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Post published on Twitter/X on 8 Jul 2021 11:53

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Mei L. Law, Jatinder Singh, Mathilde Mastroianni, Paramala Santosh (2022). Parent-Mediated Interventions for Infants under 24 Months at Risk for Autism Spectrum Disorder: A Systematic Review of Randomized Controlled Trials. Journal of Autism and Developmental Disorders, 52(6), 2553-2574. Springer Science and Business Media LLC.

Publication date
8 Jul 2021
Identifier
10.1007/s10803-021-05148-9
Authors
Mei L. Law, Jatinder Singh, Mathilde Mastroianni, Paramala Santosh
Source
Journal of Autism and Developmental Disorders
Details
52(6), 2553-2574
Reference type
article
Publisher
Springer Science and Business Media LLC
Metadata source
crossref

Abstract

Abstract Prodromal symptoms of Autism Spectrum Disorder (ASD) have been detected within the first year of life. This review evaluated evidence from randomized controlled trials (RCTs) of parent-mediated interventions for infants under 24 months who are at risk for ASD. Electronic databases, including grey literature, were searched up till November 2019. Seven RCTs were identified. There was substantial heterogeneity in recruitment, outcome measures and effect size calculations. Interventions did not reduce the risk of later ASD diagnosis and post-intervention effects on infant outcomes were inconsistent, with five studies reporting significant improvements across both treatment and control groups. Moderate level of evidence of intervention effects on parental interaction skills and the small number of RCTs, and significant limitations restrict generalizability across studies.

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