Michelle Dawson posts

Post published on Twitter/X on 1 Mar 2013 10:41

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John P. A. Ioannidis, Tiago V. Pereira, Ralph I. Horwitz (2013). Emergence of Large Treatment Effects From Small Trials—Reply. JAMA, 309(8), 768. American Medical Association (AMA).

Publication date
27 Feb 2013
Identifier
10.1001/jama.2012.208831
Authors
John P. A. Ioannidis, Tiago V. Pereira, Ralph I. Horwitz
Source
JAMA
Details
309(8), 768
Reference type
article
Publisher
American Medical Association (AMA)
Metadata source
crossref

Abstract

In Reply: We agree with Drs Batterham and Hopkins that small studies are not necessarily inherently flawed. However, probabilistically speaking, even in the absence of biases, small-sized trials are more prone to provide overestimates (or underestimates) compared with larger trials.

Study authors in this cited reference