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Post published on Bluesky on 18 Dec 2024 10:53

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Bluesky Clinical trial clinicaltrials.gov Extract quoted in the post Question asked by Dawson in the post External link integrated into the post Autism terms
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Registered: "a first-of-its-kind open-label clinical trial to investigate the feasibility, tolerability, and safety of administering psilocybin in autistic adults with treatment-resistant depression"? clinicaltrials.gov/study/NCT067... planned N=20 (age 18-65 years), in Toronto

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Clinical trial

Centre for Addiction and Mental Health (2024). Psilocybin for Treatment-Resistant Depression in Autism. ClinicalTrials.gov. Centre for Addiction and Mental Health.

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Clinical trial Fetched Post clinicaltrials.gov

Centre for Addiction and Mental Health (2024). Psilocybin for Treatment-Resistant Depression in Autism. ClinicalTrials.gov. Centre for Addiction and Mental Health.

Publication date
1 Nov 2024
Identifier
NCT06731621
Authors
Centre for Addiction and Mental Health
Source
ClinicalTrials.gov
Reference type
clinical_trial
Publisher
Centre for Addiction and Mental Health
Metadata source
clinicaltrials.gov

Abstract

We propose a first-of-its-kind open-label clinical trial to investigate the feasibility, tolerability, and safety of administering psilocybin in autistic adults with treatment-resistant depression (TRD). In this study, 20 participants (intellectually able and fluent-speech adults) with autism and co-occurring TRD will receive around 20 hours of manualized psychotherapy that has previously been used with psilocybin (Agin-Liebes et al., 2020). They will also receive psilocybin at 2 different time points, firstly a safety dose of 10mg, followed by a treatment dose of 25mg. This study design is in accordance with previous studies investigating the use of psilocybin with psilocybin-assisted therapy (PAT) to treat TRD (Carhart-Harris et al., 2016, 2018)

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