Essai clinique
Récupéré
Publication
clinicaltrials.gov
Centre for Addiction and Mental Health
(2024).
Psilocybin for Treatment-Resistant Depression in Autism.
ClinicalTrials.gov.
Centre for Addiction and Mental Health.
- Date de publication
-
01/11/2024
- Identifiant
-
NCT06731621
- Auteurs
-
Centre for Addiction and Mental Health
- Source
- ClinicalTrials.gov
- Type de référence
- clinical_trial
- Éditeur
- Centre for Addiction and Mental Health
- Source de métadonnées
- clinicaltrials.gov
Résumé
We propose a first-of-its-kind open-label clinical trial to investigate the feasibility, tolerability, and safety of administering psilocybin in autistic adults with treatment-resistant depression (TRD). In this study, 20 participants (intellectually able and fluent-speech adults) with autism and co-occurring TRD will receive around 20 hours of manualized psychotherapy that has previously been used with psilocybin (Agin-Liebes et al., 2020). They will also receive psilocybin at 2 different time points, firstly a safety dose of 10mg, followed by a treatment dose of 25mg. This study design is in accordance with previous studies investigating the use of psilocybin with psilocybin-assisted therapy (PAT) to treat TRD (Carhart-Harris et al., 2016, 2018)