DOI work
Fetched
Post
crossref
John P. A. Ioannidis, Tiago V. Pereira, Ralph I. Horwitz
(2013).
Emergence of Large Treatment Effects From Small Trials—Reply.
JAMA, 309(8), 768.
American Medical Association (AMA).
- Publication date
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27 Feb 2013
- Identifier
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10.1001/jama.2012.208831
- Authors
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John P. A. Ioannidis,
Tiago V. Pereira,
Ralph I. Horwitz
- Source
- JAMA
- Details
- 309(8), 768
- Reference type
- article
- Publisher
- American Medical Association (AMA)
- Metadata source
- crossref
Abstract
In Reply: We agree with Drs Batterham and Hopkins that small studies are not necessarily inherently flawed. However, probabilistically speaking, even in the absence of biases, small-sized trials are more prone to provide overestimates (or underestimates) compared with larger trials.
Study authors in this cited reference