Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation–Inhibition Balance in Autism Spectrum Disorder

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Hegarty, J. P., Weber, D. J., Cirstea, C. M., & Beversdorf, D. Q. (2018). Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation–Inhibition Balance in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 48(10), 3460-3473. https://doi.org/10.1007/s10803-018-3613-y

Publication date: 23 May 2018 Added to AutiHub: 5 Oct 2026 Type: Article Article language: English
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Authors

Publication authors
4
Publication authors identified as autistic
1 / 4 (25.0%)
  1. John P. Hegarty *
  2. Dylan J. Weber
  3. Carmen Mihaela Cirstea
  4. David Quentin Beversdorf

Abstract

Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD). The current investigation used resting state fMRI and proton magnetic resonance spectroscopy (1H-MRS) to examine the relationships between E/I (glutamate + glutamine/GABA) and FC of the dorsolateral prefrontal cortex and posterolateral cerebellar hemisphere from 14 adolescents/adults with ASD and 12 age/sex/IQ-matched controls. In this pilot sample, cerebro-cerebellar FC was positively associated with cerebellar E/I and listening comprehension abilities in individuals with ASD but not controls. Additionally, a subgroup of individuals with ASD and low FC (n = 5) exhibited reduced E/I and impaired listening comprehension. Thus, altered functional coherence of cerebro-cerebellar circuits in ASD may be related with a cerebellar E/I imbalance.

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Cited references
86
With a DOI
75
Without a DOI, from raw bibliography text
10
0 / 86 (0.0%) cited references include at least one author identified as autistic.
References with data to complete
4 / 86 (4.7%)
References with detected author names
85 / 86 (98.8%)
Without detected author names
1
Without a structured title
4
Without a stable identifier
9
References with raw author names still to review
1
References with external metadata lookup issues
1
These indicators apply to cited references displayed on this page, after technical duplicates have been merged. A reference without a DOI can still support author statistics when a title and author names are available.
Author names detected in the cited bibliography
419
From DOI or external metadata
419
From validated raw bibliography text
0
Raw names already validated
0
Raw names still to review
1
34 / 419 (8.1%) names are linked to an author already present in AutiHub. 385 / 419 (91.9%) names are not yet linked.
Names linked to a person identified as autistic
0 / 419 (0.0%)
Calculated across all author names detected in the cited bibliography. Among names linked to an author already present in AutiHub: 0 / 34 (0.0%). Distinct people identified as autistic: 0 / 388 (0.0%).
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