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Post published on Twitter/X on 22 Jun 2020 15:17

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Eliza Kramer, Bonhwang Koo, Anita Restrepo, Maki Koyama, Rebecca Neuhaus, Kenneth Pugh, Charissa Andreotti, Michael Milham (2020). Diagnostic Associations of Processing Speed in a Transdiagnostic, Pediatric Sample. Scientific Reports, 10(1), 10114. Springer Science and Business Media LLC.

Publication date
22 Jun 2020
Identifier
10.1038/s41598-020-66892-z
Authors
Eliza Kramer, Bonhwang Koo, Anita Restrepo, Maki Koyama, Rebecca Neuhaus, Kenneth Pugh, Charissa Andreotti, Michael Milham
Source
Scientific Reports
Details
10(1), 10114
Reference type
article
Publisher
Springer Science and Business Media LLC
Metadata source
crossref

Abstract

Abstract Introduction: The present study examines the relationships between processing speed (PS), mental health disorders, and learning disorders. Prior work has tended to explore relationships between PS deficits and specific diagnoses in isolation of one another. Here, we simultaneously investigated PS associations with five diagnoses (i.e., anxiety, autism, ADHD, depressive, specific learning) in a large-scale, transdiagnostic, community self-referred sample. Method. 843 children, ages 8–16 were included from the Healthy Brain Network (HBN) Biobank. Principal component analysis (PCA) was employed to create a composite measure of four PS tasks, referred to as PC1. Intraclass correlation coefficient (ICC) between the four PS measures, as well as PC1, were calculated to assess reliability. Results. ICCs were moderate between WISC-V tasks (0.663), and relatively modest between NIH Toolbox Pattern Comparison and other PS scales (0.14–0.27). Regression analyses revealed specific significant relationships between PS and reading and math disabilities, ADHD-inattentive presentation (ADHD-I), and ADHD-combined presentation (ADHD-C). After accounting for inattention, the present study did not find a significant relationship with Autism Spectrum Disorder. Discussion. Our examination of PS in a large, transdiagnostic sample suggested more specific associations with ADHD and learning disorders than the literature currently suggests. Implications for understanding how PS interacts with a highly heterogeneous childhood sample are discussed.

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