Noda
  2. Alla B. Salmina
  3. Alexei Verkhratsky

Abstract

Autism is a neurodevelopmental disorder manifested by impaired social interaction, deficits in communication skills, restricted interests, and repetitive behaviors. In neurodevelopmental, neurodegenerative, and psychiatric disorders, glial cells undergo morphological, biochemical, and functional rearrangements, which are critical for neuronal development, neurotransmission, and synaptic connectivity. Cerebellar function is not limited to motor coordination but also contributes to cognition and may be affected in autism. Oligodendrocytes and specifically oligodendroglial precursors are highly susceptible to oxidative stress and excitotoxic insult. In the present study, we searched for evidence for developmental oligodendropathy in the context of autism by performing a network analysis of gene expression of cerebellar tissue. We created an in silico network model (OLIGO) showing the landscape of interactions between oligodendrocyte markers and demonstrated that more than 50 % (16 out of 30) of the genes within this model displayed significant changes of expression (corrected p value <0.05) in the cerebellum of autistic patients. In particular, we found up-regulation of OLIG2-, MBP-, OLIG1-, and MAG-specific oligodendrocyte markers. We postulate that aberrant expression of oligodendrocyte-specific genes, potentially related to changes in oligodendrogenesis, may contribute to abnormal cerebellar development, impaired myelination, and anomalous synaptic connectivity in autism spectrum disorders (ASD).

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Cited bibliography overview

These indicators describe the bibliography cited by this publication. An author name is counted each time it appears in one cited reference, so the same person can be counted more than once. Names not yet linked to an author already present in AutiHub are treated as unknown, not as non-autistic. Last computed: 20 Sep 2026 01:01.

Cited references
42
With a DOI
39
Without a DOI, from raw bibliography text
1
0 / 42 (0.0%) cited references include at least one author identified as autistic.
References with data to complete
1 / 42 (2.4%)
References with detected author names
42 / 42 (100.0%)
Without detected author names
0
Without a structured title
1
Without a stable identifier
1
References with raw author names still to review
0
References with external metadata lookup issues
0
These indicators apply to cited references displayed on this page, after technical duplicates have been merged. A reference without a DOI can still support author statistics when a title and author names are available.
Author names detected in the cited bibliography
285
From DOI or external metadata
285
From validated raw bibliography text
0
Raw names already validated
0
Raw names still to review
0
33 / 285 (11.6%) names are linked to an author already present in AutiHub. 252 / 285 (88.4%) names are not yet linked.
Names linked to a person identified as autistic
0 / 285 (0.0%)
Calculated across all author names detected in the cited bibliography. Among names linked to an author already present in AutiHub: 0 / 33 (0.0%). Distinct people identified as autistic: 0 / 260 (0.0%).
  1. K.B. Walhovd , H. Johansen-Berg , R.T. Káradóttir (2014). Unraveling the secrets of white matter – Bridging the gap between cellular, animal and human imaging studies . Neuroscience, 276, 2-13. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroscience.2014.06.058 OpenAlex: https://openalex.org/W1975478767
    Crossref OpenAlex OpenCitations
  2. SJ Blumberg (2013). Blumberg SJ, Bramlett MD, Kogan MD, Schieve LA, Jones JR (2013) Changes in prevalence of parent-reported autism spectrum disorder in school-aged U. S. children: 2007 to 2011–2012. Natl Health Stat Rep 65:1–12 Natl Health Stat Rep, 65, 1.
    Type: Other
    Crossref
  3. Eric Courchesne (1997). Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism . Current Opinion in Neurobiology, 7(2), 269-278. Elsevier BV.
    Type: Article DOI: 10.1016/s0959-4388(97)80016-5 OpenAlex: https://openalex.org/W2165792108
    Crossref OpenAlex OpenCitations
  4. B D Butts , C Houde , H Mehmet (2008). Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease . Cell Death & Differentiation, 15(7), 1178-1186. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/cdd.2008.70 OpenAlex: https://openalex.org/W1981385209
    Crossref OpenAlex OpenCitations
  5. Fares Zeidán-Chuliá , Ulvi K. Gursoy , Eija Könönen , Carmem Gottfried (2011). A dental look at the autistic patient through orofacial pain . Acta Odontologica Scandinavica, 69(4), 193-200. MJS Publishing, Medical Journals Sweden AB.
    Type: Article DOI: 10.3109/00016357.2010.549505 OpenAlex: https://openalex.org/W2092359029
    Crossref OpenAlex OpenCitations
  6. Erin M. Gibson , David Purger , Christopher W. Mount , Andrea K. Goldstein , Grant L. Lin , Lauren S. Wood et al. (2014). Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain . Science, 344(6183), 1252304. American Association for the Advancement of Science (AAAS).
    Type: Article DOI: 10.1126/science.1252304 OpenAlex: https://openalex.org/W2157257192
    Crossref OpenAlex OpenCitations
  7. Martin C. Raff , Barbara A. Barres , Julia F. Burne , Harriet S. Coles , Yasuki Ishizaki , Michael D. Jacobson (1993). Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System . Science, 262(5134), 695-700. American Association for the Advancement of Science (AAAS).
    Type: Article DOI: 10.1126/science.8235590 OpenAlex: https://openalex.org/W1982784171
    Crossref OpenAlex OpenCitations
  8. Fares Zeidán-Chuliá , José Luiz Rybarczyk-Filho , Alla B. Salmina , Ben-Hur Neves de Oliveira , Mami Noda , José Cláudio F. Moreira (2013). Exploring the Multifactorial Nature of Autism Through Computational Systems Biology: Calcium and the Rho GTPase RAC1 Under the Spotlight . NeuroMolecular Medicine, 15(2), 364-383. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s12017-013-8224-3 OpenAlex: https://openalex.org/W2043484704
    Crossref OpenAlex OpenCitations
  9. Shafali S. Jeste , Daniel H. Geschwind (2014). Disentangling the heterogeneity of autism spectrum disorder through genetic findings . Nature Reviews Neurology, 10(2), 74-81. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/nrneurol.2013.278 OpenAlex: https://openalex.org/W1984331840
    Crossref OpenAlex OpenCitations
  10. Abha Chauhan , Ved Chauhan (2006). Oxidative stress in autism . Pathophysiology, 13(3), 171-181. Elsevier BV.
    Type: Article DOI: 10.1016/j.pathophys.2006.05.007 OpenAlex: https://openalex.org/W2128294896
    Crossref OpenAlex OpenCitations
  11. Stephen A. Back , Xiaodong Gan , Ya Li , Paul A. Rosenberg , Joseph J. Volpe (1998). Maturation-Dependent Vulnerability of Oligodendrocytes to Oxidative Stress-Induced Death Caused by Glutathione Depletion . The Journal of Neuroscience, 18(16), 6241-6253. Society for Neuroscience.
    Type: Article DOI: 10.1523/jneurosci.18-16-06241.1998 OpenAlex: https://openalex.org/W2146317119
    Crossref OpenAlex OpenCitations
  12. Wenbin Deng , Ronald D Poretz (2003). Oligodendroglia in Developmental Neurotoxicity . NeuroToxicology, 24(2), 161-178. Elsevier BV.
    Type: Article DOI: 10.1016/s0161-813x(02)00196-1 OpenAlex: https://openalex.org/W1985757554
    Crossref OpenAlex OpenCitations
  13. Fares Zeidán-Chuliá , Alla B. Salmina , Natalia A. Malinovskaya , Mami Noda , Alexei Verkhratsky , José Cláudio Fonseca Moreira (2014). The glial perspective of autism spectrum disorders . Neuroscience & Biobehavioral Reviews, 38, 160-172. Elsevier BV.
    Type: Article DOI: 10.1016/j.neubiorev.2013.11.008 OpenAlex: https://openalex.org/W2069866156
    Crossref OpenAlex OpenCitations
  14. Marta Gozzi , Dylan M. Nielson , Rhoshel K. Lenroot , John L. Ostuni , David A. Luckenbaugh , Audrey Thurm et al. (2012). A Magnetization Transfer Imaging Study of Corpus Callosum Myelination in Young Children with Autism . Biological Psychiatry, 72(3), 215-220. Elsevier BV.
    Type: Article DOI: 10.1016/j.biopsych.2012.01.026 OpenAlex: https://openalex.org/W1988996835
    Crossref OpenAlex OpenCitations
  15. Fares Zeidán-Chuliá , B-HN de Oliveira , A B Salmina , Manuel F. Casanova , D P Gelain , Mami Noda et al. (2014). Altered expression of Alzheimer’s disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy . Cell Death & Disease, 5(5), e1250-e1250. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/cddis.2014.227 OpenAlex: https://openalex.org/W1998046507
    Crossref OpenAlex OpenCitations
  16. Matthew R. Ginsberg , Robert A. Rubin , Tatiana Falcone , Angela H. Ting , Marvin R. Natowicz (2012). Brain Transcriptional and Epigenetic Associations with Autism . PLoS ONE, 7(9), e44736. Public Library of Science (PLoS).
    Type: Article DOI: 10.1371/journal.pone.0044736 OpenAlex: https://openalex.org/W2077232248
    Crossref OpenAlex OpenCitations
  17. Manuel F. Casanova , Daniel P. Buxhoeveden , Caroline Brown (2002). Clinical and Macroscopic Correlates of Minicolumnar Pathology in Autism . Journal of Child Neurology, 17(9), 692-695. SAGE Publications.
    Type: Article DOI: 10.1177/088307380201700908 OpenAlex: https://openalex.org/W2001627723
    Crossref OpenAlex OpenCitations
  18. Jerzy Wegiel , Izabela Kuchna , Krzysztof Nowicki , Humi Imaki , Jarek Wegiel , Elaine Marchi et al. (2010). The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes . Acta Neuropathologica, 119(6), 755-770. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s00401-010-0655-4 OpenAlex: https://openalex.org/W2046683077
    Crossref OpenAlex OpenCitations
  19. Robert C Gentleman , Vincent J Carey , Douglas M Bates , Ben Bolstad , Marcel Dettling , Sandrine Dudoit et al. (2004). Bioconductor: open software development for computational biology and bioinformatics . Genome Biology, 5(10). Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/gb-2004-5-10-r80 10.21256/zhaw-1907 10.3929/ethz-b-000160918
    OpenCitations
  20. ANTONIO Y. HARDAN , NANCY J. MINSHEW , KEITH HARENSKI , MATCHERI S. KESHAVAN (2001). Posterior Fossa Magnetic Resonance Imaging in Autism . Journal of the American Academy of Child & Adolescent Psychiatry, 40(6), 666-672. Elsevier BV.
    Type: Article DOI: 10.1097/00004583-200106000-00011 OpenAlex: https://openalex.org/W2002380530
    Crossref OpenAlex OpenCitations
  21. S. Hossein Fatemi , Kimberly A. Aldinger , Paul Ashwood , Margaret Bauman , Charles D. Blaha , Gene J. Blatt et al. (2012). Consensus Paper: Pathological Role of the Cerebellum in Autism . The Cerebellum, 11(3), 777-807. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s12311-012-0355-9 OpenAlex: https://openalex.org/W2020374060
    Crossref OpenAlex OpenCitations
  22. Mark D. Shen , Christine Wu Nordahl , Gregory S. Young , Sandra L. Wootton-Gorges , Aaron Lee , Sarah E. Liston et al. (2013). Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder . Brain, 136(9), 2825-2835. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/brain/awt166 OpenAlex: https://openalex.org/W2116471897
    Crossref OpenAlex OpenCitations
  23. Nicole Baumann , Danielle Pham-Dinh (2001). Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System . Physiological Reviews, 81(2), 871-927. American Physiological Society.
    Type: Article DOI: 10.1152/physrev.2001.81.2.871 OpenAlex: https://openalex.org/W2125650861
    Crossref OpenAlex OpenCitations
  24. Natacha Akshoomoff , Catherine Lord , Alan J. Lincoln , Rachel Y. Courchesne , Ruth A. Carper , Jeanne Townsend et al. (2004). Outcome Classification of Preschool Children With Autism Spectrum Disorders Using MRI Brain Measures . Journal of the American Academy of Child & Adolescent Psychiatry, 43(3), 349-357. Elsevier BV.
    Type: Article DOI: 10.1097/00004583-200403000-00018 OpenAlex: https://openalex.org/W2024107088
    Crossref OpenAlex OpenCitations
  25. E. Courchesne , C. M. Karns , H. R. Davis , R. Ziccardi , R. A. Carper , Z. D. Tigue et al. (2001). Unusual brain growth patterns in early life in patients with autistic disorder . Neurology, 57(2), 245-254. Ovid Technologies (Wolters Kluwer Health).
    Type: Article DOI: 10.1212/wnl.57.2.245 OpenAlex: https://openalex.org/W2025551837
    Crossref OpenAlex OpenCitations
  26. David G. Amaral , Cynthia Mills Schumann , Christine Wu Nordahl (2008). Neuroanatomy of autism . Trends in Neurosciences, 31(3), 137-145. Elsevier BV.
    Type: Article DOI: 10.1016/j.tins.2007.12.005 OpenAlex: https://openalex.org/W2129179498
    Crossref OpenAlex OpenCitations
  27. Jane Libbey , Thayne Sweeten , William McMahon , Robert Fujinami (2005). Autistic disorder and viral infections . Journal of NeuroVirology, 11(1), 1-10. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1080/13550280590900553 OpenAlex: https://openalex.org/W2119855769
    Crossref OpenAlex OpenCitations
  28. Eric Courchesne , Karen Pierce (2005). Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection . Current Opinion in Neurobiology, 15(2), 225-230. Elsevier BV.
    Type: Article DOI: 10.1016/j.conb.2005.03.001 OpenAlex: https://openalex.org/W2131541104
    Crossref OpenAlex OpenCitations
  29. Janet Hendry , Timothy DeVito , Neil Gelman , Maria Densmore , Nagalingam Rajakumar , William Pavlosky et al. (2006). White matter abnormalities in autism detected through transverse relaxation time imaging . NeuroImage, 29(4), 1049-1057. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2005.08.039 OpenAlex: https://openalex.org/W2044349722
    Crossref OpenAlex OpenCitations
  30. Bilal El Waly , Magali Macchi , Myriam Cayre , Pascale Durbec (2014). Oligodendrogenesis in the normal and pathological central nervous system . Frontiers in Neuroscience, 8, 145. Frontiers Media SA.
    Type: Article DOI: 10.3389/fnins.2014.00145 OpenAlex: https://openalex.org/W2046170972
    Crossref OpenAlex OpenCitations
  31. Alexei Verkhratsky , Frank Kirchhoff (2007). NMDA Receptors in Glia . The Neuroscientist, 13(1), 28-37. SAGE Publications.
    Type: Article DOI: 10.1177/1073858406294270 OpenAlex: https://openalex.org/W2126134918
    Crossref OpenAlex OpenCitations
  32. Shawn K. Thorburne , Bernhard H. J. Juurlink (1996). Low Glutathione and High Iron Govern the Susceptibility of Oligodendroglial Precursors to Oxidative Stress . Journal of Neurochemistry, 67(3), 1014-1022. Wiley.
    Type: Article DOI: 10.1046/j.1471-4159.1996.67031014.x OpenAlex: https://openalex.org/W2056216741
    Crossref OpenAlex OpenCitations
  33. D. Szklarczyk , A. Franceschini , M. Kuhn , M. Simonovic , A. Roth , P. Minguez et al. (2011). The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored . Nucleic Acids Res, 39(Database issue), D561. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/nar/gkq973 OpenAlex: https://openalex.org/W2057545775
    Crossref OpenAlex
  34. Sean D. Hooper , Peer Bork (2005). Medusa: a simple tool for interaction graph analysis . Bioinformatics, 21(24), 4432-4433. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/bioinformatics/bti696 OpenAlex: https://openalex.org/W2111627817
    Crossref OpenAlex OpenCitations
  35. Carole Mathis , Ludovic Collin , Emiliana Borrelli (2003). Oligodendrocyte ablation impairs cerebellum development . Development, 130(19), 4709-4718. The Company of Biologists.
    Type: Article DOI: 10.1242/dev.00675 OpenAlex: https://openalex.org/W2058969219
    Crossref OpenAlex OpenCitations
  36. D. Szklarczyk , A. Franceschini , M. Kuhn , M. Simonovic , A. Roth , P. Minguez et al. (2011). The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored . Nucleic Acids Research, 39(Database), D561-D568. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/nar/gkq973 10.5167/uzh-41629
    OpenCitations
  37. Robert C Gentleman , Vincent J Carey , Douglas M Bates , Ben Bolstad , Marcel Dettling , Sandrine Dudoit et al. (2004). Bioconductor: open software development for computational biology and bioinformatics . Genome Biol, 5(10), R80. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/gb-2004-5-10-r80 OpenAlex: https://openalex.org/W2160697532
    Crossref OpenAlex
  38. Y. Pawitan , S. Michiels , S. Koscielny , A. Gusnanto , A. Ploner (2005). False discovery rate, sensitivity and sample size for microarray studies . Bioinformatics, 21(13), 3017-3024. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/bioinformatics/bti448 OpenAlex: https://openalex.org/W2128909276
    Crossref OpenAlex OpenCitations
  39. Stephen J Blumberg , Matthew D Bramlett , Michael D. Kogan , Laura A Schieve , Jessica R Jones , Michael C Lu (2013). Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children: 2007 to 2011-2012. PubMed, (65), 1-11, 1 p following 11.
    Type: Article OpenAlex: https://openalex.org/W2103590925
    OpenAlex
  40. Dennis P. Carmody , Michael Lewis (2010). Regional white matter development in children with autism spectrum disorders . Developmental Psychobiology, 52(8), 755-763. Wiley.
    Type: Article DOI: 10.1002/dev.20471 OpenAlex: https://openalex.org/W2118095155
    Crossref OpenAlex OpenCitations
  41. E. S. Bell , M. Park (2012). Models of Crk Adaptor Proteins in Cancer . Genes & Cancer, 3(5-6), 341-352. SAGE Publications.
    Type: Article DOI: 10.1177/1947601912459951 OpenAlex: https://openalex.org/W2160315153
    Crossref OpenAlex OpenCitations
  42. Stephen J. Blumberg , Matthew D. Bramlett , Michael D. Kogan , Laura A. Schieve , Jessica R. Jones , Michael C. Lu (2013). Changes in Prevalence of Parent-Reported Autism Spectrum Disorder in School-Aged U.S. Children: 2007 to 2011-2012. National Center for Health Statistics Reports. Number 65.
    Type: Article OpenAlex: https://openalex.org/W2899353575
    OpenAlex