Michelle Dawson posts

Post published on Twitter/X on 26 Feb 2022 05:11

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Twitter/X DOI work crossref Extract quoted in the post Question asked by Dawson in the post External link integrated into the post Autism terms
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26 Feb 2022 05:17

Note, autism phenotype in this study, for repetitive behavior: "did not move their hind paws and displayed protracted bouts of either self-grooming, or exhibiting stereotypic circling, forward, backward or sideward movements, or were sitting and only moving their head"?

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DOI work

Sebastian Krüttner, Antonio Falasconi, Sergio Valbuena, Ivan Galimberti, Tewis Bouwmeester, Silvia Arber, Pico Caroni (2022). Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling. Neuron, 110(9), 1468-1482.e5. Elsevier BV.

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DOI work Fetched Post crossref

Sebastian Krüttner, Antonio Falasconi, Sergio Valbuena, Ivan Galimberti, Tewis Bouwmeester, Silvia Arber, Pico Caroni (2022). Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling. Neuron, 110(9), 1468-1482.e5. Elsevier BV.

Publication date
May 2022
Identifier
10.1016/j.neuron.2022.02.001
Authors
Sebastian Krüttner, Antonio Falasconi, Sergio Valbuena, Ivan Galimberti, Tewis Bouwmeester, Silvia Arber, Pico Caroni
Source
Neuron
Details
110(9), 1468-1482.e5
Reference type
article
Publisher
Elsevier BV
Metadata source
crossref

Abstract

mice by the chemogenetic activation of PreL→TS projection neurons. Environmental enrichment prevented ASD-like phenotypes by obviating the dependence on PreL→TS activity. Therefore, novel context experience has a key role in triggering ASD-like phenotypes in genetically predisposed mice, and behavioral therapies involving familiarity and enrichment might prevent the emergence of ASD phenotypes.

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