L'hypoconnectivité du réseau du mode par défaut sous-tend un spectre de l'autisme lié au sexe

Titre original en anglais : Default Mode Hypoconnectivity Underlies a Sex-Related Autism Spectrum

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Ypma, R. J., Moseley, R., Holt, R., Rughooputh, N., Floris, D. L., Chura, L. R., Spencer, M. D., Baron-Cohen, S., Suckling, J., Bullmore, E. T., & Rubinov, M. (2016). Default Mode Hypoconnectivity Underlies a Sex-Related Autism Spectrum. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1(4), 364-371. https://doi.org/10.1016/j.bpsc.2016.04.006

Date de publication: 06/05/2016 Ajout dans AutiHub: 06/07/2026 Type: Article Langue de l’article: Anglais
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Auteurs

Auteur·ices des publications
11
Auteur·ices de la publication identifié·es comme autistes
1 / 11 (9,1 %)
  1. Rolf J.F. Ypma
  2. Rachel Moseley *
  3. Rosemary Holt
  4. Naresh Rughooputh
  1. Dorothea L. Floris
  2. Lindsay R. Chura
  3. Michael D. Spencer
  4. Simon Baron-Cohen
  1. John Suckling
  2. Edward T. Bullmore
  3. Mikail Rubinov

Résumé

Les femmes et les hommes diffèrent significativement quant à la prévalence et à la présentation des troubles du spectre de l'autisme. Une théorie de cet effet postule que les traits autistiques se situent sur un continuum lié au sexe dans la population générale, et que l'autisme représente l'extrémité masculine de ce spectre. Cette théorie prédit que toute caractéristique de l'autisme chez les hommes devrait 1) être présente chez les femmes autistes, 2) différencier les sexes dans la population typique, et 3) être corrélée aux traits autistiques. Nous avons testé ces trois prédictions pour l'hypoconnectivité du réseau du mode par défaut (DMN) pendant l'état de repos, l'une des différences neurobiologiques les plus robustes observées dans l'autisme. Nous avons analysé un jeu de données principal portant sur des adolescents (N = 121, âgés de 12 à 18 ans) comprenant un nombre relativement élevé de femmes, ainsi qu'un jeu de données de réplication multisite incluant des enfants, des adolescents et des adultes (N = 980, âgés de 6 à 58 ans). Nous avons quantifié la connectivité moyenne entre les régions du DMN et testé les différences entre groupes ainsi que la corrélation avec la performance comportementale à l'aide d'une régression robuste. Nous avons observé des différences significatives d'intraconnectivité du DMN entre les femmes témoins et les femmes autistes (p =.001 dans le jeu de données principal ; p =.009 dans le jeu de données de réplication), et entre les femmes témoins et les hommes témoins (p =.036 dans le jeu de données principal ; p =.002 dans le jeu de données de réplication). Nous avons également observé une corrélation significative entre l'intraconnectivité du DMN et la performance à une tâche de mentalisation (p =.001) dans le jeu de données principal. Collectivement, ces résultats fournissent les premières preuves de l'hypoconnectivité du DMN en tant que phénotype de neuroimagerie comportementalement pertinent du spectre des traits autistiques lié au sexe, dont l'autisme représente le cas extrême.

Females and males differ significantly in the prevalence and presentation of autism spectrum conditions. One theory of this effect postulates that autistic traits lie on a sex-related continuum in the general population, and autism represents the extreme male end of this spectrum. This theory predicts that any feature of autism in males should 1) be present in autistic females, 2) differentiate between the sexes in the typical population, and 3) correlate with autistic traits. We tested these three predictions for default mode network (DMN) hypoconnectivity during the resting state, one of the most robustly found neurobiological differences in autism. We analyzed a primary dataset of adolescents (N = 121, 12–18 years of age) containing a relatively large number of females and a replication multisite dataset including children, adolescents, and adults (N = 980, 6–58 years of age). We quantified the average connectivity between DMN regions and tested for group differences and correlation with behavioral performance using robust regression. We found significant differences in DMN intraconnectivity between female controls and females with autism (p =.001 in the primary dataset; p =.009 in the replication dataset), and between female controls and male controls (p =.036 in the primary dataset; p =.002 in the replication dataset). We also found a significant correlation between DMN intraconnectivity and performance on a mentalizing task (p =.001) in the primary dataset. Collectively, these findings provide the first evidence for DMN hypoconnectivity as a behaviorally relevant neuroimaging phenotype of the sex-related spectrum of autistic traits, of which autism represents the extreme case.

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Ces indicateurs décrivent la bibliographie citée importée pour cette publication. Les métriques de références citées utilisent le total des références citées comme dénominateur. Les métriques d’auteurices cité·es indiquent si elles utilisent toutes les occurrences d’auteurices cité·es ou seulement les occurrences rattachées à des auteurices déjà intégré·es à la base de données AutiHub. Ils utilisent les rattachements mis en cache entre les auteurices cité·es et les auteurices intégré·es à la base de données AutiHub. Dernier calcul : 16/08/2026 11:31.

Références citées
93
Nombre total de références citées intégrées pour cette publication.
Références citées avec un·e auteur·ice identifié·e comme autiste
1 / 93 (1,1 %)
Occurrences d’auteur·ices cité·es identifié·es comme autistes
1 / 599 (0,2 %)
Parmi les occurrences rattachées à des auteurices intégré·es à la base de données AutiHub : 1 / 128 (0,8 %). Auteurices cité·es distinct·es identifié·es comme autistes : 1 / 450 (0,2 %).
Occurrences citées rattachées à la base AutiHub
128 / 599 (21,4 %)
Auteurices cité·es distinct·es rattaché·es : 39 / 450 (8,7 %)
Occurrences rattachées, non identifiées comme autistes
127 / 128 (99,2 %)
Parmi les seules occurrences rattachées. Sur l’ensemble des occurrences d’auteurices cité·es : 127 / 599 (21,2 %). Auteurices cité·es distinct·es rattaché·es, non identifié·es comme autistes : 38 / 39 (97,4 %).
  1. CINNAMON S. BLOSS , ERIC COURCHESNE (2007). MRI Neuroanatomy in Young Girls With Autism . Journal of the American Academy of Child & Adolescent Psychiatry, 46(4), 515-523. Elsevier BV.
    Type: Article DOI: 10.1097/chi.0b013e318030e28b OpenAlex: https://openalex.org/W67855444
    Crossref OpenAlex OpenCitations
  2. Suniti Chakrabarti , Éric Fombonne (2005). Pervasive Developmental Disorders in Preschool Children: Confirmation of High Prevalence . American Journal of Psychiatry, 162(6), 1133-1141. American Psychiatric Association Publishing.
    Type: Article DOI: 10.1176/appi.ajp.162.6.1133 OpenAlex: https://openalex.org/W2117154339
    Crossref OpenAlex OpenCitations
  3. Irit Weissman‐Fogel , Massieh Moayedi , Keri S. Taylor , Geoff Pope , Karen D. Davis (2010). Cognitive and default‐mode resting state networks: Do male and female brains “rest” differently? Human Brain Mapping, 31(11), 1713-1726. Wiley.
    Type: Article DOI: 10.1002/hbm.20968 OpenAlex: https://openalex.org/W2112713223
    Crossref OpenAlex OpenCitations
  4. Stuart D. Washington , Evan M. Gordon , Jasmit Brar , Samantha Warburton , Alice T. Sawyer , Amanda Wolfe et al. (2014). Dysmaturation of the default mode network in autism . Human Brain Mapping, 35(4), 1284-1296. Wiley.
    Type: Article DOI: 10.1002/hbm.22252 OpenAlex: https://openalex.org/W1496570496
    Crossref OpenAlex OpenCitations
  5. Ellen Giarelli , Lisa D. Wiggins , Catherine E. Rice , Susan E. Levy , Russell S. Kirby , Jennifer Pinto-Martin et al. (2010). Sex differences in the evaluation and diagnosis of autism spectrum disorders among children . Disability and Health Journal, 3(2), 107-116. Elsevier BV.
    Type: Article DOI: 10.1016/j.dhjo.2009.07.001 OpenAlex: https://openalex.org/W2064689669
    Crossref OpenAlex OpenCitations
  6. Ameera X. Patel , Prantik Kundu , Mikail Rubinov , P. Simon Jones , Petra E. Vértes , Karen D. Ersche et al. (2014). A wavelet method for modeling and despiking motion artifacts from resting-state fMRI time series . NeuroImage, 95, 287-304. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2014.03.012 OpenAlex: https://openalex.org/W2050597556
    Crossref OpenAlex OpenCitations
  8. Sander Begeer , David S. Mandell , Bernadette Wijnker-Holmes , Stance Venderbosch , Dorien Rem , Fred Stekelenburg et al. (2013). Sex Differences in the Timing of Identification Among Children and Adults with Autism Spectrum Disorders . Journal of Autism and Developmental Disorders, 43(5), 1151-1156. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-012-1656-z OpenAlex: https://openalex.org/W1990581042
    Crossref OpenAlex OpenCitations
  9. Simon Baron-Cohen , Daniel C. Bowen , Rosemary Holt , Carrie Allison , Bonnie Auyeung , Michael Lombardo et al. (2015). The “Reading the Mind in the Eyes” Test: Complete Absence of Typical Sex Difference in ~400 Men and Women with Autism . PLOS ONE, 10(8), e0136521. Public Library of Science (PLoS).
    Type: Article DOI: 10.1371/journal.pone.0136521 OpenAlex: https://openalex.org/W1943649909
    Crossref OpenAlex OpenCitations
  10. Meng-Chuan Lai , Michael Lombardo , Bonnie Auyeung , Bhismadev Chakrabarti , Simon Baron-Cohen (2015). Sex/Gender Differences and Autism: Setting the Scene for Future Research . Journal of the American Academy of Child & Adolescent Psychiatry, 54(1), 11-24. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaac.2014.10.003 OpenAlex: https://openalex.org/W2069328123
    Crossref OpenAlex OpenCitations
  11. Meng-Chuan Lai , Michael Lombardo , Amber Ruigrok , Bhismadev Chakrabarti , Sally J. Wheelwright , Bonnie Auyeung et al. (2012). Cognition in Males and Females with Autism: Similarities and Differences . PLoS ONE, 7(10), e47198. Public Library of Science (PLoS).
    Type: Article DOI: 10.1371/journal.pone.0047198 OpenAlex: https://openalex.org/W1983626034
    Crossref OpenAlex OpenCitations
  12. Dina R. Dajani , Lucina Q. Uddin (2016). Local brain connectivity across development in autism spectrum disorder: A cross‐sectional investigation . Autism Research, 9(1), 43-54. Wiley.
    Type: Article DOI: 10.1002/aur.1494 OpenAlex: https://openalex.org/W1957322185
    Crossref OpenAlex OpenCitations
  13. Gould (2011). Missed diagnosis or misdiagnosis? Girls and women on the autism spectrum . Good Autism Pract, 12, 34.
    Type: Autre
    Crossref
  14. Ai-Min Bao , Dick F. Swaab (2011). Sexual differentiation of the human brain: Relation to gender identity, sexual orientation and neuropsychiatric disorders . Frontiers in Neuroendocrinology, 32(2), 214-226. Elsevier BV.
    Type: Article DOI: 10.1016/j.yfrne.2011.02.007 OpenAlex: https://openalex.org/W2020701657
    Crossref OpenAlex OpenCitations
  15. Hans Asperger (1944). Die „Autistischen Psychopathen” im Kindesalter . Archiv für Psychiatrie und Nervenkrankheiten, 117(1), 76-136. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/bf01837709 OpenAlex: https://openalex.org/W1965210252
    Crossref OpenAlex
  16. R. Nathan Spreng , Raymond A. Mar , Alice S. N. Kim (2009). The Common Neural Basis of Autobiographical Memory, Prospection, Navigation, Theory of Mind, and the Default Mode: A Quantitative Meta-analysis . Journal of Cognitive Neuroscience, 21(3), 489-510. MIT Press.
    Type: Article DOI: 10.1162/jocn.2008.21029 OpenAlex: https://openalex.org/W2144421443
    Crossref OpenAlex OpenCitations
  17. Ling-Li Zeng , Danhong Wang , Michael D. Fox , Mert Sabuncu , Dewen Hu , Manling Ge et al. (2014). Neurobiological basis of head motion in brain imaging . Proceedings of the National Academy of Sciences, 111(16), 6058-6062. National Academy of Sciences.
    Type: Article DOI: 10.1073/pnas.1317424111 OpenAlex: https://openalex.org/W1966421226
    Crossref OpenAlex OpenCitations
  18. Simon Baron-Cohen (2009). Autism: The Empathizing–Systemizing (E‐S) Theory . Annals of the New York Academy of Sciences, 1156(1), 68-80. Wiley.
    Type: Article DOI: 10.1111/j.1749-6632.2009.04467.x OpenAlex: https://openalex.org/W2028758511
    Crossref OpenAlex OpenCitations
  19. Melissa Kirkovski , Peter G. Enticott , Paul B. Fitzgerald (2013). A Review of the Role of Female Gender in Autism Spectrum Disorders . Journal of Autism and Developmental Disorders, 43(11), 2584-2603. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-013-1811-1 OpenAlex: https://openalex.org/W2053496010
    Crossref OpenAlex OpenCitations
  20. Shih-Jen Weng , Jillian Lee Wiggins , Scott J. Peltier , Melisa Carrasco , Susan Risi , Catherine Lord et al. (2010). Alterations of resting state functional connectivity in the default network in adolescents with autism spectrum disorders . Brain Research, 1313, 202-214. Elsevier BV.
    Type: Article DOI: 10.1016/j.brainres.2009.11.057 OpenAlex: https://openalex.org/W1969700144
    Crossref OpenAlex OpenCitations
  21. Simon Baron-Cohen (2002). The extreme male brain theory of autism . Trends in Cognitive Sciences, 6(6), 248-254. Elsevier BV.
    Type: Article DOI: 10.1016/s1364-6613(02)01904-6 OpenAlex: https://openalex.org/W2131018314
    Crossref OpenAlex OpenCitations
  22. Bharat B. Biswal , Maarten Mennes , Xi-Nian Zuo , Suril Gohel , Clare Kelly , Steve M. Smith et al. (2010). Toward discovery science of human brain function . Proceedings of the National Academy of Sciences, 107(10), 4734-4739. National Academy of Sciences.
    Type: Article DOI: 10.1073/pnas.0911855107 OpenAlex: https://openalex.org/W2008607322
    Crossref OpenAlex OpenCitations
  23. Colm G. Connolly , Jing Wu , Tiffany C. Ho , Fumiko Hoeft , Owen Wolkowitz , Stuart Eisendrath et al. (2013). Resting-State Functional Connectivity of Subgenual Anterior Cingulate Cortex in Depressed Adolescents . Biological Psychiatry, 74(12), 898-907. Elsevier BV.
    Type: Article DOI: 10.1016/j.biopsych.2013.05.036 OpenAlex: https://openalex.org/W1970006078
    Crossref OpenAlex OpenCitations
  24. iPSYCH-SSI-Broad Autism Group , Elise Robinson , Beaté St Pourcain , Verneri Anttila , Jack A Kosmicki , Brendan Bulik-Sullivan et al. (2016). Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population . Nature Genetics, 48(5), 552-555. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/ng.3529 OpenAlex: https://openalex.org/W2303475965
    Crossref OpenAlex OpenCitations
  25. Michael D. Greicius , Benjamin H. Flores , Vinod Menon , Gary H. Glover , Hugh B. Solvason , Heather Kenna et al. (2007). Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus . Biological Psychiatry, 62(5), 429-437. Elsevier BV.
    Type: Article DOI: 10.1016/j.biopsych.2006.09.020 OpenAlex: https://openalex.org/W2095438393
    Crossref OpenAlex OpenCitations
  26. Michael D. Fox , Marcus E. Raichle (2007). Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging . Nature Reviews Neuroscience, 8(9), 700-711. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/nrn2201 OpenAlex: https://openalex.org/W1970695058
    Crossref OpenAlex OpenCitations
  27. Bonnie Auyeung , Kevin Taylor , Gerald Hackett , Simon Baron-Cohen (2010). Foetal testosterone and autistic traits in 18 to 24-month-old children . Molecular Autism, 1(1), 11. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/2040-2392-1-11 OpenAlex: https://openalex.org/W2148000302
    Crossref OpenAlex OpenCitations
  28. Ellen Leibenluft , Daniel S. Pine (2013). Resting State Functional Connectivity and Depression: In Search of a Bottom Line . Biological Psychiatry, 74(12), 868-869. Elsevier BV.
    Type: Article DOI: 10.1016/j.biopsych.2013.10.001 OpenAlex: https://openalex.org/W2009957469
    OpenCitations
  29. Lucina Q. Uddin , Kaustubh Supekar , Charles J. Lynch , Amirah Khouzam , Jennifer Phillips , Carl Feinstein et al. (2013). Salience Network–Based Classification and Prediction of Symptom Severity in Children With Autism . JAMA Psychiatry, 70(8), 869. American Medical Association (AMA).
    Type: Article DOI: 10.1001/jamapsychiatry.2013.104 OpenAlex: https://openalex.org/W1973140577
    Crossref OpenAlex OpenCitations
  30. Simon Baron-Cohen , B Auyeung , B Nørgaard-Pedersen , D M Hougaard , M W Abdallah , L Melgaard et al. (2015). Elevated fetal steroidogenic activity in autism . Molecular Psychiatry, 20(3), 369-376. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/mp.2014.48 OpenAlex: https://openalex.org/W2033077710
    Crossref OpenAlex OpenCitations
  31. Elena A. Allen , Erik B. Erhardt , Eswar Damaraju , William Gruner , Judith M. Segall , Rogers F. Silva et al. (2011). A Baseline for the Multivariate Comparison of Resting-State Networks . Frontiers in Systems Neuroscience, 5, 2. Frontiers Media SA.
    Type: Article DOI: 10.3389/fnsys.2011.00002 OpenAlex: https://openalex.org/W1973741448
    Crossref OpenAlex OpenCitations
  32. Daniel H Geschwind , Pat Levitt (2007). Autism spectrum disorders: developmental disconnection syndromes . Current Opinion in Neurobiology, 17(1), 103-111. Elsevier BV.
    Type: Article DOI: 10.1016/j.conb.2007.01.009 OpenAlex: https://openalex.org/W2002012536
    Crossref OpenAlex OpenCitations
  33. Leo Schilbach , Simon B. Eickhoff , Anna Rotarska-Jagiela , Gereon R. Fink , Kai Vogeley (2008). Minds at rest? Social cognition as the default mode of cognizing and its putative relationship to the “default system” of the brain . Consciousness and Cognition, 17(2), 457-467. Elsevier BV.
    Type: Article DOI: 10.1016/j.concog.2008.03.013 OpenAlex: https://openalex.org/W2128906604
    Crossref OpenAlex OpenCitations
  34. Jonathan D. Power , Anish Mitra , Timothy O. Laumann , Abraham Z. Snyder , Bradley L. Schlaggar , Steven E. Petersen (2014). Methods to detect, characterize, and remove motion artifact in resting state fMRI . NeuroImage, 84, 320-341. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2013.08.048 OpenAlex: https://openalex.org/W1973776237
    Crossref OpenAlex OpenCitations
  35. John N. Constantino , Tony Charman (2012). Gender Bias, Female Resilience, and the Sex Ratio in Autism . Journal of the American Academy of Child & Adolescent Psychiatry, 51(8), 756-758. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaac.2012.05.017 OpenAlex: https://openalex.org/W2014223535
    OpenCitations
  36. AnthonyG. Greenwald , Richard Gonzalez , Richard.J. Harris , Donald Guthrie (1996). Effect sizes and p values: What should be reported and what should be replicated? Psychophysiology, 33(2), 175-183. Wiley.
    Type: Article DOI: 10.1111/j.1469-8986.1996.tb02121.x OpenAlex: https://openalex.org/W1974251372
    Crossref OpenAlex OpenCitations
  37. Michael Lombardo , B. Chakrabarti , Edward T. Bullmore , S. A. Sadek , G. Pasco , S. J. Wheelwright et al. (2010). Atypical neural self-representation in autism . Brain, 133(2), 611-624. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/brain/awp306 OpenAlex: https://openalex.org/W2158715728
    Crossref OpenAlex OpenCitations
  38. Elisabeth A. H. von dem Hagen , Raliza S. Stoyanova , Simon Baron-Cohen , Andrew J. Calder (2013). Reduced functional connectivity within and between ‘social’ resting state networks in autism spectrum conditions . Social Cognitive and Affective Neuroscience, 8(6), 694-701. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/scan/nss053 OpenAlex: https://openalex.org/W2115943764
    Crossref OpenAlex OpenCitations
  39. Mikail Rubinov , Edward T. Bullmore (2013). Fledgling pathoconnectomics of psychiatric disorders . Trends in Cognitive Sciences, 17(12), 641-647. Elsevier BV.
    Type: Article DOI: 10.1016/j.tics.2013.10.007 OpenAlex: https://openalex.org/W1975101734
    Crossref OpenAlex OpenCitations
  40. Jessica R. Andrews-Hanna , Jay S. Reidler , Jorge Sepulcre , Renee Poulin , Randy L. Buckner (2010). Functional-Anatomic Fractionation of the Brain's Default Network . Neuron, 65(4), 550-562. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuron.2010.02.005 OpenAlex: https://openalex.org/W1991771535
    Crossref OpenAlex OpenCitations
  41. Vladimir L. Cherkassky , Rajesh K. Kana , Timothy A. Keller , Marcel Adam Just (2006). Functional connectivity in a baseline resting-state network in autism . NeuroReport, 17(16), 1687-1690. Ovid Technologies (Wolters Kluwer Health).
    Type: Article DOI: 10.1097/01.wnr.0000239956.45448.4c OpenAlex: https://openalex.org/W2146511652
    Crossref OpenAlex OpenCitations
  42. Rogier B. Mars , Franz-Xaver Neubert , MaryAnn P. Noonan , Jerome Sallet , Ivan Toni , Matthew F. S. Rushworth (2012). On the relationship between the “default mode network” and the “social brain” . Frontiers in Human Neuroscience, 6, 189-189. Frontiers Media SA.
    Type: Article DOI: 10.3389/fnhum.2012.00189 OpenAlex: https://openalex.org/W2007239727
    Crossref OpenAlex OpenCitations
  43. Elise Robinson , Paul Lichtenstein , Henrik Anckarsäter , Francesca Happé , Angelica Ronald (2013). Examining and interpreting the female protective effect against autistic behavior . Proceedings of the National Academy of Sciences, 110(13), 5258-5262. National Academy of Sciences.
    Type: Article DOI: 10.1073/pnas.1211070110 OpenAlex: https://openalex.org/W2129873641
    Crossref OpenAlex OpenCitations
  44. Elizabeth Redcay , Joseph M. Moran , Penelope L. Mavros , Helen Tager-Flusberg , John D. E. Gabrieli , Susan Whitfield-Gabrieli (2013). Intrinsic functional network organization in high-functioning adolescents with autism spectrum disorder . Frontiers in Human Neuroscience, 7, 573. Frontiers Media SA.
    Type: Article DOI: 10.3389/fnhum.2013.00573 OpenAlex: https://openalex.org/W2012274058
    Crossref OpenAlex OpenCitations
  45. Daniel P. Kennedy , Elizabeth Redcay , Eric Courchesne (2006). Failing to deactivate: Resting functional abnormalities in autism . Proceedings of the National Academy of Sciences, 103(21), 8275-8280. National Academy of Sciences.
    Type: Article DOI: 10.1073/pnas.0600674103 OpenAlex: https://openalex.org/W2043038397
    Crossref OpenAlex OpenCitations
  46. David C. Glahn , Emma E.M. Knowles , D. Reese McKay , Emma Sprooten , Henriette Raventós , John Blangero et al. (2014). Arguments for the sake of endophenotypes: Examining common misconceptions about the use of endophenotypes in psychiatric genetics . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 165(2), 122-130. Wiley.
    Type: Article DOI: 10.1002/ajmg.b.32221 OpenAlex: https://openalex.org/W2002409209
    Crossref OpenAlex OpenCitations
  47. Marco Iacoboni (2006). Failure to deactivate in autism: the co-constitution of self and other . Trends in Cognitive Sciences, 10(10), 431-433. Elsevier BV.
    Type: Article DOI: 10.1016/j.tics.2006.08.002 OpenAlex: https://openalex.org/W2021334340
    Crossref OpenAlex OpenCitations
  48. Catherine A. Burrows , Angela R. Laird , Lucina Q. Uddin (2016). Functional connectivity of brain regions for self‐ and other‐evaluation in children, adolescents and adults with autism . Developmental Science, 19(4), 564-580. Wiley.
    Type: Article DOI: 10.1111/desc.12400 OpenAlex: https://openalex.org/W2235723937
    Crossref OpenAlex OpenCitations
  49. Michael D. Spencer , Lindsay R. Chura , Rosemary Holt , John Suckling , Andrew J Calder , Edward T. Bullmore et al. (2012). Failure to deactivate the default mode network indicates a possible endophenotype of autism . Molecular Autism, 3(1), 15. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/2040-2392-3-15 OpenAlex: https://openalex.org/W2166225090
    Crossref OpenAlex OpenCitations
  50. Theodore D. Satterthwaite , Mark A. Elliott , Raphael T. Gerraty , Kosha Ruparel , James Loughead , Monica E. Calkins et al. (2013). An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data . NeuroImage, 64, 240-256. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2012.08.052 OpenAlex: https://openalex.org/W2007318901
    Crossref OpenAlex OpenCitations
  51. Michal Assaf , Kanchana Jagannathan , Vince D. Calhoun , Laura Miller , Michael C. Stevens , Robert Sahl et al. (2010). Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients . NeuroImage, 53(1), 247-256. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2010.05.067 OpenAlex: https://openalex.org/W2063167566
    Crossref OpenAlex OpenCitations
  52. Jonathan D. Power , Alexander L. Cohen , Steven M. Nelson , Gagan S. Wig , Kelly Anne Barnes , Jessica A. Church et al. (2011). Functional Network Organization of the Human Brain . Neuron, 72(4), 665-678. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuron.2011.09.006 OpenAlex: https://openalex.org/W2089572795
    Crossref OpenAlex OpenCitations
  53. Charles J. Lynch , Lucina Q. Uddin , Kaustubh Supekar , Amirah Khouzam , Jennifer Phillips , Vinod Menon (2013). Default Mode Network in Childhood Autism: Posteromedial Cortex Heterogeneity and Relationship with Social Deficits . Biological Psychiatry, 74(3), 212-219. Elsevier BV.
    Type: Article DOI: 10.1016/j.biopsych.2012.12.013 OpenAlex: https://openalex.org/W2079554826
    Crossref OpenAlex OpenCitations
  54. Stephen J. Gotts , Ziad S. Saad , Hang Joon Jo , Gregory L. Wallace , Robert W. Cox , Alex Martin (2013). The perils of global signal regression for group comparisons: a case study of Autism Spectrum Disorders . Frontiers in Human Neuroscience, 7, 356. Frontiers Media SA.
    Type: Article DOI: 10.3389/fnhum.2013.00356 OpenAlex: https://openalex.org/W2044820817
    Crossref OpenAlex OpenCitations
  55. Katharina Dworzynski , Angelica Ronald , Patrick Bolton , Francesca Happé (2012). How Different Are Girls and Boys Above and Below the Diagnostic Threshold for Autism Spectrum Disorders? Journal of the American Academy of Child & Adolescent Psychiatry, 51(8), 788-797. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaac.2012.05.018 OpenAlex: https://openalex.org/W2019357894
    Crossref OpenAlex OpenCitations
  56. Meng-Chuan Lai , Michael Lombardo , John Suckling , Amber Ruigrok , B. Chakrabarti , Christine Ecker et al. (2013). Biological sex affects the neurobiology of autism . Brain, 136(9), 2799-2815. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/brain/awt216 OpenAlex: https://openalex.org/W2160449790
    Crossref OpenAlex OpenCitations
  57. Christopher S. Monk , Scott J. Peltier , Jillian Lee Wiggins , Shih-Jen Weng , Melisa Carrasco , Susan Risi et al. (2009). Abnormalities of intrinsic functional connectivity in autism spectrum disorders, . NeuroImage, 47(2), 764-772. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2009.04.069 OpenAlex: https://openalex.org/W2158200838
    Crossref OpenAlex OpenCitations
  58. Dorothea L. Floris , Lindsay R. Chura , Rosemary Holt , John Suckling , Edward T. Bullmore , Simon Baron-Cohen et al. (2013). Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited . Journal of Autism and Developmental Disorders, 43(8), 1758-1772. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-012-1720-8 OpenAlex: https://openalex.org/W2027260549
    Crossref OpenAlex OpenCitations
  59. Daniel P. Kennedy , Eric Courchesne (2008). The intrinsic functional organization of the brain is altered in autism . NeuroImage, 39(4), 1877-1885. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2007.10.052 OpenAlex: https://openalex.org/W2055866745
    Crossref OpenAlex OpenCitations
  60. Theodore D. Satterthwaite , Daniel H. Wolf , James Loughead , Kosha Ruparel , Mark A. Elliott , Hakon Hakonarson et al. (2012). Impact of in-scanner head motion on multiple measures of functional connectivity: Relevance for studies of neurodevelopment in youth . NeuroImage, 60(1), 623-632. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2011.12.063 OpenAlex: https://openalex.org/W2048857243
    Crossref OpenAlex OpenCitations
  61. A Di Martino , C-G Yan , Q Li , E Denio , F X Castellanos , K Alaerts et al. (2014). The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism . Molecular Psychiatry, 19(6), 659-667. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/mp.2013.78 OpenAlex: https://openalex.org/W2167868121
    Crossref OpenAlex OpenCitations
  62. Jonathan D. Power , Bradley L. Schlaggar , Steven E. Petersen (2015). Recent progress and outstanding issues in motion correction in resting state fMRI . NeuroImage, 105, 536-551. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2014.10.044 OpenAlex: https://openalex.org/W2033865693
    Crossref OpenAlex OpenCitations
  63. Michael D. Spencer , Rosemary Holt , Lindsay R. Chura , John Suckling , A J Calder , Edward T. Bullmore et al. (2011). A novel functional brain imaging endophenotype of autism: the neural response to facial expression of emotion . Translational Psychiatry, 1(7), e19-e19. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/tp.2011.18 OpenAlex: https://openalex.org/W2070868801
    Crossref OpenAlex OpenCitations
  64. Rosemary Holt , Lindsay R. Chura , Meng-Chuan Lai , John Suckling , E. von dem Hagen , A. J. Calder et al. (2014). ‘Reading the Mind in the Eyes’: an fMRI study of adolescents with autism and their siblings . Psychological Medicine, 44(15), 3215-3227. Cambridge University Press (CUP).
    Type: Article DOI: 10.1017/s0033291714000233 OpenAlex: https://openalex.org/W2168743071
    Crossref OpenAlex OpenCitations
  65. Jason S. Nomi , Lucina Q. Uddin (2015). Developmental changes in large-scale network connectivity in autism . NeuroImage: Clinical, 7, 732-741. Elsevier BV.
    Type: Article DOI: 10.1016/j.nicl.2015.02.024 OpenAlex: https://openalex.org/W2043875710
    Crossref OpenAlex OpenCitations
  66. Robert W. Cox (1996). AFNI: Software for Analysis and Visualization of Functional Magnetic Resonance Neuroimages . Computers and Biomedical Research, 29(3), 162-173. Elsevier BV.
    Type: Article DOI: 10.1006/cbmr.1996.0014 OpenAlex: https://openalex.org/W2117140276
    Crossref OpenAlex OpenCitations
  67. Michael D. Spencer , Rosemary Holt , Lindsay R. Chura , Andrew J. Calder , John Suckling , Edward T. Bullmore et al. (2012). Atypical activation during the Embedded Figures Task as a functional magnetic resonance imaging endophenotype of autism . Brain, 135(11), 3469-3480. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/brain/aws229 OpenAlex: https://openalex.org/W2133048684
    Crossref OpenAlex OpenCitations
  68. Thomas Frazier , Stelios Georgiades , Somer Bishop , Antonio Y. Hardan (2014). Behavioral and Cognitive Characteristics of Females and Males With Autism in the Simons Simplex Collection . Journal of the American Academy of Child & Adolescent Psychiatry, 53(3), 329-340.e3. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaac.2013.12.004 OpenAlex: https://openalex.org/W2049713670
    Crossref OpenAlex OpenCitations
  69. D M Lisiecka , Rosemary Holt , R Tait , M Ford , Meng-Chuan Lai , Lindsay R. Chura et al. (2015). Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence . Translational Psychiatry, 5(3), e529-e529. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/tp.2015.23 OpenAlex: https://openalex.org/W2131139297
    Crossref OpenAlex OpenCitations
  70. Catherine Lord , Susan Risi , Linda Lambrecht , Edwin H. Cook , Bennett L. Leventhal , Pamela C. DiLavore et al. (2000). The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of Autism . Journal of Autism and Developmental Disorders, 30(3), 205-223. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1023/a:1005592401947 OpenAlex: https://openalex.org/W2144446993
    Crossref OpenAlex OpenCitations
  71. Kaat Alaerts , Stephan P. Swinnen , Nicole Wenderoth (2016). Sex differences in autism: a resting-state fMRI investigation of functional brain connectivity in males and females . Social Cognitive and Affective Neuroscience, 11(6), 1002-1016. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/scan/nsw027 OpenAlex: https://openalex.org/W2304458595
    Crossref OpenAlex OpenCitations
  72. Le Couteur (2003). The autism diagnostic interview-revised (ADI-R) .
    Type: Autre
    Crossref
  73. Tessa Taylor Rivet , Johnny L. Matson (2011). Review of gender differences in core symptomatology in autism spectrum disorders . Research in Autism Spectrum Disorders, 5(3), 957-976. Elsevier BV.
    Type: Article DOI: 10.1016/j.rasd.2010.12.003 OpenAlex: https://openalex.org/W2068847942
    Crossref OpenAlex OpenCitations
  74. Koene R.A. Van Dijk , Mert R. Sabuncu , Randy L. Buckner (2012). The influence of head motion on intrinsic functional connectivity MRI . NeuroImage, 59(1), 431-438. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2011.07.044 OpenAlex: https://openalex.org/W2132175842
    Crossref OpenAlex OpenCitations
  75. (2000). Diagnostic and Statistical Manual of Mental Disorders .
    Type: Autre
    Crossref
  76. Cindy C Hagan , Julia ME Graham , Barry Widmer , Rosemary Holt , Cinly Ooi , Adrienne O van Nieuwenhuizen et al. (2013). Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: study protocol for Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies (MR-IMPACT) . BMC Psychiatry, 13(1), 247. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/1471-244x-13-247 OpenAlex: https://openalex.org/W2095404614
    Crossref OpenAlex OpenCitations
  77. Lewis G Halsey , Douglas Curran-Everett , Sarah L Vowler , Gordon B Drummond (2015). The fickle P value generates irreproducible results . Nature Methods, 12(3), 179-185. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/nmeth.3288 OpenAlex: https://openalex.org/W2075418882
    Crossref OpenAlex OpenCitations
  78. Rachel M. Hiller , Robyn L. Young , Nathan Weber (2014). Sex Differences in Autism Spectrum Disorder based on DSM-5 Criteria: Evidence from Clinician and Teacher Reporting . Journal of Abnormal Child Psychology, 42(8), 1381-1393. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10802-014-9881-x OpenAlex: https://openalex.org/W2077948545
    Crossref OpenAlex OpenCitations
  79. Mark Jenkinson , Christian F. Beckmann , Timothy E.J. Behrens , Mark W. Woolrich , Stephen M. Smith (2012). FSL . NeuroImage, 62(2), 782-790. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuroimage.2011.09.015 OpenAlex: https://openalex.org/W2977883299
    Crossref OpenAlex OpenCitations
  80. Simon Baron-Cohen (2005). Testing the extreme male brain (EMB) theory of autism: Let the data speak for themselves . Cognitive Neuropsychiatry, 10(1), 77-81. Informa UK Limited.
    Type: Article DOI: 10.1080/13546800344000336 OpenAlex: https://openalex.org/W2078925478
    Crossref OpenAlex OpenCitations
  81. Bruce Thompson (2007). Effect sizes, confidence intervals, and confidence intervals for effect sizes . Psychology in the Schools, 44(5), 423-432. Wiley.
    Type: Article DOI: 10.1002/pits.20234 OpenAlex: https://openalex.org/W2081574221
    Crossref OpenAlex OpenCitations
  82. Susan Whitfield-Gabrieli , Judith M. Ford (2012). Default Mode Network Activity and Connectivity in Psychopathology . Annual Review of Clinical Psychology, 8(1), 49-76. Annual Reviews.
    Type: Article DOI: 10.1146/annurev-clinpsy-032511-143049 OpenAlex: https://openalex.org/W2104016179
    Crossref OpenAlex OpenCitations
  83. S Kapur , A G Phillips , T R Insel (2012). Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Molecular Psychiatry, 17(12), 1174-1179. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1038/mp.2012.105 OpenAlex: https://openalex.org/W2168463527
    Crossref OpenAlex OpenCitations
  84. Arthur P. Arnold (2009). The organizational–activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues . Hormones and Behavior, 55(5), 570-578. Elsevier BV.
    Type: Article DOI: 10.1016/j.yhbeh.2009.03.011 OpenAlex: https://openalex.org/W2101292935
    Crossref OpenAlex OpenCitations
  85. Joseph D Buxbaum , Catalina Betancur , Ozlem Bozdagi , Nate P Dorr , Gregory A Elder , Patrick R Hof (2012). Optimizing the phenotyping of rodent ASD models: enrichment analysis of mouse and human neurobiological phenotypes associated with high-risk autism genes identifies morphological, electrophysiological, neurological, and behavioral features . Molecular Autism, 3(1), 1. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/2040-2392-3-1 OpenAlex: https://openalex.org/W2111391133
    OpenAlex OpenCitations
  86. Huber (1981). Robust statistics .
    Type: Autre
    Crossref
  87. Simon Baron-Cohen , Sally Wheelwright , Jacqueline Hill , Yogini Raste , Ian Plumb (2001). The “Reading the Mind in the Eyes” Test Revised Version: A Study with Normal Adults, and Adults with Asperger Syndrome or High‐functioning Autism . Journal of Child Psychology and Psychiatry, 42(2), 241-251. Wiley.
    Type: Article DOI: 10.1111/1469-7610.00715 OpenAlex: https://openalex.org/W4294333904
    Crossref OpenAlex OpenCitations
  88. Simon Baron-Cohen , S Wheelwright , J Hill , Y Raste , I Plumb (2001). The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. PubMed, 42(2), 241-51.
    Type: Article OpenAlex: https://openalex.org/W2134822928
    OpenAlex
  89. Thomas Frazier , Stelios Georgiades , Somer Bishop , Antonio Y. Hardan (2014). Dr. Frazier et al. reply: . Journal of the American Academy of Child & Adolescent Psychiatry, 53(6), 700-701. Elsevier BV.
    Type: Article DOI: 10.1016/j.jaac.2014.04.002 OpenAlex: https://openalex.org/W1986179518
    OpenCitations
  90. Heather Cody Hazlett , Michele D. Poe , Guido Gerig , Martin Styner , Chad Chappell , Rachel Gimpel Smith et al. (2011). Early Brain Overgrowth in Autism Associated With an Increase in Cortical Surface Area Before Age 2 Years . Archives of General Psychiatry, 68(5), 467. American Medical Association (AMA).
    Type: Article DOI: 10.1001/archgenpsychiatry.2011.39 OpenAlex: https://openalex.org/W2155347288
    Crossref OpenAlex OpenCitations
  91. Janet B W Williams , Michael First (2013). Diagnostic and Statistical Manual of Mental Disorders . Encyclopedia of Social Work. Oxford University PressNew York, NY.
    Type: Autre DOI: 10.1093/acrefore/9780199975839.013.104 OpenAlex: https://openalex.org/W2159011576
    OpenAlex
  92. Arnold A. Gerall (2009). Recollections of the origins of and reactions to the organizational concept . Hormones and Behavior, 55(5), 567-569. Elsevier BV.
    Type: Article DOI: 10.1016/j.yhbeh.2009.03.001 OpenAlex: https://openalex.org/W2092342527
    OpenCitations
  93. Simon Baron-Cohen (1999). The Extreme Male-Brain Theory of Autism . Dans Neurodevelopmental Disorders (pp. 390-418). The MIT Press.
    Type: Chapitre de livre DOI: 10.7551/mitpress/4945.003.0023 OpenAlex: https://openalex.org/W2969951321
    OpenAlex