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Volker Sturm, Oliver Fricke, Christian P. Bührle, Doris Lenartz, Mohammad Maarouf, Harald Treuer, Jürgen K. Mai, Gerd Lehmkuhl
(2013).
DBS in the basolateral amygdala improves symptoms of autism and related self-injurious behavior: a case report and hypothesis on the pathogenesis of the disorder.
Frontiers in Human Neuroscience, 6, 341-341.
Frontiers Media SA.
- Publication date
-
2013
- Identifier
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10.3389/fnhum.2012.00341
- Authors
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Volker Sturm,
Oliver Fricke,
Christian P. Bührle,
Doris Lenartz,
Mohammad Maarouf,
Harald Treuer,
Jürgen K. Mai,
Gerd Lehmkuhl
- Source
- Frontiers in Human Neuroscience
- Details
- 6, 341-341
- Reference type
- article
- Publisher
- Frontiers Media SA
- Metadata source
- crossref
Abstract
We treated a 13-year-old boy for life-threatening self-injurious behavior (SIB) and severe Kanner's autism with deep brain stimulation (DBS) in the amygdaloid complex as well as in the supra-amygdaloid projection system. Two DBS-electrodes were placed in both structures of each hemisphere. The stimulation contacts targeted the paralaminar, the basolateral (BL), the central amygdala as well as the supra-amygdaloid projection system. DBS was applied to each of these structures, but only stimulation of the BL part proved effective in improving SIB and core symptoms of the autism spectrum in the emotional, social, and even cognitive domains over a follow up of now 24 months. These results, which have been gained for the first time in a patient, support hypotheses, according to which the amygdala may be pivotal in the pathogeneses of autism and point to the special relevance of the BL part.
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