Editorial: Secondary vs. Idiopathic Autism

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Casanova, M. F., Casanova, M., Frye, R. E., Baeza-Velasco, C., LaSalle, J. M., Hagerman, R. J., Scherer, S. W., & Natowicz, M. R. (2020). Editorial: Secondary vs. Idiopathic Autism. Frontiers in Psychiatry, 11, 297-297. https://doi.org/10.3389/fpsyt.2020.00297

Publication date: 14 Apr 2020 Added to AutiHub: 14 Sep 2026 Type: Article Article language: English
Publisher source (DOI) Full text OpenAlex source

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Authors

Publication authors
8
Publication authors identified as autistic
1 / 8 (12.5%)
  1. Manuel F. Casanova
  2. Manuel Casanova *
  3. Richard Eugene Frye
  4. Carolina Baeza-Velasco
  1. Janine M. LaSalle
  2. Randi Jensen Hagerman
  3. Stephen W. Scherer
  4. Marvin R. Natowicz

Abstract

Secondary vs. Idiopathic AutismThis Research Topic consists of four articles, contributed by 30 authors, each focusing on various aspects of secondary autism spectrum disorder (ASD).The articles in this Research Topic discuss some of the controversies and progress made in how to assess a child with secondary ASD.They discuss the utility of using genetic and metabolic tests, as well as combinations of the same.They also grapple with the relationship of intellectual disability (ID) and other symptoms in patients with secondary ASD.The diagnostic boundaries of the behavioral phenotype that define ASD are fairly broad due to the large variability that is observed in symptom types, onset, and severity.This variability serves as an index of etiological heterogeneity for a group of complex conditions where multiple genetic/ environmental hits provide an additive burden to symptom expression.Within this spectrum of disorders our Research Topic examines a subpopulation of patients where the ASD phenotype occurs and a specific cause can be identified (1).These cases are often referred to as "secondary" ASD as a way of distinguishing them from "idiopathic" ASD.While there is some variation of the estimates, about 85% of individuals with ASD are termed as having idiopathic ASD with about 15% diagnosed with secondary ASD (2).Cases of secondary ASD display significant etiological diversity and, sometimes, more severe behavioral problems than individuals having idiopathic ASD (3, 4).Well documented causes of secondary ASD include conditions such as tuberous sclerosis, down syndrome, Fragile X syndrome (FXS), and some congenital infections (e.g., cytomegalovirus) (5-7).Differentiating between idiopathic and secondary ASD is essential when drawing conclusions regarding pharmacological and behavioral treatments among published studies (8).Clinical study design benefits from the selection of homogeneous populations, those without prognostically distinct subgroups, as it makes it easier to assess treatment efficacy (vide infra, (9)].Indeed, a thorough understanding of the different clinical presentations, natural history and even life expectancies of persons with ASD should go beyond the influence of traditional variables and use relevant classifiers of biomedical and sociocultural differences that may have an impact on the health and wellbeing of the studied subject population.Genomic scanning is beginning to elucidate the underlying genetic architecture that confers ASD susceptibility.Chromosomal and penetrant gene abnormalities are common, contributing to about 5%-15% of ASD cases in some estimates (10).By way of contrast, de novo chromosomal copy number variants, important contributors to lower IQ, and diminished motor skills (11), are seen in

Bibliography cited by this reference

Cited references are imported from external metadata sources when they are available. The list may be partial.

Cited bibliography overview

These indicators describe the bibliography cited by this publication. An author name is counted each time it appears in one cited reference, so the same person can be counted more than once. Names not yet linked to an author already present in AutiHub are treated as unknown, not as non-autistic. Last computed: 14 Sep 2026 14:22.

Cited references
19
With a DOI
18
Without a DOI, from raw bibliography text
1
0 / 19 (0.0%) cited references include at least one author identified as autistic.
References with data to complete
1 / 19 (5.3%)
References with detected author names
18 / 19 (94.7%)
Without detected author names
1
Without a structured title
1
Without a stable identifier
1
References with raw author names still to review
0
References with external metadata lookup issues
0
These indicators apply to cited references displayed on this page, after technical duplicates have been merged. A reference without a DOI can still support author statistics when a title and author names are available.
Author names detected in the cited bibliography
171
From DOI or external metadata
171
From validated raw bibliography text
0
Raw names already validated
0
Raw names still to review
0
37 / 171 (21.6%) names are linked to an author already present in AutiHub. 134 / 171 (78.4%) names are not yet linked.
Names linked to a person identified as autistic
0 / 171 (0.0%)
Calculated across all author names detected in the cited bibliography. Among names linked to an author already present in AutiHub: 0 / 37 (0.0%). Distinct people identified as autistic: 0 / 159 (0.0%).
  1. Max Wiznitzer (2004). Autism and Tuberous Sclerosis . Journal of Child Neurology, 19(9), 675-679. SAGE Publications.
    Type: Article DOI: 10.1177/08830738040190090701 OpenAlex: https://openalex.org/W1545203440
    Crossref OpenAlex OpenCitations
  2. Hadeel Faras , Nahed Al Ateeqi , Lee Tidmarsh (2010). Autism spectrum disorders . Annals of Saudi Medicine, 30(4), 295-300. King Faisal Specialist Hospital and Research Centre.
    Type: Article DOI: 10.4103/0256-4947.65261 OpenAlex: https://openalex.org/W4252297753
    Crossref OpenAlex OpenCitations
  3. Richard Eugene Frye , Sarah G. Vassall , Gurjot Kaur , Christina Lewis , Mohammand Karim , Daniel Rossignol (2019). Emerging biomarkers in autism spectrum disorder: a systematic review . Annals of Translational Medicine, 7(23), 792-792. AME Publishing Company.
    Type: Article DOI: 10.21037/atm.2019.11.53 OpenAlex: https://openalex.org/W2989987020
    Crossref OpenAlex OpenCitations
  4. Katrina Williams , Amanda Brignell , Melinda Randall , Natalie Silove , Philip Hazell (2013). Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD) . Cochrane Database of Systematic Reviews, 2013(8), Cd004677. Wiley.
    Type: Article DOI: 10.1002/14651858.cd004677.pub3 OpenAlex: https://openalex.org/W1906903025
    Crossref OpenAlex OpenCitations
  5. (n.d.). About autism
    Type: Other
    Crossref
  6. Christian P Schaaf , Huda Y. Zoghbi (2011). Solving the Autism Puzzle a Few Pieces at a Time . Neuron, 70(5), 806-808. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuron.2011.05.025 10.1016/j.neuron.2011.06.014
    OpenCitations
  7. Christian P Schaaf , Huda Y. Zoghbi (2011). Solving the autism puzzle a few pieces at a time . Neuron., 70(5), 806-808. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuron.2011.05.025 OpenAlex: https://openalex.org/W1975340400
    Crossref OpenAlex
  8. Kristiina Tammimies , Christian R. Marshall , Susan Walker , Gaganjot Kaur , Bhooma Thiruvahindrapuram , Anath C. Lionel et al. (2015). Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder . JAMA, 314(9), 895. American Medical Association (AMA).
    Type: Article DOI: 10.1001/jama.2015.10078 OpenAlex: https://openalex.org/W2128274087
    Crossref OpenAlex OpenCitations
  9. Anne C. Wheeler , Joanna Mussey , Adrienne Villagomez , Ellen Bishop , Melissa Raspa , Anne Edwards et al. (2015). DSM-5 Changes and the Prevalence of Parent-Reported Autism Spectrum Symptoms in Fragile X Syndrome . Journal of Autism and Developmental Disorders, 45(3), 816-829. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-014-2246-z OpenAlex: https://openalex.org/W2049281794
    Crossref OpenAlex OpenCitations
  10. Susan L. Smalley , Peter E. Tanguay , Moyra Smith , Griselda Gutierrez (1992). Autism and tuberous sclerosis . Journal of Autism and Developmental Disorders, 22(3), 339-355. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/bf01048239 OpenAlex: https://openalex.org/W1997714374
    OpenAlex
  11. Bernie Devlin , Stephen W. Scherer (2012). Genetic architecture in autism spectrum disorder . Current Opinion in Genetics & Development, 22(3), 229-237. Elsevier BV.
    Type: Article DOI: 10.1016/j.gde.2012.03.002 OpenAlex: https://openalex.org/W2002780340
    Crossref OpenAlex OpenCitations
  12. Jo Moss , Caroline Richards , Lisa Nelson , Chris Oliver (2013). Prevalence of autism spectrum disorder symptomatology and related behavioural characteristics in individuals with Down syndrome . Autism, 17(4), 390-404. SAGE Publications.
    Type: Article DOI: 10.1177/1362361312442790 OpenAlex: https://openalex.org/W2169544120
    Crossref OpenAlex OpenCitations
  13. Laura Greiss Hess , Sarah E. Fitzpatrick , Danh V. Nguyen , Yanjun Chen , Kimberly N. Gaul , Andrea Schneider et al. (2016). A Randomized, Double-Blind, Placebo-Controlled Trial of Low-Dose Sertraline in Young Children With Fragile X Syndrome . Journal of Developmental & Behavioral Pediatrics, 37(8), 619-628. Ovid Technologies (Wolters Kluwer Health).
    Type: Article DOI: 10.1097/dbp.0000000000000334 OpenAlex: https://openalex.org/W2518541914
    Crossref OpenAlex OpenCitations
  14. Renata Rizzo , Piero Pavone (2016). Aripiprazole for the treatment of irritability and aggression in children and adolescents affected by autism spectrum disorders . Expert Review of Neurotherapeutics, 16(8), 867-874. Informa UK Limited.
    Type: Article DOI: 10.1080/14737175.2016.1211007 OpenAlex: https://openalex.org/W2460264744
    Crossref OpenAlex OpenCitations
  15. Lonnie Zwaigenbaum , Margaret Bauman , Roula Choueiri , CONNIE KASARI , Alice Carter , Doreen Granpeesheh et al. (2015). Early intervention for children with autism spectrum disorder under 3 years of age: recommendations for practice and research . Pediatrics, 136(Supplement_1), S60-S81. American Academy of Pediatrics (AAP).
    Type: Article DOI: 10.1542/peds.2014-3667e OpenAlex: https://openalex.org/W2173495842
    Crossref OpenAlex
  16. Andreas Buja , Natalia Volfovsky , Abba M. Krieger , Catherine Lord , Alex E. Lash , Michael Wigler et al. (2018). Damaging de novo mutations diminish motor skills in children on the autism spectrum . Proceedings of the National Academy of Sciences, 115(8), E1859. National Academy of Sciences.
    Type: Article DOI: 10.1073/pnas.1715427115 OpenAlex: https://openalex.org/W2793693180
    Crossref OpenAlex OpenCitations
  17. Manman Niu , Ying Han , Angel Belle C. Dy , Junbao Du , Hongfang Jin , Jiong Qin et al. (2017). Autism Symptoms in Fragile X Syndrome . Journal of Child Neurology, 32(10), 903-909. SAGE Publications.
    Type: Article DOI: 10.1177/0883073817712875 OpenAlex: https://openalex.org/W2625029613
    Crossref OpenAlex OpenCitations
  18. Susan L. Hyman , Susan E. Levy , Scott M. Myers , COUNCIL ON CHILDREN WITH DISABILITIES, SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS , Dennis Z. Kuo , Susan Apkon et al. (2020). Identification, Evaluation, and Management of Children With Autism Spectrum Disorder . Pediatrics, 145(1), e20193447. American Academy of Pediatrics (AAP).
    Type: Article DOI: 10.1542/peds.2019-3447 OpenAlex: https://openalex.org/W2995148308
    Crossref OpenAlex OpenCitations
  19. Lonnie Zwaigenbaum , Margaret Bauman , Roula Choueiri , CONNIE KASARI , Alice Carter , Doreen Granpeesheh et al. (2020). Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research . In Pediatric Collections: Autism Spectrum Disorder (pp. 269-290). American Academy of Pediatrics.
    Type: Book chapter DOI: 10.1542/9781610024716-part06-ch023 10.1542/peds.2014-3667e
    OpenCitations