Elevated Thresholds for Light Touch in Children With Autism Reflect More Conservative Perceptual Decision-Making Rather Than a Sensory Deficit

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Quinde-Zlibut, J. M., Okitondo, C. D., Williams, Z. J., Weitlauf, A., Mash, L. E., Heflin, B. H., Woodward, N. D., & Cascio, C. J. (2020). Elevated Thresholds for Light Touch in Children With Autism Reflect More Conservative Perceptual Decision-Making Rather Than a Sensory Deficit. Frontiers in Human Neuroscience, 14, 122-122. https://doi.org/10.3389/fnhum.2020.00122

Publication date: 7 Apr 2020 Added to AutiHub: 7 Jul 2026 Type: Article Article language: English
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8
Publication authors identified as autistic
1 / 8 (12.5%)
  1. Jennifer M. Quinde-Zlibut
  2. Christian D. Okitondo
  3. Zachary J. Williams *
  4. Amy Weitlauf
  1. Lisa E. Mash
  2. Brynna H. Heflin
  3. Neil D. Woodward
  4. Carissa J. Cascio

Abstract

Individuals with autism spectrum disorder (ASD) are often behaviorally hyper-reactive to light touch, but it is unclear to what degree this arises from a fundamental sensory difference versus higher order systems for attention or emotion processing. Thus far, experimental findings for light touch detection are mixed, and few previous studies have independently considered sensitivity (the ability to discriminate signal from noise) and decision criterion (the overall response bias or tendency to answer ‘yes’ or ‘no’ in a detection task). We tested a large sample of children, adolescents, and adults with ASD (n=88) and with typical development (n=59) using von Frey filaments to derive light touch thresholds at the palm. We calculated signal detection metrics for sensitivity (Az) and response criterion (c) from hit and false alarm rates. Both metrics exhibited significant group differences, such that the ASD group was less sensitive, but had a much more conservative response criterion. We used a best subset model selection procedure in three separate ordinal regressions for the whole group, adults, and children adolescents. In all selected models, c was by far the most significant predictor of threshold, supplanting effects of diagnostic group that were significant in the baseline models. In contrast, Az was not a significant predictor of threshold in any of the models. Mean values of c were similar for adults with and without autism and for children/adolescents with ASD, but lower (more liberal) in children/adolescents with TD. This suggests that children with ASD exhibit a conservatism in their perceptual decision-making that differs from their TD peers but resembles that of adults. Across the sample, the value of c was significantly and positively correlated with age and with autism symptoms (SRS-2 total score), in addition to thresholds. The results of this study suggest that, rather than a sensory difference in detection of light touch, there is a difference in response bias such that children with ASD are more conservative/likely to report ‘no’ if unsure, than their young TD peers. Future work should consider the implications of conservative response criterion in ASD for commonly used forced-choice psychophysical paradigms.

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Cited references
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Total cited references integrated for this publication.
Cited references with an identified autistic author
2 / 53 (3.8%)
Cited author occurrences identified as autistic
2 / 170 (1.2%)
Among occurrences linked to AutiHub author records: 2 / 34 (5.9%). Distinct cited authors identified as autistic: 2 / 158 (1.3%).
Cited author occurrences linked to AutiHub author records
34 / 170 (20.0%)
Distinct linked cited authors: 27 / 158 (17.1%)
Linked cited-author occurrences not identified as autistic
32 / 34 (94.1%)
Among linked cited-author occurrences only. Across all cited-author occurrences: 32 / 170 (18.8%). Distinct linked cited authors not identified as autistic: 25 / 27 (92.6%).
  1. Du Feng , Norman Cliff (2004). Monte Carlo Evaluation of Ordinal d with Improved Confidence Interval . Journal of Modern Applied Statistical Methods, 3(2), 322-332. Scilight Press Pty Ltd.
    Type: Article DOI: 10.22237/jmasm/1099267560 OpenAlex: https://openalex.org/W78746584
    Crossref OpenAlex OpenCitations
  2. Thomas M. Achenbach (2015). Achenbach System of Empirically Based Assessment (ASEBA ) . The Encyclopedia of Clinical Psychology, 1-8. Wiley.
    Type: Other DOI: 10.1002/9781118625392.wbecp150 OpenAlex: https://openalex.org/W1520681366
    Crossref OpenAlex OpenCitations
  3. Eric-Jan Wagenmakers , Simon Farrell (2004). AIC model selection using Akaike weights . Psychonomic Bulletin & Review, 11(1), 192-196. Springer Science and Business Media LLC.
    Type: Article DOI: 10.3758/bf03206482 OpenAlex: https://openalex.org/W1987464952
    Crossref OpenAlex OpenCitations
  4. Phill Gagné , C. Mitchell Dayton (2002). Best Regression Model Using Information Criteria . Journal of Modern Applied Statistical Methods, 1(2), 479-488. Scilight Press Pty Ltd.
    Type: Article DOI: 10.22237/jmasm/1036110180 OpenAlex: https://openalex.org/W198250083
    Crossref OpenAlex OpenCitations
  5. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®) . Diagnostic and Statistical Manual Of Mental Disorders (DSM-5)..
    Type: Other
    Crossref
  6. Zheng Wang , Grant C. Magnon , Stormi P. White , Rachel K. Greene , David E. Vaillancourt , Matthew W. Mosconi (2015). Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping . Journal of Neurophysiology, 113(7), 1989-2001. American Physiological Society.
    Type: Article DOI: 10.1152/jn.00661.2014 OpenAlex: https://openalex.org/W2318624768
    Crossref OpenAlex OpenCitations
  7. Leanne Chukoskie , Jeanne Townsend , Marissa Westerfield (2013). Motor Skill in Autism Spectrum Disorders . International Review of Neurobiology, 113, 207-249. Elsevier.
    Type: Article DOI: 10.1016/b978-0-12-418700-9.00007-1 OpenAlex: https://openalex.org/W320098411
    Crossref OpenAlex OpenCitations
  8. Grace T. Baranek , Gershon Berkson (1994). Tactile defensiveness in children with developmental disabilities: Responsiveness and habituation . Journal of Autism and Developmental Disorders, 24(4), 457-471. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/bf02172128 OpenAlex: https://openalex.org/W2038594479
    Crossref OpenAlex OpenCitations
  9. Lauren K. Bryant , Tiffany G. Woynaroski , Mark T. Wallace , Carissa J. Cascio (2019). Self-reported Sensory Hypersensitivity Moderates Association Between Tactile Psychophysical Performance and Autism-Related Traits in Neurotypical Adults . Journal of Autism and Developmental Disorders, 49(8), 3159-3172. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-019-04043-8 OpenAlex: https://openalex.org/W2944153323
    Crossref OpenAlex OpenCitations
  10. Grace T. Baranek , Fabian J. David , Michele D. Poe , Wendy L. Stone , Linda R. Watson (2006). Sensory Experiences Questionnaire: discriminating sensory features in young children with autism, developmental delays, and typical development . Journal of Child Psychology and Psychiatry, 47(6), 591-601. Wiley.
    Type: Article DOI: 10.1111/j.1469-7610.2005.01546.x OpenAlex: https://openalex.org/W1980426547
    Crossref OpenAlex OpenCitations
  11. Catherine Lord , Michael Rutter , Ann Le Couteur (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders . Journal of Autism and Developmental Disorders, 24(5), 659-685. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/bf02172145 OpenAlex: https://openalex.org/W1980309199
    Crossref OpenAlex OpenCitations
  12. Guang Yong Zou (2007). Toward using confidence intervals to compare correlations. Psychological Methods, 12(4), 399-413. American Psychological Association (APA).
    Type: Article DOI: 10.1037/1082-989x.12.4.399 OpenAlex: https://openalex.org/W1966359789
    Crossref OpenAlex OpenCitations
  13. Danielle Z. Bolling , Naomi B. Pitskel , Ben Deen , Michael J. Crowley , James C. McPartland , Martha D. Kaiser et al. (2011). Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion . Developmental Cognitive Neuroscience, 1(3), 280-294. Elsevier BV.
    Type: Article DOI: 10.1016/j.dcn.2011.02.002 OpenAlex: https://openalex.org/W1995126515
    Crossref OpenAlex OpenCitations
  14. J. M. Thornbury , C. M. Mistretta (1981). Tactile Sensitivity as a Function of Age . Journal of Gerontology, 36(1), 34-39. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/geronj/36.1.34 OpenAlex: https://openalex.org/W1978761060
    Crossref OpenAlex OpenCitations
  15. Catana Brown , Nona Tollefson , Winnie Dunn , Rue Cromwell , Diane Filion (2001). The Adult Sensory Profile: Measuring Patterns of Sensory Processing . American Journal of Occupational Therapy, 55(1), 75-82. SAGE Publications.
    Type: Article DOI: 10.5014/ajot.55.1.75 OpenAlex: https://openalex.org/W2136918637
    Crossref OpenAlex OpenCitations
  16. Bernhard Treutwein (1995). Adaptive psychophysical procedures . Vision Research, 35(17), 2503-2522. Elsevier BV.
    Type: Article DOI: 10.1016/0042-6989(95)00016-x OpenAlex: https://openalex.org/W2040249719
    Crossref OpenAlex OpenCitations
  17. Norman Cliff (1993). Dominance statistics: Ordinal analyses to answer ordinal questions. Psychological Bulletin, 114(3), 494-509. American Psychological Association (APA).
    Type: Article DOI: 10.1037//0033-2909.114.3.494 OpenAlex: https://openalex.org/W4247834613
    Crossref OpenAlex OpenCitations
  18. Harold Stanislaw , Natasha Todorov (1999). Calculation of signal detection theory measures . Behavior Research Methods, Instruments, & Computers, 31(1), 137-149. Springer Science and Business Media LLC.
    Type: Article DOI: 10.3758/bf03207704 OpenAlex: https://openalex.org/W2057748516
    Crossref OpenAlex OpenCitations
  19. Carissa J. Cascio , Francis McGlone , Stephen Folger , Vinay Tannan , Grace T. Baranek , Kevin A. Pelphrey et al. (2008). Tactile Perception in Adults with Autism: a Multidimensional Psychophysical Study . Journal of Autism and Developmental Disorders, 38(1), 127-137. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-007-0370-8 OpenAlex: https://openalex.org/W2105884882
    Crossref OpenAlex OpenCitations
  21. Boin Choi , Kathryn A. Leech , Helen Tager-Flusberg , Charles A. Nelson (2018). Development of fine motor skills is associated with expressive language outcomes in infants at high and low risk for autism spectrum disorder . Journal of Neurodevelopmental Disorders, 10(1), 14-14. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/s11689-018-9231-3 OpenAlex: https://openalex.org/W2806968036
    Crossref OpenAlex OpenCitations
  22. Joseph C. Stevens , Marty Alvarez-Reeves , Loretta Dipietro , Gary W. Mack , Barry G. Green (2003). Decline of tactile acuity in aging: a study of body site, blood flow, and lifetime habits of smoking and physical activity . Somatosensory & Motor Research, 20(3-4), 271-279. Informa UK Limited.
    Type: Article DOI: 10.1080/08990220310001622997 OpenAlex: https://openalex.org/W2046458704
    Crossref OpenAlex OpenCitations
  23. Birk Diedenhofen , Jochen Musch (2015). cocor: A Comprehensive Solution for the Statistical Comparison of Correlations . PLOS ONE, 10(4), e0121945. Public Library of Science (PLoS).
    Type: Article DOI: 10.1371/journal.pone.0121945 OpenAlex: https://openalex.org/W1981244178
    Crossref OpenAlex OpenCitations
  24. Angelo Pirrone , Wen Wen , Sheng Li , Daniel H. Baker , Elizabeth Milne (2018). Autistic Traits in the Neurotypical Population do not Predict Increased Response Conservativeness in Perceptual Decision Making . Perception, 47(10-11), 1081-1096. SAGE Publications.
    Type: Article DOI: 10.1177/0301006618802689 OpenAlex: https://openalex.org/W2895760658
    Crossref OpenAlex OpenCitations
  25. Michelle O’Riordan , Filippo Passetti (2006). Discrimination in Autism Within Different Sensory Modalities . Journal of Autism and Developmental Disorders, 36(5), 665-675. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-006-0106-1 OpenAlex: https://openalex.org/W1988370154
    Crossref OpenAlex OpenCitations
  26. Constantino (2012). Social Responsiveness Scale (SRS) . Social Responsiveness Scale (SRS)..
    Type: Other
    Crossref
  27. Qi Liu , Bryan E. Shepherd , Chun Li , Frank E. Harrell (2017). Modeling continuous response variables using ordinal regression . Statistics in Medicine, 36(27), 4316-4335. Wiley.
    Type: Article DOI: 10.1002/sim.7433 OpenAlex: https://openalex.org/W2752223210
    Crossref OpenAlex OpenCitations
  28. Michael F. Verde , Neil A. Macmillan , Caren M. Rotello (2006). Measures of sensitivity based on a single hit rate and false alarm rate: The accuracy, precision, and robustness of′,A z, andA’ . Perception & Psychophysics, 68(4), 643-654. Springer Science and Business Media LLC.
    Type: Article DOI: 10.3758/bf03208765 OpenAlex: https://openalex.org/W2037161622
    Crossref OpenAlex OpenCitations
  29. Dunn (1999). B14 The Sensory Profile..
    Type: Other
    Crossref
  30. Megan MacDonald , Catherine Lord , Dale A. Ulrich (2014). Motor Skills and Calibrated Autism Severity in Young Children With Autism Spectrum Disorder . Adapted Physical Activity Quarterly, 31(2), 95-105. Human Kinetics.
    Type: Article DOI: 10.1123/apaq.2013-0068 OpenAlex: https://openalex.org/W2101593645
    Crossref OpenAlex OpenCitations
  31. Shafali S Jeste (2011). The neurology of autism spectrum disorders . Current Opinion in Neurology, 24(2), 132-139. Ovid Technologies (Wolters Kluwer Health).
    Type: Article DOI: 10.1097/wco.0b013e3283446450 OpenAlex: https://openalex.org/W2039976991
    Crossref OpenAlex OpenCitations
  32. Odette Fründt , Wiebke Grashorn , Daniel Schöttle , Ina Peiker , Nicole David , Andreas K. Engel et al. (2017). Quantitative Sensory Testing in adults with Autism Spectrum Disorders . Journal of Autism and Developmental Disorders, 47(4), 1183-1192. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-017-3041-4 OpenAlex: https://openalex.org/W2584125285
    Crossref OpenAlex OpenCitations
  33. Jana M. Iverson , Frederick Shic , Carla A. Wall , Katarzyna Chawarska , Suzanne Curtin , Annette Estes et al. (2019). Early motor abilities in infants at heightened versus low risk for ASD: A Baby Siblings Research Consortium (BSRC) study. Journal of Abnormal Psychology, 128(1), 69-80. American Psychological Association (APA).
    Type: Article DOI: 10.1037/abn0000390 OpenAlex: https://openalex.org/W2908892351
    Crossref OpenAlex OpenCitations
  34. N. J. D. NAGELKERKE (1991). A note on a general definition of the coefficient of determination . Biometrika, 78(3), 691-692. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/biomet/78.3.691 OpenAlex: https://openalex.org/W2123162799
    Crossref OpenAlex OpenCitations
  35. Francis McGlone , Johan Wessberg , Håkan Olausson (2014). Discriminative and Affective Touch: Sensing and Feeling . Neuron, 82(4), 737-755. Elsevier BV.
    Type: Article DOI: 10.1016/j.neuron.2014.05.001 OpenAlex: https://openalex.org/W2079458882
    Crossref OpenAlex OpenCitations
  36. Green (1966). B19 Signal Detection Theory And Psychophysics..
    Type: Other
    Crossref
  37. Frank E. Harrell, (2015). Regression Modeling Strategies . Springer International Publishing.
    Type: Book DOI: 10.1007/978-3-319-19425-7 OpenAlex: https://openalex.org/W2115709314
    Crossref OpenAlex OpenCitations
  38. Ginny Russell , Will Mandy , Daisy Elliott , Rhianna White , Tom Pittwood , Tamsin Ford (2019). Selection bias on intellectual ability in autism research: a cross-sectional review and meta-analysis . Molecular Autism, 10(1), 9. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1186/s13229-019-0260-x OpenAlex: https://openalex.org/W2927010782
    Crossref OpenAlex OpenCitations
  39. Brittany G. Travers , Erin D. Bigler , Tyler C. Duffield , Molly D.B. Prigge , Alyson L. Froehlich , Nicholas Lange et al. (2017). Longitudinal development of manual motor ability in autism spectrum disorder from childhood to mid‐adulthood relates to adaptive daily living skills . Developmental Science, 20(4). Wiley.
    Type: Article DOI: 10.1111/desc.12401 OpenAlex: https://openalex.org/W27061223
    Crossref OpenAlex OpenCitations
  40. D. R. Kenshalo (1986). Somesthetic Sensitivity in Young and Elderly Humans . Journal of Gerontology, 41(6), 732-742. Oxford University Press (OUP).
    Type: Article DOI: 10.1093/geronj/41.6.732 OpenAlex: https://openalex.org/W2166620045
    Crossref OpenAlex OpenCitations
  41. Sarah Vaughan , Francis McGlone , Helen Poole , David Moore (2020). A Quantitative Sensory Testing Approach to Pain in Autism Spectrum Disorders . Journal of Autism and Developmental Disorders, 50(5), 1607-1620. Springer Science and Business Media LLC.
    Type: Article DOI: 10.1007/s10803-019-03918-0 OpenAlex: https://openalex.org/W2913995063
    Crossref OpenAlex OpenCitations
  42. Lord (2012). Autism diagnostic observation schedule, second edition (ADOS-2) manual (part I): modules 1-4 . Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) Manual (Part I): Modules 1-4..
    Type: Other
    Crossref
  44. Inmaculada Riquelme , Samar M. Hatem , Pedro Montoya (2016). Abnormal Pressure Pain, Touch Sensitivity, Proprioception, and Manual Dexterity in Children with Autism Spectrum Disorders . Neural Plasticity, 2016, 1-9. Wiley.
    Type: Article DOI: 10.1155/2016/1723401 OpenAlex: https://openalex.org/W2183911126
    Crossref OpenAlex OpenCitations
  45. Beverly Vicker (2009). Social communication and language characteristics associated with high functioning, verbal children and adults with autism spectrum disorder . IUScholarWorks (Indiana University).
    Type: Article OpenAlex: https://openalex.org/W2197534413
    OpenAlex
  46. (2017). B32 R: A Language and Environment for Statistical Computing.
    Type: Other
    Crossref
  47. Rogmann (2013). Ordinal Dominance Statistics (orddom): an R Project for Statistical Computing Package To Compute Ordinal, Nonparametric Alternatives To Mean Comparison (Version 3.1) .
    Type: Other
    Crossref
  48. Rutter (2003). B36 The Social Communication Questionnaire..
    Type: Other
    Crossref
  49. Gideon Schwarz (1978). Estimating the Dimension of a Model . The Annals of Statistics, 6(2), 461. Institute of Mathematical Statistics.
    Type: Article DOI: 10.1214/aos/1176344136 OpenAlex: https://openalex.org/W2146855196
    Crossref OpenCitations
  50. J.D. Ingleby (1967). Signal detection theory and psychophysics . Journal of Sound and Vibration, 5(3), 519-521. Elsevier BV.
    Type: Article DOI: 10.1016/0022-460x(67)90197-6 OpenAlex: https://openalex.org/W2921629193
    OpenAlex
  51. Anne Snow (2013). Social Communication Questionnaire . In Encyclopedia of Autism Spectrum Disorders (pp. 2893-2895). Springer New York.
    Type: Book chapter DOI: 10.1007/978-1-4419-1698-3_1651 OpenAlex: https://openalex.org/W4250855288
    OpenAlex
  52. Vicker (2009). B45 Social Communication And Language Characteristics Associated With High Functioning, Verbal Children And Adults With Autism Spectrum Disorder..
    Type: Other
    Crossref
  53. Weschsler (1999). B48 Wechsler Abbreviated Scale of Intelligence (WASI)..
    Type: Other
    Crossref